Study of adhesion and proliferation of stem cells in capacitive electrical stimuli over scaffolds in 2D and 3D made by electrospinning and Solution Blow Spinning

• Grant number: 19/15781-4
• Support Opportunities: Regular Research Grants
• Duration: December 01, 2019 - November 30, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Convênio/Acordo: University of Manchester
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Susana Inés Córdoba de Torresi
• Grantee: Susana Inés Córdoba de Torresi
• Principal researcher abroad: Sarah Cartmell
• Institution abroad: University of Manchester, England
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated researchers: Jonathan James Blaker ; Roberto Manuel Torresi
• Associated research grant: 18/13492-2 - Synthetic and natural scaffolds applied to regenerative medicine, AP.TEM

Abstract

The aim of this project is to swap knowledge and expertise in scaffolds with 2D and 3D structures built up by electrospinning and solution blow spinning using PEDOT-co-PDLLA in the molar proportion PEDOT: PDLLA 1:50, 1:25 and 1:5. It is expected material maintain their features associated with electroactive, biocompatible and biodegradable properties. The two kinds of scaffold could have macro-/microporous bers with 3D interconnected pores, which is ideal to apply in stem cells at capacitive electrical stimuli. Our objective is to build a collaboration between the two partners to propose a protocol for preparing such surfaces without involving costlier 2D and 3D build techniques. (AU)