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Genetic and molecular landscape in Chagas Disease cardiomyopathy: therapeutic and prognostic targets

Grant number: 19/22327-8
Support type:Research Grants - Visiting Researcher Grant - International
Duration: February 15, 2020 - March 01, 2020
Field of knowledge:Biological Sciences - Immunology - Applied Immunology
Principal Investigator:Edecio Cunha Neto
Grantee:Edecio Cunha Neto
Visiting researcher: Christophe Chevillard
Visiting researcher institution: Aix-Marseille Université (AMU), France
Home Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
Associated research grant:14/50890-5 - INCT of Investigation in Immunology, AP.TEM


Dr Christophe Chevillard's scientific visit is crucial for the collaborative scientific program, which so far has shown to be very productive. It allowed publication of 14 scientific papers, 5 in various steps of writing; 7 supported grant proposals (two currently submitted and awaiting review). We will perform additional analysis and processing of data obtained in FAPESP/ANR collaborative grant FAPESP 2013/50302-3 and data obtaining since the end of the grant in 2018. This kind of large-scale integration of multiple layers of gene and protein expression control has seldom been done to explore the pathogenesis of human disease, and never in Chagas disease cardiomyopathy. We will finalize writing manuscripts and advancing grant proposals to continue the study on the grant theme of this application. During the visit we will review the final steps of the FAPESP Tematico grant application "Genetic and molecular landscape in Chagas Disease Cardiomyopathy: Therapeutic and Prognostic Targets". This will include meetings with other partners of the multicentric cohort as well as new partners of the future proposal, working on mitochondrial biology, iPS generation and electrophysiology, multi-omics analysis and single-cell transcriptome analysis, who are located in São Paulo. In addition to the Chagas area, Dr Chevillard will discuss exome sequencing approaches to other diseases under the study of the Division of Clinical Immunology and Alergy, FMUSP, like yellow fever, neurological adverse effects after yellow fever vaccination, and common variable immunodeficiency. (AU)