Relationship between intracellular ATP dynamics and modulation of cytosolic calcium concentration in the neuron

• Grant number: 19/27245-0
• Support Opportunities: Regular Research Grants
• Start date: November 01, 2020
• End date: October 31, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Fernando Augusto de Oliveira Ribeiro
• Grantee: Fernando Augusto de Oliveira Ribeiro
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated researchers: Manoel de Arcisio Miranda Filho

Abstract

Calcium (Ca2+) is a fundamental ion for cellular homeostasis, serving as a signaling molecule for numerous intracellular events in the neuron. At rest its concentration is around nanomolar and during neuronal activity this concentration can reach millimolar values. The rise and decay of intracellular Ca2+ occurs mainly by specific mechanisms in cell membranes. Among these mechanisms, there are ATP dependent structures for cytosolic Ca2+ removal. Intracellular ATP is generated through biochemical processes by breaking down glucose from the extracellular medium, or lactate, carried by astrocytes to neurons. In this project we intend to verify how intracellular biochemical pathways and lactate sent by astrocytes affect neuronal Ca2+ dynamics and its ATP-dependent intracellular removal mechanisms. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

XAVIER DE LIMA, MIGUEL ANTONIO; BALDO, MARCUS VINICIUS C.; OLIVEIRA, FERNANDO A.; CANTERAS, NEWTON SABINO. The anterior cingulate cortex and its role in controlling contextual fear memory to predatory threats. eLIFE, v. 11, JAN 5 2022. (14/05432-9, 16/10389-0, 19/27245-0)