Deciphering immuno biomarkers of HTLV infection and HIV/HTLV coinfection to improve patient treatments

• Grant number: 20/05758-2
• Support Opportunities: Regular Research Grants
• Start date: December 01, 2020
• End date: November 30, 2022
• Field of knowledge: Biological Sciences - Immunology - Applied Immunology
• Agreement: Université de Lyon (UDL)
• Principal Investigator: Jorge Simao do Rosario Casseb
• Grantee: Jorge Simao do Rosario Casseb
• Principal researcher abroad: Dutartre Hélène
• Institution abroad: Universidad de Lleida (UdL), Spain
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 22/02068-0 - Deciphering immunobiomarkers of HTLV infection and HIV/HTLV coinfection to improve patient treatments, BP.TT

Abstract

The HTLV-1 human oncogenic retrovirus infects 10-20 million worldwide, with more than 1 million carriers living in Brazil [1]. Five to 10 percent of infected individuals will develop an HTLV-1 associated disease: Adult T cell Leukemia (ATL), an aggressive lymphoproliferation of CD4+ T cells of poor prognosis (mean survival time of 6 months in the acute form), or HTLV-1 associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), a chronic neuro-degenerative disease. Several mechanisms lead to HTLV-1 associated disease progression, the first being the oncogenic properties of Tax and HBZ viral proteins. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TEIXEIRA, SANDY VIEIRA; PRATES, GABRIELA; FONSECA, LUIZ AUGUSTO MARCONDES; CASSEB, JORGE. Can Persistent Infections with Hepatitis B Virus, Hepatitis C Virus, Human Immunodeficiency Virus, and Human T Lymphotropic Virus Type 1 Be Eradicated?. AIDS Research and Human Retroviruses, v. 40, n. 3, p. 7-pg., 2023-08-22. (21/12316-9, 20/05758-2)

MARCUSSO, ROSA MARIA DO NASCIMENTO; ASSONE, TATIANE; HAZIOT, MICHEL E.; SMID, JERUSA; FOLGOSI, VICTOR A.; ROSADAS, CAROLINA; CASSEB, JORGE; DE OLIVEIRA, AUGUSTO C. PENALVA. HTLV-1-Associated Myelopathy (HAM) Incidence in Asymptomatic Carriers and Intermediate Syndrome (IS) Patients. PATHOGENS, v. 13, n. 5, p. 8-pg., 2024-05-01. (21/12316-9, 14/22827-7, 20/05758-2)