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Diet, systemic inflammation and health outcomes in two different phenotypes of aging

Grant number: 18/25368-4
Support type:Regular Research Grants
Duration: June 01, 2019 - May 31, 2021
Field of knowledge:Health Sciences - Collective Health - Public Health
Principal Investigator:Sandra Maria Lima Ribeiro
Grantee:Sandra Maria Lima Ribeiro
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

This study aims to investigate associations between diet, physical activity, low-grade systemic inflammation (LGSI) and biomarkers of aging in persons with different aging phenotypes: (a) persons living with HIV in use of antiretroviral therapy; (b) persons with mental disorders in use of specific medicines. Two independent studies will be performed, including: (a) persons registered at a specialized outpatient clinic directed to HIV management (SEAP/HCFMUSP); (b) persons registered at the drug dispensing service of Psychiatry Institute- HCFMUSP. Both studies intend to include 300 participants, with 50 participants included in each of the following age intervals: 18 to 29 years; 30 to 39 years; 40 to 49 years; 50 to 59 years; 60+ years. The variables to be investigated in both studies will be: general informations of health and lifestyle (data obtained from medical records and interviews; food intake and physical activity evaluation), energy metabolism (rest energy expenditure analysis), body composition and functionality (anthropometry, bioelectrical impedance, DEXA, sarcopenia and frailty prediction), intestinal health (by Bristol and Roma criteria), systemic inflammation and gut permeability (by plasma biomarkers), senescence of the immune system (by cytometry), and mental status (cognition and brain disturbances evaluation). Only for the HIV study, we will analyze the gut microbiome. In both studies, the data will be analyzed in three steps: (a) Variables will be compared according to age ranges; (b) All of the interest variables will be investigated for the association with the inflammatory dietary index (from the food intake informations); (c) Linear and/or logistic regression models, taking into account the results from item "b", and as independent variables the inflammatory dietary index, together with the gender, the age, the type of medicine used, and physical activity level. The results of this study, besides constituting a source of informations about these aging groups, will allow the development of non-pharmacological interventions to control the LGSI and the aging symptoms in these groups. (AU)