Advanced search
Start date
Betweenand

Plasma pharmacokinetics and tissue biodistribution of lipid-based nanoformulations

Grant number: 19/17784-0
Support type:Regular Research Grants
Duration: January 01, 2020 - December 31, 2021
Field of knowledge:Biological Sciences - Pharmacology - Biochemical and Molecular Pharmacology
Cooperation agreement: CONFAP - National Council of State Research Support Foundations
Principal Investigator:Eneida de Paula
Grantee:Eneida de Paula
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers: BIBIANA VERLINDO DE ARAUJO

Abstract

Nanostructured lipid carriers (CLN) are suitable for the encapsulation of hydrophobic drugs, offering a series of advantages over other drug-delivery carriers such as: biocompatibility, biodegradability, non-immunogenicity, relative low cost, no requirement of organic solvents and scalability. Aiming to stablish a collaborative research network between the Biomembranes laboratory (Unicamp) and the Pharmacokinetics and PK/PD Modeling Laboratory (UFRGS) in the biotechnological area, this project intends to evaluate the pharmacokinetics, as well as the free drug concentrations of CLN-encapsulated drugs at target tissues using microdialysis. Two types of drug delivery systems will be investigated in animal models of disease: CLN containing either doxorrubicin or a photosensitizer agent for the treatment of breast cancer - using chemo or photodynamic therapy - and CLN uploaded with articaine for the anesthesia of inflamed tissue. (AU)