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Effects of cell-based therapy on autoimmune meningoencefalomielitis

Abstract

Inflammatory injuries of the central nervous system (CNS) are particularly disabling for both human and domestic animals. Multiple Sclerosis (MS) in humans and Meningoencephalomyelitis of Unknown Origin (MUO) in dogs are the most common neuroimmune diseases. The Experimental Autoimmune Encephalomyelitis (EAE) in mice, as animal model for MS, has contributed to the understanding of the pathophysiology of neuroimmune diseases, especially in the context of translational medicine for the development of new drugs. Due the limited regenerative capacity of the CNS, therapeutic potential of multipotent stromal cells (MSC) has recently been studied in several CNS pathological conditions, such as degenerative and chronic inflammatory conditions, as well as acute neuronal damage. Although gaps still exist in understanding the mechanisms of action of MSC, it is known that MSC can play an important role in neuroimmune diseases, due to their immunomodulatory, neurotrophic properties and capacity to induce angiogenesis, reduce inflammation, recruit resident progenitor cells and reduce fibrosis and can thus regenerate or provide support for the survival of damaged outer cells. In this context, our hypothesis is that MSC therapy in animals affected by neuroimmune diseases (EAE and MUO) have positive effects on the immunomodulation and neuroregenation process. Thus, we aimed to evaluate the safety and effectiveness of canine adipose tissue derived multipotent stromal cells (AT-MSCs) and canine placenta derived multipotent stromal cells (PMSCs) therapy in EAE and natural MUO. (AU)

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