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Effects of home-based exercise on aldosterone, ventricular mass and arterial stifness in hemodialysis

Grant number: 19/10413-7
Support type:Regular Research Grants
Duration: May 01, 2020 - April 30, 2023
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Luis Cuadrado Martin
Grantee:Luis Cuadrado Martin
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Assoc. researchers: Jonas Alves de Araujo Junior ; Pasqual Barretti ; Roberto Jorge da Silva Franco ; Silméia Garcia Zanati Bazan


Chronic kidney disease (CKD) is a serious public health problem. Patients with CKD have a high cardiovascular risk and the high concentration of Aldosterone (Aldo) contributes to this risk. The physical exercise in other pathological conditions decreased to Aldo, thus, could also decrease to Aldo in the DRC. Left ventricular hypertrophy (LVH) has a poor prognosis for these patients and its decrease is beneficial. Previous work in our group verified the effect of physical exercise on the reduction of left ventricular mass (LVM) in CKD. Since exercise on hemodialysis (HD) could decrease Aldo, which is associated with cardiac growth, the reduction of exercise-induced LVM could be mediated by the decrease in Aldo. Analogous reasoning, when exposed in relation to LVH, can be applied to arterial stiffness (RA). Thus, the beneficial effects of physical exercise could be mediated by Aldo's decrease in CKD. Objective: To verify the physical exercise effects in Aldo, MVE and RA in patients with CKD in HD. Materials and methods: controlled clinical trial, randomized, parallel, open and with blind observer. Participants will have CKD in HD older than 17 years and Plasma Aldo above 15 ng / dL. Volunteers will be randomized into two groups: intervention and control. The intervention will last 12 weeks, after that period the control group will be submitted to intervention and vice versa. Values of Aldo, central and peripheral blood pressure, RA and MVE will be evaluated. Two-Way ANOVA for repeated data and simple linear regression analysis will be applied to verify the association between Aldo and MVE variations. The level of significance will be 5%. (AU)

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