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Yellow fever vaccine efficacy in patients with surgical remove of the thymus after neonatal congenital heart disease repair

Grant number: 19/25240-0
Support type:Regular Research Grants
Duration: June 01, 2020 - May 31, 2021
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Paulo Henrique Manso
Grantee:Paulo Henrique Manso
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Assoc. researchers:Benedito Antônio Lopes da Fonseca ; Luiza Antunes de Castro Jorge ; Vitor Gonçalves Floriano

Abstract

Yellow fever is an endemical viral borne disease, prevented by vaccination. However, for its efficacy, the patient must be immunocompetent. Patients who were submitted to open heart surgery in the neonatal period usually have the thymus surgically removed. The objective of this project is to evaluate wheter these patients present an adequate response to yellow fever virus. (AU)