Preliminary study of viability and histopathological changes of the neural structures in a thermal insulating model of the spinal canal during percutaneous cone beam computed tomography guided vertebral cryoablation in swine

• Grant number: 18/24142-2
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2019
• End date: November 30, 2021
• Field of knowledge: Health Sciences - Medicine - Medical Radiology
• Principal Investigator: José Guilherme Mendes Pereira Caldas
• Grantee: José Guilherme Mendes Pereira Caldas
• Host Institution: Instituto de Radiologia (INRAD). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Alessandro Rodrigo Belon ; Celi Santos Andrade ; Ricardo Miguel Costa de Freitas

Abstract

The aim of this study is to evaluate the viability, reproducibility and safety of the cone beam computed tomography guided percutaneous vertebral cryoablation in a swine model, by means of the spinal canal thermal protection with the help of a mechanical device associated with the carbon dioxide (CO2). The histopathological changes will be observed in the acute and subacute phases (05 days). The evaluation criteria of the spinal cord protection during vertebral cryoablation include the easiness of the vertebrae and the spinal canal access, the ability to define the beginning and end of the cryoablation, the protection device visibility in the spinal canal, the freezing protocol, the depth and length of the vertebral freezing as well as neural structures preservation after the vertebral freezing. (AU)