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Evaluation of annexin A1 protein immunomodulatory activity in cutaneous and placental lesions resulting from Diabetes Mellitus

Grant number: 19/19949-7
Support Opportunities:Regular Research Grants
Duration: July 01, 2020 - June 30, 2023
Field of knowledge:Biological Sciences - Morphology - Histology
Principal Investigator:Sonia Maria Oliani
Grantee:Sonia Maria Oliani
Host Institution: Instituto de Biociências, Letras e Ciências Exatas (IBILCE). Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. São José do Rio Preto , SP, Brazil
Associated researchers:Ana Paula Girol ; Cristiane Damas Gil ; Iracema de Mattos Paranhos Calderon ; Karin Vicente Greco ; Suchita Nadkarni

Abstract

Annexin A1 (ANXA1) is a 37 kDa protein that exhibits calcium and membrane phospholipid binding sites and is involved in the inhibition of glucocorticoid-induced eicosanoid and phospholipase A2 synthesis, which gives antiinflammatory properties to this protein. Several studies have shown the protective effect of ANXA1 on acute and chronic inflammatory processes in response to infection and autoimmune diseases. In addition to inflammatory events, the actions of ANXA1 have been poorly studied in tissue regeneration processes, especially in the regeneration and repair of damaged tissues and in wound healing. Further analysis of the various biological activities described for ANXA1, especially in the control of proliferation and apoptosis, and investigating the role of this protein in trophoblast biology and the modulation of markers related to the survival of these cells, is extremely important for understanding normal placental development and diseases such as Gestational Diabetes Mellitus (GDM). For these reasons, the proposed projects are related to the investigation of this protein through analyzes on experimental skin lesions and human placental pathophysiology to evaluate its therapeutic potential in the possible complications related to Diabetes Mellitus (DM). In the first proposal, in the in vivo model of a skin lesion, after standardizing the viable technique of an anionic gel with peptide AnxA12-26, it will be evaluated in relation to the healing properties of these lesions in type 1 DM (T1DM). The second proposal will identify the role of ANXA1 in placental cell survival and infer a potential mechanism (related to DNA damage and repair) that could relate ANXA1 to placental cell survival in GDM. In the proposed projects, different methodologies will be employed such as: AnxA12-26 anionic gel formulation, immunohistochemical reactions for inflammatory and molecular mediators (such as oxidative DNA damage and double DNA breakdown), Western blot, etc., involving strategies that will enable the detailed understanding of ANXA1 activity in the proposed aspects and its possible therapeutic applications. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANCHES, JOSE MARCOS; CORREIA-SILVA, REBECA D.; DUARTE, GUSTAVO H. B.; FERNANDES, ANNA MARIA A. P.; SANCHEZ-VINCES, SALVADOR; CARVALHO, PATRICIA O.; OLIANI, SONIA M.; BORTOLUCI, KARINA R.; MOREIRA, VANESSA; GIL, CRISTIANE D.. Role of Annexin A1 in NLRP3 Inflammasome Activation in Murine Neutrophils. CELLS, v. 10, n. 1, . (20/03565-2, 19/19949-7)
LUCCHI, DANILO B. M.; SASSO, GISELA R. S.; SENA, LETICIA S.; SANTOS, DIEGO D.; FRANCO, PAULO C.; LICE, IZABELLA; BORGES, FERNANDA T.; OLIANI, SONIA M.; GIL, CRISTIANE D.. The role of annexin A1-derived peptide Ac2-26 on liver and kidney injuries induced by cisplatin in rats. Life Sciences, v. 304, p. 10-pg., . (19/14331-5, 19/19949-7, 20/03565-2)
SENA, LETICIA S.; SASSO, GISELA R. S.; SANCHES, JOSE MARCOS; FRANCO, PAULO C.; AZEVEDO, MARISA F.; OLIANI, SONIA M.; GIL, CRISTIANE D.. Pharmacological treatment with annexin A1-derived peptide protects against cisplatin-induced hearing loss. Toxicology Letters, v. 363, p. 9-pg., . (19/19949-7, 20/03565-2)
DE SOUSA, STEFANIE OLIVEIRA; DOS SANTOS, MAYK RICARDO; TEIXEIRA, SAMUEL COTA; FERRO, ELOISA AMALIA VIEIRA; OLIANI, SONIA MARIA. ANNEXIN A1: Roles in Placenta, Cell Survival, and Nucleus. CELLS, v. 11, n. 13, p. 9-pg., . (19/19949-7)
GIROL, ANA PAULA; ZANON, CAROLINE DE FREITAS; CARUSO, ICARO PUTINHON; COSTA, SARA DE SOUZA; SOUZA, HELENA RIBEIRO; CORNELIO, MARINONIO LOPES; OLIANI, SONIA MARIA. Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis. CELLS, v. 10, n. 11, . (15/03359-5, 19/19949-7)
MORELI, JUSCIELE BROGIN; DOS SANTOS, MAYK RICARDO; PARANHOS CALDERON, IRACEMA DE MATTOS; HEBEDA, CRISTINA BICHELS; FARSKY, SANDRA HELENA POLISELLI; BEVILACQUA, ESTELA; OLIANI, SONIA MARIA. The Role of Annexin A1 in DNA Damage Response in Placental Cells: Impact on Gestational Diabetes Mellitus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 12, p. 15-pg., . (19/19949-7, 14/07328-4)
SANT, MONIELLE; AMANTINO, CAMILA F.; SILVA, RAFAEL A.; GIL, CRISTIANE D.; PRIMO, FERNANDO L.; GIROL, ANA P.; OLIANI, SONIA M.; V. GRECO, KARIN. Annexin A12-26 hydrogel improves healing properties in an experimental skin lesion after induction of type 1 diabetes. BIOMEDICINE & PHARMACOTHERAPY, v. 165, p. 12-pg., . (19/19949-7)
CARDOSO, LUANA PEREIRA; DE SOUSA, STEFANIE OLIVEIRA; GUSSON-ZANETONI, JULIANA PRADO; DE MELO MOREIRA SILVA, LAURA LUCIANA DE MELO MOREIRA; FRIGIERI, BARBARA MARIA; HENRIQUE, TIAGO; TAJARA, ELOIZA HELENA; OLIANI, SONIA MARIA; RODRIGUES-LISONI, FLAVIA CRISTINA. Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway. PHARMACEUTICALS, v. 16, n. 1, p. 21-pg., . (17/02100-3, 19/19949-7)
OLIVEIRA, MARCIA PEREIRA; PRATES, JANESLY; GIMENES, ALEXANDRE DANTAS; CORREA, SILVIA GRACIELA; OLIANI, SONIA MARIA. Annexin A1 Mimetic Peptide Ac2-26 Modulates the Function of Murine Colonic and Human Mast Cells. FRONTIERS IN IMMUNOLOGY, v. 12, . (19/19949-7)

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