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Impact of parathyroidectomy on sarcopenia and energy metabolism in patients with chronic kidney disease on dialysis and with secondary hyperparathyroidism

Grant number: 19/14583-4
Support type:Regular Research Grants
Duration: December 01, 2019 - November 30, 2021
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Rosa Maria Affonso Moysés
Grantee:Rosa Maria Affonso Moysés
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Ana Lúcia de Sá Pinto ; Bengt Lindholm ; Carla Maria Avesani ; Eduardo Jorge Duque de Sá Carneiro Filho ; Luciene Machado dos Reis ; Luzia Naoko Shinohara Furukawa ; Peter Stenvinkel ; Rosa Maria Rodrigues Pereira ; Rosilene Motta Elias Coelho ; Samuel Katsuyuki Shinjo ; Shirley Ferraz Crispilho ; Vanda Jorgetti

Abstract

Bone and mineral disorders in chronic kidney disease (CKD-BMD) involve abnormal metabolism of calcium and phosphorus, vitamin D deficiency, increased levels of fibroblast growth factor (FGF-23) and parathyroid hormone (PTH). These changes are associated with several complications in CKD patients, such as skeleton deformities and bone fractures. Recent researches point out the correlation of hyperparathyroidism with inflammation, cardiovascular disease, sleep disorders, increased energy expenditure, and sarcopenia. Experimental studies in murine have demonstrated the role of PTH receptor on the development of sarcopenia related to cancer and chronic kidney disease. We hypothesize that PTH influences energy expenditure, and parathyroidectomy (PTX), a treatment for severe hyperparathyroidism, improves muscle mass and modifies basal energy expenditure in CKD patients. (AU)