Research Grants 19/10228-5 - Biomateriais, Engenharia tecidual - BV FAPESP
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Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system

Grant number: 19/10228-5
Support Opportunities:Research Projects - Thematic Grants
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Ana Claudia Muniz Renno
Grantee:Ana Claudia Muniz Renno
Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil
Associated researchers:Alessandra Mussi Ribeiro ; Gustavo Rafael Mazzaron Barcelos ; Márcio Reis Custódio ; Renata Neves Granito ; Veerle Bloemen ; Wagner Vilegas
Associated scholarship(s):24/18304-0 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of thea osteoarticular systema, BP.TT
24/17974-2 - In vivo studies of scaffolds composed of biosilica extracted from the sponge Dragmacidon reticulatum, or by the combination of biosilica and spongine extracted from the sponge Aplysina fulva in the process of bone repair in experimental models in osteopor, BP.TT
24/03709-5 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.JC
+ associated scholarships 23/02837-7 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.TT
22/04433-8 - Manufacture of 3D marine sponge from biosilica scaffolds for use in bone tissue engineering and their evaluation of biological effects in vitro, BP.MS
22/13515-8 - Terpenes: evaluation of the anti-inflammatory effects of bioactives in cell culture, BP.DD
21/13056-0 - 3D printing of collagen skin dressings from marine sponges and fish skin: a comparative study for application in skin wounds treatment, BP.DR
22/04991-0 - 3D printing: Characterization and in vitro studies of skin dressings manufactured from collagen from fish skin and marine sponges, BP.MS
22/04816-4 - Hyaluronic acid enriched with sea sponge anti-inflammatory compounds as a therapeutic intervention for osteoarthritis: evaluation in in vitro experimental models, BP.MS
22/05410-1 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.TT
21/14037-0 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.IC
21/11659-0 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.TT
21/11845-8 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.DD
21/02974-9 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.PD
21/05622-6 - Interdisciplinar net for the development of biotechnological products from marine origin for use in human health: pathological complication of the osteoarticular system, BP.TT
21/02975-5 - Toxicity and genotoxicity of biomaterials of marine origin in human health, BP.TT - associated scholarships

Abstract

Nowadays, a significant increase in the incidence of degenerative diseases has been observed including Osteoporosis and Osteoarthritis. In this context, it is necessary to develop treatments able of treating the symptoms related to these diseases. The marine biodiversity is an extremely rich environment for extracting bioactive compounds to be used as raw materials for manufacturing drugs, medicines and biomaterials. One of the most promising marine species is the sponge, with its composition and structure, with anti-inflammatory and anti-cancer potential. Also, they have an organic and an inorganic to be used as biomaterials. In order to investigate the potential of bioactive compounds of marine sponges, this proposal has the objective of characterizing and evaluating the biological effects of anti-inflammatory elements and scaffolds composed by biosilica and biosilica and spongin in in vitro and in vivo studies. For the characterization tests, scanning electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy and degradation and pH tests will be performed. Also, in vitro studies will be made to evaluate the anti-inflammatory potential of terpenes in macrophages and chondrocytes. The biological effects of terpenes will be evaluated using an experimental model of Osteoarthritis in rats. Moreover, biosilica and spongin scaffolds will be tested in vitro studies (osteoblasts) and in vivo (Osteoporosis animal model). After the respective experimental times, the animals will undergo euthanasia and the samples will be processed for microtomography, histological, histomoformetric and biomechanical analyzes. Through these analyzes the biological interaction of the proposed treatments with the biological tissues will be evaluated. This proposal will enable the development of innovative, more effective and safe treatments to accelerate the process of tissue repair and treatment of joint degeneration and fracture consolidation, resulting in economic and social benefits for the Brazilian population, reducing costs related to treatment, hospitalizations and improving the quality of life of the affected individuals. Another great advantage is that the biomaterials that are being produced by our group are manufactured from domestic raw material and also with national technology, it is estimated that the final price of the products is much lower compared to the products already available in the market. This fact is one of the main motivations of our group, that is, to develop highly effective products with the lowest final price, which will allow access to these treatments for a greater number of people. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SANTOS, CINTIA P. G.; PRADO, JOAO P. S.; FERNANDES, KELLY R. R.; KIDO, HUELITON W. W.; DORILEO, BIANCA P. P.; PARISI, JULIA R. R.; SILVA, JONAS A. A.; CRUZ, MATHEUS A. A.; CUSTODIO, MARCIO R.; RENNO, ANA C. M.; et al. Different Species of Marine Sponges Diverge in Osteogenic Potential When Therapeutically Applied as Natural Scaffolds for Bone Regeneration in Rats. JOURNAL OF FUNCTIONAL BIOMATERIALS, v. 14, n. 3, p. 19-pg., . (19/10228-5, 21/04957-4)
SOUZA-SILVA, LAIS CAROLINE; MARTIGNAGO, CINTIA CRISTINA SANTI; MOTTA, HOMERO GARCIA; BONIFACIO, MIRIAN; AVANZI, INGRID REGINA; ASSIS, LIVIA; RIBEIRO, DANIEL ARAKI; PARISI, JULIA RISSO; RENNO, ANA CLAUDIA. A Review of Cartilage Defect Treatments Using Chitosan Hydrogels in Experimental Animal Models. CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v. 25, n. 8, p. 15-pg., . (19/10228-5, 21/02974-9)
AVANZI, INGRID REGINA; PARISI, JULIA RISSO; SOUZA, AMANDA; CRUZ, MATHEUS ALMEIDA; SANTI MARTIGNAGO, CINTIA CRISTINA; RIBEIRO, DANIEL ARAKI; CAVALCANTE BRAGA, ANNA RAFAELA; RENNO, ANA CLAUDIA. 3D-printed hydroxyapatite scaffolds for bone tissue engineering: A systematic review in experimental animal studies. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 111, n. 1, p. 17-pg., . (19/10228-5)
MARTIGNAGO, CINTIA CRISTINA SANTI; SOARES-SILVA, BEATRIZ; PARISI, JULIA RISSO; SILVA, LAIS CAROLINE SOUZA E; GRANITO, RENATA NEVES; RIBEIRO, ALESSANDRA MUSSI; RENNO, ANA CLAUDIA MUNIZ; DE SOUSA, LORENA RAMOS FREITAS; AGUIAR, ANNA CAROLINE CAMPOS. Terpenes extracted from marine sponges with antioxidant activity: a systematic review. NATURAL PRODUCTS AND BIOPROSPECTING, v. 13, n. 1, p. 12-pg., . (19/10228-5, 19/19708-0)

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