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Skin bioprinting as a plataform for alternative tests of efficacy and safety

Grant number: 19/14527-7
Support Opportunities:Regular Research Grants
Duration: March 01, 2020 - December 31, 2022
Field of knowledge:Health Sciences - Pharmacy
Principal Investigator:Silvya Stuchi Maria-Engler
Grantee:Silvya Stuchi Maria-Engler
Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated researchers:Ana Luíza Garcia Millás Massaguer


The progress in reconstruction of an in vitro three-dimensional skin model that accurately represents the complex human skin microenvironment depends on the advance of tissue engineering. In this way, the 3D bioprinting technique is an emerging technology that allows the precise, hierarchical and automated deposition of cells and biomaterials for the construction of mimetics with greater structural complexity, reproducibility and speed. Thus, bioprinted skin models provide a platform of high relevance for studies of skin pathophysiology, as well as supplying the need for a system to evaluate the safety and efficacy of cosmetics and medicines alternative to the animals use. Studies with bioprinted skins containing cell types beyond the classical combination of keratinocytes and fibroblasts, representing the dermal and epidermal layers are still limited, demonstrating that this is a field that is at the frontier of knowledge and represents a major technological challenge. Therefore, the objective of this research project is the reconstruction of a three-dimensional skin, containing in addition to the dermis and epidermal layers, the layer of hypodermis and all its fundamental cell types, using 3D bioprinting technology. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FERREIRA BRANQUINHO, MARYANA STEPHANY; BARROS SILVA, MAYSA BRAGA; CASTILHO, GABRIELA ANSANELO; CAVALCANTE, JACQUELINE; DE MORAES BARROS, SILVIA BERLANGA; CLARA, RENAN ORSATI; MARIA-ENGLER, SILVYA STUCHI; CAMPA, ANA. ynurenine inhibits melanogenesis in human melanocyte-keratinocyte co-cultures and in a reconstructed 3D skin mode. EXPERIMENTAL DERMATOLOGY, v. 31, n. 3, . (19/14527-7, 17/04926-6)
MALLAUPOMA CAMARENA, DENISSE ESTHER; ALCANTARA SEKIMOTO MATSUYAMA, LARISSA SATIKO; MARIA-ENGLER, SILVYA STUCHI; CATALANI, LUIZ HENRIQUE. Development of Epidermal Equivalent from Electrospun Synthetic Polymers for In Vitro Irritation/Corrosion Testing. NANOMATERIALS, v. 10, n. 12, . (11/21442-6, 18/13492-2, 17/04926-6, 19/14527-7)
MINI, C. A.; DREOSSI, S. A. C.; ABE, F. R.; MARIA-ENGLER, S. S.; OLIVEIRA, D. P.. Immortalized keratinocytes cells generates an effective model of Epidermal Human Equivalent for irritation and corrosion tests. TOXICOLOGY IN VITRO, v. 71, . (16/15660-4, 17/04926-6, 19/14527-7)

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