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Effect of diabetes and insulin on the production and activity of key enzymes of energetic metabolism of the submandibular gland of rats

Grant number: 19/14556-7
Support type:Regular Research Grants
Duration: March 01, 2020 - February 28, 2022
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Fernando Neves Nogueira
Grantee:Fernando Neves Nogueira
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Carla Renata Sipert


Saliva is an important fluid for the maintenance of oral homeostasis. It is produced and secreted by the salivary glands. The submandibular gland plays a major role in this process by contributing about 60% of the total secreted saliva during the rest. This salivary gland uses glucose as the main source of energy, and the Krebs cycle as the source of amino acids for protein synthesis. In diabetic rats we have already shown a reduction in the activity of glycolysis and the Krebs cycle and a decrease in the mucin concentration of saliva at rest, without reduction of salivary flow. These findings show the relationship between energy metabolism and salivary secretion. Associated with this, there is no information regarding the use of lipids as an energetic source of this gland, despite the importance of this pathway in the diabetic state in other tissues. Knowing the important role of insulin as a positive effector in several enzymes and the huge and severe systemic changes due to hyperglycemia in the diabetic state, the objective of this study is to verify the effect of diabetes and insulin on the expression, quantity and activity of key enzymes of glycolytic metabolism, glycogen metabolism, Krebs cycle and lipid metabolism in the submandibular glands of diabetic rats induced by streptozotocin and its controls, and the role of insulin in the possible alterations found in these groups. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARLUS DA SILVA PEDROSA; CARLA RENATA SIPERT; FERNANDO NEVES NOGUEIRA. Salivary Glands, Saliva and Oral Findings in COVID-19 Infection. Pesquisa Brasileira em Odontopediatria e Clínica Integrada, v. 20, p. -, 2020. Web of Science Citations: 0.

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