Study of 17-beta-estradiol treatment on lung injury caused by occlusion of the proximal descending aorta in male rats

• Grant number: 18/25759-3
• Support Opportunities: Regular Research Grants
• Duration: November 01, 2019 - April 30, 2022
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Ana Cristina Breithaupt Faloppa
• Grantee: Ana Cristina Breithaupt Faloppa
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Cristiano de Jesus Correia ; Luiz Felipe Pinho Moreira

Abstract

Surgical procedures involving aortic obstruction may present complications, such as ischemia and reperfusion injury. This clinical condition consists of the occlusion of the blood flow and its subsequent return to the tissue, resulting in hemodynamic changes, activation of the immune system and, in extreme cases, severe tissue lesions. Some inflammatory responses are so exacerbated that, instead of benefiting the individual, they play a pathogenic role and lead the patient to death or rejection of the graft in the case of transplants. The lung is one of the organs most affected by the effects of ischemia and reperfusion. However, recent studies have shown that sex hormones, especially estradiol, have a protective effect and attenuate the inflammatory process. Estradiol has been shown to modulate several immune cells, suggesting that estrogens play a key role in immunocompetence. It is important to emphasize that estradiol protects the cardiovascular system against ischemic, inflammatory and metabolic injuries. Thus, this study aims to investigate the possible anti-inflammatory effects of estradiol in ischemia and pulmonary reperfusion injury caused by aortic occlusion in male rats. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA ANUNCIACAO, LUCAS FERREIRA; DE SOUSA, MARCELO NUNES; VIDAL-DOS-SANTOS, MARINA; ARMSTRONG-JR, ROBERTO; PINHO MOREIRA, LUIZ FELIPE; CORREIA, CRISTIANO JESUS; BREITHAUPT-FALOPPA, ANA CRISTINA. Modulatory effects of 17?-estradiol on acute lung inflammation after total occlusion of the descending aorta in male rats. International Immunopharmacology, v. 113, p. 9-pg., 2022-10-14. (21/07455-0, 18/25759-3, 20/11211-6)