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Evaluation of photoactivity of porphyrin-conjugated ternary quantum dots

Grant number: 19/20111-8
Support type:Research Grants - Visiting Researcher Grant - International
Duration: January 03, 2020 - January 23, 2020
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Dayane Batista Tada
Grantee:Dayane Batista Tada
Visiting researcher: Samuel Oluwatobi Oluwafemi
Visiting researcher institution: University of Johannesburg (UJ), South Africa
Home Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Federal de São Paulo (UNIFESP). Campus São José dos Campos. São José dos Campos , SP, Brazil

Abstract

The conjugation of a photosensitizer (PS) to a nanoparticle (NP) creates the well-known photosensitizing nanoparticles which have been widely explored for application in Photodynamic Therapy (PDT). In comparison with the application of a PS in solution, the use of photosensitizing NPs provides improved tumor targeting and circulation time. Also, photosensitizing NPs can enhance therapeutic efficiency of PS by protecting them from deactivation as well as by avoiding PS aggregation and providing the modulation of PS photoactivity. In addition to these advantages the development of a photosensitizing NP by conjugating the PS to a ternary quantum dot will also enable the application of the NPs as agents for diagnosis by fluorescence. (AU)