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Clinical and epidemiological study of SARS-CoV-2 in a prospective population and hospitalar cohorts in São José do Rio Preto, SP, Brazil in 2020

Abstract

In a global context COVID-19 is the biggest health threat in the present days, because, in just over four months, the SARS-CoV-2 has spread to 171 countries reaching a pandemic status. Most patients with COVID-19 have a mild course of the disease, however, approximately 20% develop severe disease with a high mortality rate that is associated with age, comorbidities, and immunosuppression. Epidemiological studies are used to reveal the extent of viral spread in homes, communities, and hospitals. Thus, preventive and control measures can be established by the authorities. This project proposes to use a pre-established population cohort containing four years of data collection on the participants. The cohort is carried out in a restricted neighborhood in the municipality of São José do Rio Preto, located in the northwest region of the state of São Paulo. To this end, active participants in this study will be monitored for the appearance of symptoms related to COVID-19. A quick-access telephone number to the team will be made available in case of acute symptoms and, if necessary, referral to the local health service. Monitoring of hospitalized patients at the Hospital de Base of the Faculty of Medicine of São José do Rio Preto (FAMERP), who are suspected or confirmed by COVID-19, will also be carried out. Samples will be collected for further analysis of pro-inflammatory cytokines, possible biological markers that indicate worsening of the disease. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CANDIDO, DARLAN S.; CLARO, INGRA M.; DE JESUS, JAQUELINE G.; SOUZA, WILLIAM M.; MOREIRA, FILIPE R. R.; DELLICOUR, SIMON; MELLAN, THOMAS A.; DU PLESSIS, LOUIS; PEREIRA, RAFAEL H. M.; SALES, FLAVIA C. S.; et al. Evolution and epidemic spread of SARS-CoV-2 in Brazil. Science, v. 369, n. 6508, SI, p. 1255+, . (19/24251-9, 16/18445-7, 18/14933-2, 18/14389-0, 18/09383-3, 19/21301-5, 17/13981-0, 20/04836-0, 19/07544-2, 20/04558-0, 16/00194-8, 18/25468-9, 18/17176-8, 19/12000-1)
JIMENEZ, LEANDRO; CODO, ANA CAMPOS; SAMPAIO, VANDERSON DE SOUZA; OLIVEIRA, ANTONIO E. R.; KOBO FERREIRA, LUCAS KAORU; DAVANZO, GUSTAVO GASTAO; MONTEIRO, LAUAR DE BRITO; VIRGILIO-DA-SILVA, JOAO VICTOR; SILVA BORBA, MAYLA GABRIELA; DE SOUZA, GABRIELA FABIANO; et al. Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19. FRONTIERS IN MEDICINE, v. 8, . (18/14933-2, 20/04836-0)
ESTOFOLETE, CASSIA F.; MACHADO, LUANA F.; ZINI, NATHALIA; LUCKEMEYER, GRAZIELA D.; MORAES, MARILIA M.; DOS SANTOS, THAYSA M. I. L.; DOS SANTOS, BARBARA F.; RUIZ, LEONARDO G. P.; VASILAKIS, NIKOS; LOBO, SUZANA M. A.; et al. Presentation of fatal stroke due to SARS-CoV-2 and dengue virus coinfection. Journal of Medical Virology, v. 93, n. 3, p. 1770-1775, . (20/04836-0)
SACCHETTO, LIVIA; CHAVES, BARBARA APARECIDA; COSTA, EDSON RODRIGUES; DE MENEZES MEDEIROS, ALINE SOUZA; GORDO, MARCELO; ARAUJO, DANIELLE BASTOS; OLIVEIRA, DANIELLE BRUNA LEAL; DA SILVA, ANA PAULA BETARESSI; NEGRI, ANDREIA FRANCESLI; DURIGON, EDISON LUIZ; et al. Lack of Evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spillover in Free-Living Neotropical Non-Human Primates, Brazil. Viruses-Basel, v. 13, n. 10, . (20/04836-0)
BITTAR, CINTIA; POSSEBON, FABIO SOSSAI; ULLMANN, LEILA SABRINA; GERALDINI, DAYLA BOTT; DA COSTA, VIVALDO G.; DE ALMEIDA, LUIZ G. P.; SANCHES, PAULO RICARDO DA S.; NASCIMENTO-JUNIOR, NAILTON M.; CILLI, EDUARDO M.; BANHO, CECILIA ARTICO; et al. The Emergence of the New P.4 Lineage of SARS-CoV-2 With Spike L452R Mutation in Brazil. FRONTIERS IN PUBLIC HEALTH, v. 9, . (20/07419-0, 20/04836-0)
ESTOFOLETE, CASSIA F.; BANHO, CECILIA A.; CAMPOS, GUILHERME R. F.; MARQUES, BEATRIZ DE C.; SACCHETTO, LIVIA; ULLMANN, LEILA S.; POSSEBON, FABIO S.; MACHADO, LUANA F.; SYRIO, JULIANA D.; ARAUJO JUNIOR, JOAO P.; et al. Case Study of Two Post Vaccination SARS-CoV-2 Infections with P1 Variants in CoronaVac Vaccinees in Brazil. Viruses-Basel, v. 13, n. 7, . (20/04836-0)

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