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Study of the action of synthetic peptides as antivirals against SARS-CoV-2 (COVID-19) and combined evaluation with commercial anti-inflammatories

Abstract

Human pandemics, emerging and re-emerging viruses and the mutation of viral strains have been highlighting the importance for antiviral research. Pandemics, such as the actual caused by SARS-CoV-2, directly affect the world, mainly the public health, economy, tourism, etc. Also, due his high and fast spreading, this disease are saturating hospitals worldwide and the number of deaths are increasing constantly. Due the actual severe global health problem caused by SARS-CoV-2 and moved for the urgency for the development of treatments for this disease and future pandemics, the search for new compounds to treat infections by SARS-Cov-2 represents an important research area. Therefore, the objective of this project is identify and evaluate potential peptides able to inhibit virus SARS-CoV-2 infection progression in different steps of virus replication in vitro such as virucidal, receptor binding and cytoplasmic replication. Peptides and bioconjugates have been showing high antiviral potential in different steps of virus lifecycle. According to antiviral activity, compounds will be classified within groups (Virucidal, Inhibitor of receptor binding and inhibitor of cytoplasmic replication) and the action mechanism will be elucidate. Additionally, selected peptides will be evaluated together with anti-inflammatories (Ibuprofen and Ketoprofen) to evaluate the combination of antiviral and anti-inflammatory therapies. (AU)

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Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
VENTURA FERNANDES, BIANCA H.; FEITOSA, NATALIA MARTINS; BARBOSA, ANA PAULA; BOMFIM, CAMILA GASQUE; GARNIQUE, ANALI M. B.; ROSA, IVANA F.; RODRIGUES, MAIRA S.; DORETTO, LUCAS B.; COSTA, DANIEL F.; CAMARGO-DOS-SANTOS, BRUNO; et al. oxicity of spike fragments SARS-CoV-2 S protein for zebrafish: A tool to study its hazardous for human health. Science of The Total Environment, v. 813, . (19/00195-2, 18/07098-0, 20/05761-3, 17/17303-7, 20/04680-0, 14/04294-1, 19/21739-0, 19/19939-1, 19/18356-2, 19/14285-3, 19/12234-2)
MENDONCA-GOMES, JULIANA MOREIRA; CHARLIE-SILVA, IVES; GUIMARAES, ABRAAO TIAGO BATISTA; ESTRELA, FERNANDA NEVES; CALMON, MARILIA FREITAS; MICELI, RAFAEL NAVA; SANCHES, PAULO R. S.; BITTAR, CINTIA; RAHAL, PAULA; CILLI, EDUARDO M.; et al. Shedding light on toxicity of SARS-CoV-2 peptides in aquatic biota: A study involving neotropical mosquito larvae (Diptera: Culicidae). Environmental Pollution, v. 289, . (19/19939-1, 20/05761-3)
FREIRE, MARJORIE C. L. C.; NOSKE, GABRIELA D.; BITENCOURT, NATALIA V.; SANCHES, PAULO R. S.; SANTOS-FILHO, NORIVAL A.; GAWRILJUK, VICTOR O.; DE SOUZA, EDUARDO P.; NOGUEIRA, VICTOR H. R.; DE GODOY, MARIANA O.; NAKAMURA, ALINE M.; et al. Non-Toxic Dimeric Peptides Derived from the Bothropstoxin-I Are Potent SARS-CoV-2 and Papain-like Protease Inhibitors. Molecules, v. 26, n. 16, . (18/17095-8, 20/04602-9, 13/07600-3, 20/05761-3, 20/12519-4, 18/25600-4, 16/19712-9, 16/13884-2, 18/13588-0)
SANCHES, PAULO R. S.; CHARLIE-SILVA, IVES; BRAZ, HELYSON L. B.; BITTAR, CINTIA; CALMON, MARILIA FREITAS; RAHAL, PAULA; CILLI, EDUARDO M.. Recent advances in SARS-CoV-2 Spike protein and RBD mutations comparison between new variants Alpha (B.1.1.7, United Kingdom), Beta (B.1.351, South Africa), Gamma (P.1, Brazil) and Delta (B.1.617.2, India). JOURNAL OF VIRUS ERADICATION, v. 7, n. 3, . (20/12519-4, 20/05761-3)
CHARLIE-SILVA, IVES; ARAUJO, AMANDA P. C.; GUIMARAES, ABRAAO T. B.; VERAS, FLAVIO P.; BRAZ, HELYSON L. B.; PONTES, LETICIA G. DE; JORGE, ROBERTA J. B.; BELO, MARCO A. A.; FERNANDES, BIANCA H. V.; NOBREGA, RAFAEL H.; et al. Toxicological insights of Spike fragments SARS-CoV-2 by exposure environment: A threat to aquatic health?. JOURNAL OF HAZARDOUS MATERIALS, v. 419, . (20/05761-3)

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