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Food deprivation effects in kisspeptin neurons excitability

Grant number: 19/21707-1
Support type:Regular Research Grants
Duration: September 01, 2020 - August 31, 2022
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Renata Frazão
Grantee:Renata Frazão
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

It is well known that nutritional status affects directly the reproduction, since an adequate amount of energy is necessary for the onset of puberty, establishment of estral cyclicity and fertility. The regulation of food intake and energy balance are modulated by leptin, which acts mainly on the arcuate nucleus (ARH). Leptin modulates the activity of orexigenic neurons, neuropeptide Y and Agouti-related peptide, and anorexigenic neurons, pro-opiomelanocortin and Cocaine- and amphetamine-regulated transcript-expressing cells. Evidence suggests the interaction between kisspeptin neurons, the main activator of neurons that synthesize gonadotrophin releasing hormone, and neurons that regulate food intake. However, the mechanisms by which this interaction occurs are still not fully understood. In the present study we will use neuroanatomical and electrophysiological strategies additionally to genetically modified mice to evaluate whether the activity of kisspeptin neurons and consequently the reproductive system can be modulated by factors that alter food intake, such as fasting or caloric restriction. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DONATO, JR., JOSE; WASINSKI, FREDERICK; FURIGO, ISADORA C.; METZGER, MARTIN; FRAZAO, RENATA. Central Regulation of Metabolism by Growth Hormone. CELLS, v. 10, n. 1 JAN 2021. Web of Science Citations: 0.

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