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CNS metabolic control: the POMC neurons action on autonomic and ventilatory systems during exercise

Grant number: 18/05874-2
Support type:Research Grants - Young Investigators Grants
Duration: April 01, 2021 - March 31, 2026
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Mirian Bassi Solcia
Grantee:Mirian Bassi Solcia
Home Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Assoc. researchers:Carlos Cesar Crestani ; Eduardo Colombari

Abstract

The arcuate nucleus of hypothalamus (ARC) mediates the autonomic, respiratory and metabolic function. In the ARC, the hormone leptin act on a specifically group of cells called POMC neurons. Previous studies demonstrated that a disruption of this system (leptin-POMC-ARC) are associated with obesity and metabolic disease predicting cardiovascular and respiratory disorders as well a low quality of life due to sedentary. In this project we hypothesis that POMC-ARC neurons might be an essential mechanism to modulate cardiovascular and respiratory control not only on basal conditions but also during exercise. Therefore, the aim of the present study is to investigate the role of POMC-ARC signaling pathway on cardiovascular, respiratory, metabolic and thermoregulatory function during exercise. There will be evaluated the mean arterial pressure, heart rate, lung ventilation, metabolic index and body temperature in a Pomc-cre mice with blockage of POMC-ARC neurons during exercise (treadmill running). The results of this study can help the scientific community and the lay people to understanding that poor diet and sedentary lifestyle hamper an important neural mechanism (POMC-ARC) that may limit physical activity due to cardiorespiratory disruption. (AU)