Modeling the host response to dengue virus and Antibody Dependent Enhancement
| Grant number: | 19/23202-4 |
| Support type: | Research Grants - Visiting Researcher Grant - International |
| Duration: | December 07, 2019 - December 20, 2019 |
| Field of knowledge: | Physical Sciences and Mathematics - Mathematics - Applied Mathematics |
| Principal Investigator: | Cláudia Pio Ferreira |
| Grantee: | Cláudia Pio Ferreira |
| Visiting researcher: | Maria de Lourdes Esteva |
| Visiting researcher institution: | Universidad Nacional Autónoma de México (UNAM), Mexico |
| Home Institution: | Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
Abstract
A mathematical model will be set up to describe the temporal evolution of dengue virus and human immune system during a second infection. The hypothesis is that specific and non-especific immunological cells compete by virus neutralization. The goal is to analyse two situation: when the infection is controlled by the immune system; and when the infection is enhanced by the immune cells generated after a primary response with a different virus. (AU)