Diet, systemic inflammation and health outcomes in two different phenotypes of aging

• Grant number: 18/25368-4
• Support Opportunities: Regular Research Grants
• Start date: June 01, 2019
• End date: May 31, 2022
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Sandra Maria Lima Ribeiro
• Grantee: Sandra Maria Lima Ribeiro
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This study aims to investigate associations between diet, physical activity, low-grade systemic inflammation (LGSI) and biomarkers of aging in persons with different aging phenotypes: (a) persons living with HIV in use of antiretroviral therapy; (b) persons with mental disorders in use of specific medicines. Two independent studies will be performed, including: (a) persons registered at a specialized outpatient clinic directed to HIV management (SEAP/HCFMUSP); (b) persons registered at the drug dispensing service of Psychiatry Institute- HCFMUSP. Both studies intend to include 300 participants, with 50 participants included in each of the following age intervals: 18 to 29 years; 30 to 39 years; 40 to 49 years; 50 to 59 years; 60+ years. The variables to be investigated in both studies will be: general informations of health and lifestyle (data obtained from medical records and interviews; food intake and physical activity evaluation), energy metabolism (rest energy expenditure analysis), body composition and functionality (anthropometry, bioelectrical impedance, DEXA, sarcopenia and frailty prediction), intestinal health (by Bristol and Roma criteria), systemic inflammation and gut permeability (by plasma biomarkers), senescence of the immune system (by cytometry), and mental status (cognition and brain disturbances evaluation). Only for the HIV study, we will analyze the gut microbiome. In both studies, the data will be analyzed in three steps: (a) Variables will be compared according to age ranges; (b) All of the interest variables will be investigated for the association with the inflammatory dietary index (from the food intake informations); (c) Linear and/or logistic regression models, taking into account the results from item "b", and as independent variables the inflammatory dietary index, together with the gender, the age, the type of medicine used, and physical activity level. The results of this study, besides constituting a source of informations about these aging groups, will allow the development of non-pharmacological interventions to control the LGSI and the aging symptoms in these groups. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

QUARESMA, MARCUS V. L. DOS SANTOS; DE MELO, CAMILA MARIA; RIBEIRO, SANDRA MARIA LIMA. Effect of proteins, amino acids, and other nitrogenated supplements on the skeletal muscle mass in people living with HIV (PLWH): A systematic review. CLINICAL NUTRITION ESPEN, v. 51, p. 14-pg., 2022-10-01. (18/25368-4)

VICENTE, BEATRIZ M.; NETO, JOAO VALENTINI; DOS SANTOS QUARESMA, MARCUS VINICIUS L.; VASCONCELOS, JANAINA SANTOS; BAUCHIUNAS, ROSELI ESPINDOLA; DOS SANTOS, ELISABETE C. M.; PICONE, CAMILA M.; IBRAHIM, KARIM Y.; AVELINO-SILVA, VIVIAN, I; DE MELO, CAMILA M.; et al. Covid-19 Social Distancing, Lifestyle and Health Outcomes Among Persons Living with HIV (PLWH): A Web-based Survey. AIDS AND BEHAVIOR, v. N/A, p. 12-pg., 2022-06-14. (18/25368-4)

DOS-SANTOS-QUARESMA, MARCUS V. L.; LIMA-RIBEIRO, SANDRA M.. Sarcopenia in persons living with HIV under antiretroviral therapy: Literature review. AIDS REVIEWS, v. 24, n. 1, p. 15-pg., 2022-01-01. (18/25368-4)