Determining molecular candidates that contribute to the higher risk of COVID-19 in aged individuals

• Grant number: 20/04919-2
• Support type: Regular Research Grants
• Duration: May 01, 2020 - April 30, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal researcher: Marcelo Alves da Silva Mori
• Grantee: Marcelo Alves da Silva Mori
• Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Assoc. researchers: Lucia da Conceição Andrade ; Robson Francisco Carvalho
• Associated research grant: 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics, AP.TEM
• Associated scholarship(s): 21/10373-5 - Using pre-clinical models to determine molecular candidates that contribute to the higher risk of COVID-19 during aging, BP.PD; 20/08716-9 - Using pre-clinical models to determine molecular candidates that contribute to the higher risk of COVID-19 during aging, BP.PD

Abstract

COVID-19 has recently emerged as an age-related disease whose mechanisms are still poorly understood. Using a combination of hypothesis-oriented and unsupervised, data-driven approaches, as well as patients and pre-clinical models, we expect to come up with candidate proteins and pathways which could not only predict the susceptibility to the disease, but also unveil the molecular mechanisms through which aging contributes to SARS-Cov-2 infection. We also expect to provide candidate FDA and ANVISA approved drugs which could potentially target these pathways to prevent, mitigate or eliminate virus infection. Our overarching aim is to elucidate how aging constitutes the main risk factor for COVID-19, providing potential solutions to its pandemic. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PASCOAL, LIVIA BITENCOURT; RODRIGUES, PATRICIA BRITO; GENARO, LIVIA MOREIRA; DOS SANTOS PEREIRA GOMES, ARILSON BERNARDO; TOLEDO-TEIXEIRA, DANIEL AUGUSTO; PARISE, PIERINA LORENCINI; BISPO-DOS-SANTOS, KARINA; SIMEONI, CAMILA LOPES; GUIMARAES, PAULA VERI; BUSCARATTI, LUCAS ILDEFONSO; DE ANGELI ELSTON, JOAO GABRIEL; MARQUES-SOUZA, HENRIQUE; MARTINS-DE-SOUZA, DANIEL; SETSUKO AYRIZONO, MARIA DE LOURDES; VELLOSO, LICIO AUGUSTO; PROENCA-MODENA, JOSE LUIZ; MENDES MORAES-VIEIRA, PEDRO MANOEL; SILVA MORI, MARCELO ALVES; FARIAS, ALESSANDRO SANTOS; RAMIREZ VINOLO, MARCO AURELIO; LEAL, RAQUEL FRANCO. Microbiota-derived short-chain fatty acids do not interfere with SARS-CoV-2 infection of human colonic samples. GUT MICROBES, v. 13, n. 1, p. 1-9, JAN 1 2021. Web of Science Citations: 0.