Multiusuary equipament in the grant 2017/21629-5, flow cytometry FACS melody 2-lasers, 6-colors (4-2) blue violet

• Grant number: 19/11213-1
• Support Opportunities: Multi-user Equipment Program
• Start date: July 01, 2019
• End date: June 30, 2026
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Vânia Luiza Deperon Bonato
• Grantee: Vânia Luiza Deperon Bonato
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 17/21629-5 - Strategies to study pulmonary inflammation during comorbidities, AP.TEM
• EMU web page: Página do Equipamento Multiusuário não informada
• Type of equipment: Processos Biológicos - Caracterização - Contagem células (inclui citômetros)
• Manufacturer: Fabricante não informado
• Model: Modelo não informado

Abstract

Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this Proposal have a clear objective: to determine mechanisms that exacerbate pulmonary inflammation, aiming at the identification of molecules or cells that may represent the search for immunological targets for the development of innovative therapies for the most severe forms of asthma and tuberculosis. For this we will use experimentalmodels asthma and pneumonia caused by pneumococcus, obesity and tuberculosis, diabetes and tuberculosis, which are comorbidities associated with the immunopathology of both diseases. To complement the pre-clinical studies, trialswith samples of patients with asthma or tuberculosis are also contemplated in this Proposal in order to prove the existence of correlations between risk factors, such asdiagnosis of diabetes or infection with pneumococcus, and outcomes: genes associated with the inflammatory response. The second clearly defined objective is the training of human resources and the development of quality research with translational potential. In this way we seek the intellectual, ethical, scientific andcritical training to obtain innovative and consistent results that can positively affect the diffusion of Brazilian science to the world. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE CAMPOS FRAGA-SILVA, THAIS FERNANDA; MUNHOZ-ALVES, NATALIA; NISHIYAMA MIMURA, LUIZA AYUMI; CARDOSO DE OLIVEIRA, LARISSA RAGOZO; ALVES FIGUEIREDO-GODOI, LIVIA MARA; GARCIA, MAIRA TERRA; OLIVEIRA, EVELYN SILVA; WATANABE ISHIKAWA, LARISSA LUMI; GONCALVES ZORZELLA-PEZAVENTO, SOFIA FERNANDA; DEPERON BONATO, VANIA LUIZA; et al. Systemic Infection by Non-albicans Candida Species Affects the Development of a Murine Model of Multiple Sclerosis. JOURNAL OF FUNGI, v. 8, n. 4, p. 19-pg., 2022-04-01. (19/11213-1)

FUMAGALLI, MARCILIO JORGE; CASTRO-JORGE, LUIZA ANTUNES; FRAGA-SILVA, THAIS FERNANDA DE CAMPOS; DE AZEVEDO, PATRICK ORESTES; CAPATO, CARLOS FABIANO; RATTIS, BRUNA AMANDA CRUZ; HOJO-SOUZA, NATALIA SATCHIKO; FLORIANO, VITOR GONCALVES; DE CASTRO, JULIA TEIXEIRA; RAMOS, SIMONE GUSMAO; et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses-Basel, v. 13, n. 12, DEC 2021. (19/26119-0, 20/05527-0, 18/09383-3, 19/09881-6, 19/11213-1)

RODRIGUES, DANIEL; MACHADO, MIRELE R.; ALVES, JULIANO V.; FRAGA-SILVA, THAIS F. C.; MARTINS, RONALDO B.; CAMPOS, LIGIA C. B.; FRANCISCO, DANIELY F.; COUTO, ARIEL E. S.; BONATO, VANIA L. D.; ARRUDA, EURICO; et al. Cytokine storm in individuals with severe COVID-19 decreases endothelial cell antioxidant defense via downregulation of the Nrf2 transcriptional factor. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, v. 325, n. 2, p. 12-pg., 2023-08-01. (13/08216-2, 19/11213-1, 21/08847-9, 21/09273-6)