Yellow fever and influenza 2018 vaccination campaign: safety and immunogenicity in patients with rheumatological autoimmune diseases

• Grant number: 18/16162-3
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2019
• End date: September 30, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Ferreira Borba Neto
• Grantee: Eduardo Ferreira Borba Neto
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Clovis Artur Almeida da Silva ; Eloisa Silva Dutra de Oliveira Bonfá ; Nádia Emi Aikawa ; Sandra Gofinet Pasoto

Abstract

The prognosis of autoimmune rheumatic diseases (ARD) has improved considerably with the advent of specific therapies, but infections are still a relevant cause of morbidity and mortality in this population. Immunization is therefore an important tool for infection prevention in this group of patients. The 2018 flu vaccination campaign was reinforced by the fact that in the US, there was a predominance of severe influenza A(H3N2) viruses infection that caused a significant number of hospitalizations and deaths. In that same year, the WHO included the State of São Paulo as an area of risk for yellow fever and the Societies of Specialists (Rheumatology, Immunization, Infectious Disease and Tropical Medicine) issued a technical note recommending vaccination to ARD patients who were under low degree of immunosuppression during the Vaccination Campaign. There are, however, no prospective controlled studies on immunogenicity, risk of adverse events and risk of activation of the disease by yellow fever and A/Singapore/INFIMH-16-0019/2016 A(H3N2)-like virus vaccines in patients with ARD. Thus, during the two campaigns carried out in the HC complex, patients with several autoimmune rheumatic diseases that were regularly followed in the HCFMUSP Rheumatology Unit and Pediatric Rheumatology Unit of the HCFMUSP Children's Institute and healthy controls were invited to participate in the study. For the Yellow Fever Campaign, we included healthy controls matched for sex/age and only patients with low immunosuppression [(rheumatoid arthritis (RA), spondyloarthritis, systemic lupus erythematosus (SLE), dermatomyositis (DM), mixed connective tissue disease, systemic vasculitis, systemic sclerosis (SS), primary Sjögren's syndrome (pSS), antiphospholipid syndrome (APS), juvenile idiopathic arthritis and juvenile SLE]. The subjects were evaluated clinically on the day of the vaccine (fractionated), 5, 10 and 30-45 days post-vaccination and at the same dates laboratory exams were collected for evaluation of adverse effects, viremia, immunogenicity and parameters of activity of each of diseases (patients only). For the annual influenza vaccination campaign 2018, with the inactivated and fragmented influenza vaccine [A/Michigan/45/2015 A(H1N1)pdm09-like virus, A/Singapore/INFIMH-16-0019/2016 A(H3N2)-like virus; B/ Phuket/3073/2013-like virus]. Healthy controls were matched for sex/age and patients with SLE (adult and juvenile) and pSS were included. All were evaluated clinically on the day of the vaccine and after 30-45 days post-vaccination and at the same dates laboratory exams were collected for evaluation of adverse effects, immunogenicity and parameters of activity of each disease (only patients). (AU)

Scientific publications

(10)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy & mdash;Is there a link?. NUTRITION, v. 85, MAY 2021. (18/16162-3, 15/03756-4)

AIKAWA, NADIA EMI; BALBI, VERENA ANDRADE; BORBA, EDUARDO FERREIRA; TONACIO, ADRIANA CORACINI; SALLUM, ADRIANA MALUF ELIAS; CAMPOS, LUCIA MARIA ARRUDA; KOZU, KATIA TOMIE; VENDRAMINI, MARGARETE BORGES; FONTOURA, NICOLE; AZEVEDO, ADRIANA DE SOUZA; et al. Yellow fever vaccination in Brazil: Short-term safety and immunogenicity in juvenile autoimmune rheumatic diseases. VACCINE: X, v. 10, p. 4-pg., 2022-04-01. (15/03756-4, 18/16162-3)

CLAUDINO FORMIGA, FRANCISCO FELLIPE; SILVA, CLOVIS ARTUR; PEDROSA, TATIANA DO NASCIMENTO; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; GARCIA, CRISTIANA COUTO; VIDAL CAPAO, ARTUR SILVA; DE OLIVEIRA MARTINS, VICTOR ADRIANO; TONACIO DE PROENCA, ADRIANA CORACINI; FULLER, RICARDO; et al. Influenza A/Singapore (H3N2) component vaccine in systemic lupus erythematosus: A distinct pattern of immunogenicity. Lupus, v. 30, n. 12, AUG 2021. (18/09937-9, 17/14352-7, 10/10749-0, 15/03756-4, 18/16162-3)

MUNHOZ, GABRIELA A.; AIKAWA, NADIA E.; SILVA, CLOVIS A.; PASOTO, SANDRA G.; PEDROSA, TATIANA N.; SEGURO, LUCIANA P. C.; BONFA, ELOISA; BORBA, EDUARDO F.. Short-term Accrual 2019 European League Against Rheumatism/American College of Rheumatology Domains and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage in Lupus Patients With and Without Nephritis at Disease Onset. JCR-JOURNAL OF CLINICAL RHEUMATOLOGY, v. 29, n. 4, p. 6-pg., 2023-06-01. (17/14352-7, 18/16162-3, 15/03756-4)

BALMANT, BIANCA D.; TORRINHAS, RAQUEL S.; ROCHA, ILANNA M.; FONSECA, DANIELLE C.; FORMIGA, FRANCISCO F. C.; BONFA, ELOISA S. D. O.; BORBA, EDUARDO F.; WAITZBERG, DAN L.. SARS-CoV-2 infection, gut dysbiosis, and heterogeneous clinical results of hydroxychloroquine on COVID-19 therapy-Is there a link?. NUTRITION, v. 85, p. 3-pg., 2021-02-02. (18/16162-3, 15/03756-4)

NADIA EMI AIKAWA; EDUARDO FERREIRA BORBA; VERENA ANDRADE BALBI; ADRIANA MALUF ELIAS SALLUM; IZABEL MANTOVANI BUSCATTI; LUCIA MARIA ARRUDA CAMPOS; KÁTIA TOMIE KOZU; CRISTIANA COUTO GARCIA; ARTUR SILVA VIDAL CAPÃO; ADRIANA CORACINI TONACIO DE PROENÇA; et al. Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus. ADVANCES IN RHEUMATOLOGY, v. 63, 2023-12-18. (17/14352-7, 18/16162-3, 15/03756-4, 10/10749-0)

TONACIO, ADRIANA CORACINI; PEDROSA, TATIANA DO NASCIMENTO; BORBA, EDUARDO FERREIRA; AIKAWA, NADIA EMI; PASOTO, SANDRA GOFINET; RENTE FERREIRA FILHO, JULIO CESAR; SAMPAIO BARROS, MARILIA MANTOVANI; LEON, ELAINE PIRES; FERREIRA SPINA LOMBARDI, SUZETE CLEUSA; MENDRONE JUNIOR, ALFREDO; et al. mmunogenicity and safety of primary fractional-dose yellow fever vaccine in autoimmune rheumatic disease. PLoS Neglected Tropical Diseases, v. 15, n. 11, NOV 2021. (10/10749-0, 17/14352-7, 18/16162-3, 17/11516-9)

INSFRAN, CARLOS E.; AIKAWA, NADIA E.; PASOTO, SANDRA G.; FILHO, DILSON M. N.; FORMIGA, FRANCISCO F. C.; PITTA, ANA C.; BORBA, EDUARDO F.; RIBEIRO, CAROLINA T.; SILVA, CLOVIS A.; BONFA, ELOISA. 2019-EULAR/ACR classification criteria domains at diagnosis: predictive factors of long-term damage in systemic lupus erythematosus. CLINICAL RHEUMATOLOGY, NOV 2021. (18/16162-3, 15/03756-4)

CLAUDINO FORMIGA, FRANCISCO FELLIPE; SILVA, CLOVIS ARTUR; DO NASCIMENTO PEDROSA, TATIANA; AIKAWA, NADIA; GARCIA, CRISTIANA COUTO; CAPAO, ARTUR; DE OLIVEIRA MARTINS, VICTOR ADRIANO; DE PROENCA, ADRIANA CORACINI TONACIO; FULLER, RICARDO; VIEIRA NEVES YUKI, EMILY FIGUEIREDO; et al. Influenza A(H3N2)/Singapore Component Vaccine in Systemic Lupus Erythematosus: A Distinct Pattern of Immunogenicity. ARTHRITIS & RHEUMATOLOGY, v. 73, p. 1-pg., 2021-09-01. (18/16162-3)

PASOTO, SANDRA GOFINET; BORBA, EDUARDO FERREIRA; FORMIGA, FRANCISCO FELLIPE CLAUDINO; DO NASCIMENTO PEDROSA, TATIANA; AIKAWA, NADIA EMI; DE SIQUEIRA, MARILDA AGUDO MENDONCA TEIXEIRA; CAPAO, ARTUR SILVA VIDAL; DE PROENCA, ADRIANA CORACINI TONACIO; FULLER, RICARDO; YUKI, EMILY FIGUEIREDO NEVES; et al. Robust immunogenicity to the H3N2 component of influenza A vaccine in primary Sjogren syndrome. CLINICAL RHEUMATOLOGY, v. 42, n. 9, p. 7-pg., 2023-06-12. (17/14352-7, 18/16162-3, 15/03756-4)