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Effects of intersterified fat on the intestinal permeability of healthy and obese animals

Abstract

Obesity represents a serious public health problem and, because it's a chronic multifactorial disease, predisposes the body to a series of diseases and it is related to increased mortality rate. Also considered a condition where there is activation of low-grade systemic inflammation, obesity is directly related to increased levels of proinflammatory markers, changes in intestinal permeability and aggravation of inflammatory bowel processes. Dietary patterns, especially high-fat diets, appear to negatively influence the control of intestinal permeability, favoring increased bacterial translocation, and therefore have been frequently studied. In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat rich in trans isomers and has been used in processed foods. There is evidence that IF has important metabolic effects such as body mass gain and glucose intolerance as well as lipid profile and development of atherosclerosis. Recent data not yet published by the group showed that a diet supplemented with interesterified palm oil is able to modulate the expression of proinflammatory cytokines IL-1² and IL-6 in metabolically important tissues such as mouse liver and adipose tissue. However, the mechanisms involved in the metabolic and immunomodulatory effects of IF are not completely understood. Thus, the aim of this study is to evaluate the effect of interesterified fat intake on the intestinal mucosa of healthy or obese male Swiss mice, determining its effects on permeability, as well as its action on intestinal mucosal immunomodulation. This is intended to increase the understanding of the metabolic effect of IF intake, as well as to subsidize public policies for a possible regulation of the use of this fat structured by the food industry. (AU)

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VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)