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Effects of electrical stimulation on the prevention of muscle mass loss in patients with sepsis and septic shock: a randomized, controlled, double-blind clinical trial

Abstract

Electrical stimulation has been used in critical patients as an adjunct strategy of early rehabilitation. In septic or septic shock patients there are reports of only two studies in the literature, with conflicting results.Objective: To evaluate the effects of electrical stimulation in the prevention of muscle mass loss in patients admitted to the ICU with sepsis or septic shock.Methods: This is a randomized, controlled, double-blind clinical trial. Thirty-six patients with a diagnosis of sepsis or septic shock in the experimental group (high frequency electrical stimulation) and sham group will be randomized. They will be evaluated in relation to muscle mass, peripheral muscle strength and functional status. They will also be submitted to the collection of inflammatory, metabolic, damage and muscular trophism markers.Expected results: Electrical stimulation is expected to be able to prevent loss of muscle mass in patients admitted to the ICU with sepsis or septic shock. In addition, it is expected to be able to preserve strength and functional status in this population without increasing the pro-inflammatory or metabolic response. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ANDRADE-JUNIOR, MARIO CHUEIRE DE; SALLES, ISABEL CHATEAUBRIAND DINIZ DE; DE BRITO, CHRISTINA MAY MORAN; PASTORE-JUNIOR, LAERTE; RIGHETTI, RENATO FRAGA; YAMAGUTI, WELLINGTON PEREIRA. Skeletal Muscle Wasting and Function Impairment in Intensive Care Patients With Severe COVID-19. FRONTIERS IN PHYSIOLOGY, v. 12, . (18/16832-9)
RENATO FRAGA RIGHETTI; MIRIAN AKEMI ONOUE; FLAVIA VANESSA AUREA POLITI; DÉBORA TRIGO TEIXEIRA; PATRICIA NERY DE SOUZA; CLAUDIA SEIKO KONDO; ELIANA VIEIRA MODERNO; IGOR GUTIERREZ MORAES; ANA LÍGIA VASCONCELLOS MAIDA; LAERTE PASTORE JUNIOR; et al. Physiotherapy Care of Patients with Coronavirus Disease 2019 (COVID-19) - A Brazilian Experience. Clinics, v. 75, p. -, . (18/16832-9)
BRITO, CAMILA PORTO; MORAES, IGOR GUTIERREZ; LUDERS, CLAUDIO; DE BRITO, CHRISTINA MAY MORAN; YAMAGUTI, WELLINGTON PEREIRA. Relationship of phase angle and peak torque of knee extensors with the performance in six-minute step test in haemodialysis patients. BMC Nephrology, v. 22, n. 1, . (18/16832-9)
DE BARROS, CASSIA FABIANE; FELISBERTO, ROSIMEIRE MARCOS; ALBANEZI NUCCI, KELLY CRISTINA; PEREIRA DE ALBUQUERQUE, ANDRE LUIS; PAULIN, ELAINE; MORAN DE BRITO, CHRISTINA MAY; YAMAGUTI, WELLINGTON PEREIRA. Dynamic hyperinflation induced by the 6-minute pegboard and ring test in hospitalized patients with exacerbated COPD. PLoS One, v. 15, n. 11, . (18/16832-9)

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