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Patients with Severe Acute Respiratory Syndrome due to COVID-19 in an emergency department

Grant number: 20/04738-8
Support type:Regular Research Grants
Duration: April 01, 2020 - March 31, 2022
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Heraldo Possolo de Souza
Grantee:Heraldo Possolo de Souza
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/14566-4 - Diagnostic and prognostic markers in patients admitted to an emergency department, AP.TEM

Abstract

The current Covid-19 pandemic has affected more than 920,000 people and killed more than 46,000 worldwide. Most affected patients have a mild condition, but a small percentage, from the percentage point of view, but large in absolute numbers, may have a severe acute respiratory syndrome (SARS), with fever, cough, pulmonary infiltrates and hypoxemia, and may progress for respiratory failure and need for mechanical ventilation. The Emergency Service of Hospital das Clínicas, Faculty of Medicine, University of São Paulo (HCFMUSP) is the current reference center for the treatment of patients with the most severe form of the disease. Our team is responsible for the initial care of these patients and, therefore, is well positioned to produce the knowledge necessary for a better understanding and treatment of this disease. In this way, we created this project, which consists of four subprojects. The first subproject aims to determine whether serum markers of the inflammatory response can predict, individually or in combination, the evolution of patients with SARS by Covid-19 for respiratory failure. The second seeks to determine whether pulmonary ultrasound is a viable alternative for assessing respiratory function in these patients. The third is a clinical trial with a drug already used in other clinical situations and which may be useful in preventing respiratory failure in patients with Covid-19 pneumonia. Finally, the fourth focuses on statistical and stochastic models, which can improve and guide the care of these patients. The study will be conducted at the Emergency Service of HCFMUSP, which is the gateway to the vast majority of patients with SARS by Covid-19. Patients with severe acute respiratory syndrome who do not require mechanical ventilation at admission will be included. In subprojects 1 and 2, these patients will only be followed up, without intervention, performing laboratory and ultrasound exams. In subproject 3, patients will be divided into two groups, one receiving NAC and the other placebo. In all three subprojects, the outcome will be mortality and the need for mechanical ventilation.In this pandemic moment, the search for a better understanding of the disease and treatments that can reduce the need for mechanical ventilation in these patients is extremely urgent and these are exactly the objectives of our project. (AU)

Matéria(s) publicada(s) na Agência FAPESP sobre o auxílio:
Lung ultrasound helps predict COVID-19 patient outcomes 
Articles published in other media outlets (104 total):
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Estadão.com: Ultrassom pulmonar ajuda a prever casos graves de covid-19 (19/Feb/2021)
Portal R7: Ultrassom pulmonar ajuda a prever evolução de casos graves de Covid-19 (26/Jan/2021)
UOL: Ultrassom pulmonar ajuda a prever evolução de pacientes com Covid-19 (22/Jan/2021)
CNN (Brasil): Ultrassom de pulmão ajuda a predizer evolução de pacientes com covid-19 (22/Jan/2021)
Andhravilas (Índia): Lung ultrasound may help predict Covid patient outcomes (17/Feb/2021)
Axis Imaging News (EUA): Lung ultrasound helps predict covid-19 patient outcomes (16/Feb/2021)
Medical Dialogues (Índia): Lung ultrasound helps predict covid-19 patient outcomes (15/Feb/2021)
The Hindu Business Line (Índia): Lung ultrasound can predict clinical progression of Covid-19 patients: Study (13/Feb/2021)
Daily World (Índia) online: Lung ultrasound may help predict Covid patient outcomes (12/Feb/2021)
Middle East North Africa Financial Network (Jordânia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Web India 123 (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Newsgram (EUA): Lung Ultrasound Can Also Predict Progression Of Severe Covid19 | NewsGram (11/Feb/2021)
Sify (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Daijiworld (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
IntraMed (Argentina): Ecografía pulmonar y evolución de pacientes con COVID-19 (11/Feb/2021)
DotMed (EUA): Lung ultrasound helps predict COVID-19 patient outcomes (11/Feb/2021)
Manorama Online (Índia): Ultrasound of lungs may help predict COVID patient outcomes: Study (11/Feb/2021)
Daily Hunt (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Social News (EUA): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Andhravilas (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
The Health Site (Índia): Lung ultrasound may help predict progression of COVID-19 to severe disease and death (11/Feb/2021)
NP News24 (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Sound Health and Lasting Wealth (Nigéria): Lung ultrasound may help predict progression of COVID-19 to severe disease and death (11/Feb/2021)
Bhaskar Live (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
British Asia News (Reino Unido): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
247 News Around The World: Lung ultrasound may help predict progression of COVID-19 to severe disease and death (11/Feb/2021)
Knowledia (França): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Andhram.com (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
IND News (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
NirogStreet (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
iLeon.com (Espanha): La ecografía pulmonar ayuda a predecir la evolución de los pacientes con covid (11/Feb/2021)
FloresHealth (Canadá): Lung ultrasound helps predict clinical progression of severe COVID-19 patients (11/Feb/2021)
Globe Health News: Lung ultrasound helps predict clinical progression of severe COVID-19 patients (11/Feb/2021)
Jhalak.com (EUA): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
TeluguSTOP (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
HospiMedica (EUA) online: Lung ultrasound helps predict clinical progression of severe COVID-19 patients (11/Feb/2021)
Revolverdeblake: Lung ultrasound helps predict clinical progression of severe COVID-19 patients (11/Feb/2021)
Sahara Samay (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Maha Media Online (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
5 Dariya News (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Just News Day: Lung ultrasound may predict your risk of severe disease (11/Feb/2021)
ITN- Imaging Technology News (EUA): Lung ultrasound helps predict COVID-19 patient outcomes (11/Feb/2021)
Daily 24x7 News (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
Argus News (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
India Narrative (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
All Me Blog (Índia): Lung ultrasound may help predict Covid patient outcomes (11/Feb/2021)
News Medical (Austrália): Lung ultrasound helps predict clinical progression of severe COVID-19 patients (10/Feb/2021)
Medical Xpress (Reino Unido): Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
Bioengineer (Reino Unido): Lung ultrasound helps predict COVID-19 patient outcomes. (10/Feb/2021)
Scienmag Science Magazine (Reino Unido): Lung Ultrasound Helps Predict COVID-19 Patient Outcomes (10/Feb/2021)
Brightsurf: Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
InfoSurHoy (EUA): Lung ultrasound helps predict COVID-19 patient outcomes. (10/Feb/2021)
Newkerala.com (Índia): Lung ultrasound may help predict Covid patient outcomes (10/Feb/2021)
7thSpace: Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
My Pharmacy News: Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
Hekim.pro Professional Doctors (Azerbaijão): Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
Sound Health and Lasting Wealth (Nigéria): Lung ultrasound helps predict clinical progression of severe COVID-19 patients (10/Feb/2021)
News Break (EUA): Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
Healthcare Hygiene Magazine (EUA): Lung ultrasound helps predict COVID-19 patient outcomes. (10/Feb/2021)
Corona Stocks (Canadá): Lung ultrasound helps predict COVID-19 patient outcomes. (10/Feb/2021)
pandemicsinfo.com: Lung ultrasound helps predict COVID-19 patient outcomes (10/Feb/2021)
Rota do Sertão: Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (31/Jan/2021)
Jornal Primeira Página online: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com Covid-19 - (28/Jan/2021)
Beto Ribeiro Repórter: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (28/Jan/2021)
Portal do Governo do Estado de São Paulo: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (27/Jan/2021)
Diário de Votuporanga online: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com Coronavírus (27/Jan/2021)
Acontece Botucatu : Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (27/Jan/2021)
Notícias ao Minuto: Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (27/Jan/2021)
Mix Vale: Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (27/Jan/2021)
Jornal Noroeste News: Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (27/Jan/2021)
Jornal de Itatiba online: Ultrassonografia pulmonar ajuda a predizer a evolução de infectados (27/Jan/2021)
Agência de Notícias – Defesa: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (27/Jan/2021)
Polêmica Paraíba: Ultrassom pulmonar ajuda a prever evolução de casos graves de Covid-19 (26/Jan/2021)
Portal Correio: Ultrassom pulmonar ajuda a prever evolução de casos graves de Covid-19 (26/Jan/2021)
Noticias de Contagem online: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (26/Jan/2021)
24 Brasil: Ultrassom pulmonar ajuda a prever evolução de casos graves de Covid-19 (26/Jan/2021)
2A+ Farma: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (26/Jan/2021)
Rádio Novo Horizonte FM 87.9: Ultrassom pulmonar ajuda a prever evolução de casos graves de Covid-19 (26/Jan/2021)
Medicina S/A: Ultrassonografia ajuda a predizer evolução de pacientes com Covid - Medicina S/A (25/Jan/2021)
Plantão News (MT): Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (25/Jan/2021)
Dom Total: Ultrassom pulmonar ajuda a prever a evolução de pacientes com Covid-19 (25/Jan/2021)
Tribuna União: Ultrassom pulmonar ajuda a prever a evolução de pacientes com Covid-19 (25/Jan/2021)
Saense: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (25/Jan/2021)
Na Cuia da Cris: Ultrassom dos pulmões pode prever agravamento de casos de Covid-19, diz pesquisa (25/Jan/2021)
DCM - Diário do Centro do Mundo: Ultrassom pulmonar ajuda a prever a evolução de pacientes com Covid-19 (24/Jan/2021)
Blog Jornal da Mulher: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (24/Jan/2021)
Martins em Pauta: Ultrassonografia pulmonar ajuda a prever evolução de pacientes com Covid-19 (23/Jan/2021)
Programa InfoSalud (Argentina): La ecografía pulmonar ayuda a predecir la evolución de pacientes con Covid-19 (23/Jan/2021)
MSN: Ultrassom de pulmão ajuda a predizer evolução de pacientes com covid-19 (22/Jan/2021)
BN - Bahia Notícias: Ultrassonografia pulmonar ajuda a prever evolução de pacientes com Covid-19 (22/Jan/2021)
NewsLab online: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (22/Jan/2021)
Galileu online: Ultrassom pulmonar ajuda a prever evolução de pacientes com Covid-19 (22/Jan/2021)
Planeta online: Ultrassom de pulmão ajuda a predizer evolução de pacientes com covid-19 (22/Jan/2021)
São Gonçalo Agora: Ultrassom dos pulmões pode prever agravamento de casos de Covid-19, diz pesquisa (22/Jan/2021)
Biblioteca FMUSP: Ultrassonografia de pulmão pode ajudar a prever a evolução clínica de pacientes com #COVID19 em estado grave, aponta estudo conduzido na Faculdade de Medicina da USP (22/Jan/2021)
Revista Tipo Manaus: Ultrassom dos pulmões pode prever agravamento de casos de Covid-19 (22/Jan/2021)
Bahia.ba: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com coronavírus (22/Jan/2021)
Bahia.ba: Pesquisa mostra que agravamento do coronavírus pode ser previsto com ultrassom (22/Jan/2021)
ABIPTI - Associação Brasileira das Instituições de Pesquisa Tecnológica e Inovação: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (22/Jan/2021)
Portal da Enfermagem: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (22/Jan/2021)
Recôncavo no Ar: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com coronavírus (22/Jan/2021)
Novo Cantu Notícias: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com COVID-19 (22/Jan/2021)
CCN News: Ultrassonografia pulmonar ajuda a predizer a evolução de pacientes com coronavírus (22/Jan/2021)
TV Conteúdo: Ultrassonografia pulmonar ajuda a prever evolução de pacientes com Covid-19 (22/Jan/2021)