Neuroprotective effect of lithium in participants at risk for Alzheimer's disease

• Grant number: 19/08507-3
• Support Opportunities: Regular Research Grants
• Start date: September 01, 2019
• End date: September 30, 2022
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Agreement: Consortium of Alberta, Laval, Dalhousie and Ottawa (CALDO)
• Mobility Program: SPRINT - Projetos de pesquisa - Mobilidade
• Principal Investigator: Orestes Vicente Forlenza
• Grantee: Orestes Vicente Forlenza
• Principal researcher abroad: Tomas Hajek
• Institution abroad: Dalhousie University , Canada
• Principal researcher abroad: Tomas Hajek
• Institution abroad: Dalhousie University , Canada
• Principal researcher abroad: Tomas Hajek
• Institution abroad: Dalhousie University , Canada
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo

Abstract

The search for drugs with neuroprotective effects and disease-modifying properties for Alzheimer's disease (AD) is an area of major interest, since the incidence and prevalence of this disorder are predicted to rise exponentially. Thus, new interventions that prevent or delay the emergence of AD would have an enormous impact on clinical practice and public health, particularly in view of the recent failure of most trials with anti-amyloid immunotherapy. This project would facilitate collaboration between 2 groups, with overlapping interests and complementary expertise. Dr. Forlenza`s group in São Paulo has approached the neuroprotective effects of Li by running treatment trials in aMCI. Dr. Hajek`s team in Halifax has investigated the effects of Li on brain structure in bipolar disorders. This proposal intends to research a highly interesting neuroprotective treatment (Li), which is supported by an extensive body of evidence, in a vulnerable population (people at risk for AD), with the ultimate goal of preventing or delaying the onset of dementia. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

DAMIANO, RODOLFO FURLAN; LOUREIRO, JULIA CUNHA; PAIS, MARCOS VASCONCELOS; PEREIRA, RODRIGO FURTADO; CORRADI, MARINA DE MENEZES; DI SANTI, TALITA; BEZERRA, GUSTAVO ANTONIO MARCOLONGO; RADANOVIC, MARCIA; TALIB, LEDA LEME; FORLENZA, ORESTES VICENTE. Revisiting global cognitive and functional state 13 years after a clinical trial of lithium for mild cognitive impairment. Revista Brasileira de Psiquiatria, v. 45, n. 1, p. 4-pg., 2023-01-01. (19/08507-3, 14/50873-3)

FORLENZA, ORESTES, V; HAJEK, TOMAS; ALMEIDA, OSVALDO P.; BEUNDERS, ALEXANDRA J. M.; BLUMBERG, HILARY P.; BRIGGS, FARREN B. S.; DE-PAULA, VANESSA J. R.; DOLS, ANNEMIEK; EYLER, LISA T.; FORESTER, BRENT P.; et al. Demographic and clinical characteristics of lithium-treated older adults with bipolar disorder. ACTA PSYCHIATRICA SCANDINAVICA, v. 146, n. 5, p. 14-pg., 2022-07-26. (19/08507-3, 14/50873-3)

FORLENZA, ORESTES V.; XU, NI; CHEN, PEIJUN; REJ, SOHAM; GILDENGERS, ARIEL G.; HAJEK, TOMAS; SAJATOVIC, MARTHA. Demographic and Clinical Characteristics of Lithium-Treated Older Adults With Bipolar Disorder: A Replication Study From the Global Aging and Geriatric Experiments in Bipolar Disorder (GAGE-BD) Project. ACTA PSYCHIATRICA SCANDINAVICA, v. N/A, p. 4-pg., 2025-07-10. (14/50873-3, 14/50873-3, 19/08507-3)