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Modelling the dengue hemorrhagic fever

Grant number: 19/23202-4
Support type:Research Grants - Visiting Researcher Grant - International
Duration: December 07, 2019 - December 20, 2019
Field of knowledge:Physical Sciences and Mathematics - Mathematics - Applied Mathematics
Principal Investigator:Cláudia Pio Ferreira
Grantee:Cláudia Pio Ferreira
Visiting researcher: Maria de Lourdes Esteva
Visiting researcher institution: Universidad Nacional Autónoma de México (UNAM), Mexico
Home Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

A mathematical model will be set up to describe the temporal evolution of dengue virus and human immune system during a second infection. The hypothesis is that specific and non-especific immunological cells compete by virus neutralization. The goal is to analyse two situation: when the infection is controlled by the immune system; and when the infection is enhanced by the immune cells generated after a primary response with a different virus. (AU)