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Study of the action of synthetic peptides as antivirals against SARS-CoV-2 (COVID-19) and combined evaluation with commercial anti-inflammatories

Grant number: 20/05761-3
Support type:Regular Research Grants
Duration: July 01, 2020 - June 30, 2022
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Eduardo Maffud Cilli
Grantee:Eduardo Maffud Cilli
Home Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Assoc. researchers:Cintia Bittar Oliva ; Marilia de Freitas Calmon ; Norival Alves Santos Filho ; Paula Rahal ; Paulo Ricardo da Silva Sanches
Associated research grant:17/24839-0 - Nanoelectronics and nanoscale electrochemistry: fundaments and applications, AP.TEM
Associated scholarship(s):20/12519-4 - Study of the action of synthetic peptides as antivirals against SARS-CoV-2 (COVID-19) and combined evaluation with commercial anti-inflammatories, BP.PD

Abstract

Human pandemics, emerging and re-emerging viruses and the mutation of viral strains have been highlighting the importance for antiviral research. Pandemics, such as the actual caused by SARS-CoV-2, directly affect the world, mainly the public health, economy, tourism, etc. Also, due his high and fast spreading, this disease are saturating hospitals worldwide and the number of deaths are increasing constantly. Due the actual severe global health problem caused by SARS-CoV-2 and moved for the urgency for the development of treatments for this disease and future pandemics, the search for new compounds to treat infections by SARS-Cov-2 represents an important research area. Therefore, the objective of this project is identify and evaluate potential peptides able to inhibit virus SARS-CoV-2 infection progression in different steps of virus replication in vitro such as virucidal, receptor binding and cytoplasmic replication. Peptides and bioconjugates have been showing high antiviral potential in different steps of virus lifecycle. According to antiviral activity, compounds will be classified within groups (Virucidal, Inhibitor of receptor binding and inhibitor of cytoplasmic replication) and the action mechanism will be elucidate. Additionally, selected peptides will be evaluated together with anti-inflammatories (Ibuprofen and Ketoprofen) to evaluate the combination of antiviral and anti-inflammatory therapies. (AU)

Articles published in other media outlets (15 total):
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A Cidade On (São Carlos, SP): Pesquisadores de Araraquara estudam proteína para combater o coronavírus (22/Jul/2020)
Central das Notícias: Pesquisadores de Araraquara estudam proteína para combater o coronavírus (22/Jul/2020)
Biblioteca FMUSP: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (20/Jul/2020)
Beto Ribeiro Repórter: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (20/Jul/2020)
Duna Press : Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (20/Jul/2020)
Diário do Rio Claro: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (19/Jul/2020)
Jornal Cidade - Rio Claro: Ação de 50 compostos sintéticos será testada (19/Jul/2020)
Região Noroeste : Ação de 50 compostos sintéticos será testada contra o Covid (18/Jul/2020)
Portal do Governo do Estado de São Paulo: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
São Carlos em Rede: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
Folha Nobre: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
Notícias de Campinas: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
Atemporal: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
Mix Vale: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)
O Verídico: Fapesp: Ação de 50 compostos sintéticos será testada contra o novo coronavírus (17/Jul/2020)