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Evaluation and inhibition of endoplasmic reticulum stress in the intestinal mucosa of Crohn's disease patients

Grant number: 20/04407-1
Support type:Regular Research Grants
Duration: February 01, 2021 - January 31, 2023
Field of knowledge:Biological Sciences - Immunology - Immunogenetics
Principal researcher:Raquel Franco Leal
Grantee:Raquel Franco Leal
Home Institution: Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Assoc. researchers:Licio Augusto Velloso ; Marciane Milanski Ferreira ; Maria de Lourdes Setsuko Ayrizono

Abstract

Inflammatory bowel diseases (IBD) are characterized by chronic intestinal inflammation and represent a relevant health problem with increasing incidence in recent decades in Brazil. Crohn's disease (CD) is one of the two main common form of IBD, which mainly affects young adults where granulomatous transmural inflammation of the mucosa is observed throughout the gastrointestinal tract, but mainly in the terminal ileum and colon. CD is characterized by periods of remission and relapse accompanied by diarrhea, abdominal pain, weight loss, malnutrition, often leading to intestinal lumen stenosis associated with the formation of multiple fistulas. CD is a disease of multifactorial origin that affects genetically susceptible individuals, in which an inadequate immune response results from complex environmental, microbial and innate adaptive immune system interactions. Recent genome wide association (GWAS) and meta-analysis studies have shown that endoplasmic reticulum (ER) stress possibly correlates with the pathogenesis of CD. Thus, the objective of this project will be to investigate the occurrence of ER stress in the intestinal mucosa of CD patients. To do that, intestinal mucosa biopsies from 15 CD patients and 10 non-IBD control patients (CTR) will be subjected to cell culture for evaluation of ER stress and its potential in vitro blockade with chemical chaperone. Modulation of ER stress-related transcripts in intestinal biopsies of CD patients and controls will be evaluated, as well as proteins related to the inflammatory process in the cell culture supernatant. This study may bring major scientific advances contributing to the discovery of the pathophysiological mechanisms of CD, and to identify potential therapeutic targets aimed at healing the intestinal mucosa. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Una dieta rica en fibras puede cumplir un papel en el control de la inflamación asociada al COVID-19  
High-fiber diet may play a role in controlling the inflammation associated with COVID-19 
Articles published in other media outlets (58 total):
More itemsLess items
Al Día (Cuba): Una dieta rica en fibras puede ayudar a controlar la inflamación asociada al COVID-19 (06/May/2021)
Santegra (Rússia): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (07/Apr/2021)
Catalunya Vanguardista (Espanha): Una dieta rica en fibras contra la inflamación asociada al COVID-19 (06/Apr/2021)
My Pharmacy News: Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells (03/Apr/2021)
Archyde: Do High Fiber Diets Help Reduce Inflammation? – healing practice (03/Apr/2021)
Health910: High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (03/Apr/2021)
Bionity (Estônia): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (01/Apr/2021)
Heilpraxisnet.de (Alemanha): COVID-19: Hilft eine ballaststoffreiche Ernährung die Entzündungen zu reduzieren? (01/Apr/2021)
Environmental News Network (EUA): High-Fiber Diet May Play a Role in Controlling the Inflammation Associated With COVID-19 (31/Mar/2021)
Medical Xpress (Reino Unido): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (31/Mar/2021)
Panorama Farmacêutico: Dieta rica em fibras pode ter papel no controle de inflamação associada à Covid-19 (31/Mar/2021)
ClinicalNews (EUA): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (31/Mar/2021)
MDLinx (EUA): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (31/Mar/2021)
Technologie Média: COVID-19 : un régime riche en fibres contre l’inflammation (31/Mar/2021)
Globe Health News: Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells (31/Mar/2021)
Verietyinfo.com: Molecules derived from microbiota do not alter the entry or replication of SARS-CoV-2 in intestinal cells (31/Mar/2021)
The Health News Express: High-fiber weight loss program might play a task in controlling the irritation related to COVID-19 (31/Mar/2021)
The Gary Null Show - Podbean (EUA): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (31/Mar/2021)
News Medical (Austrália): Microbiota-derived molecules do not change the entry or replication of SARS-CoV-2 in intestinal cells (30/Mar/2021)
Bioengineer (Reino Unido): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
Science Codex: High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
Scienmag Science Magazine (Reino Unido): High-Fiber Diet May Play A Role In Controlling The Inflammation Associated With COVID-19 (30/Mar/2021)
7thSpace: High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
Healthcare Hygiene Magazine (EUA): High-Fiber Diet May Play Role in Controlling the Inflammation Associated With COVID-19 (30/Mar/2021)
A Closer Look (EUA): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
The Uncover Reality (Índia): High-fiber Diet May Play A Role in Controlling The Inflammation Associated With COVID-19 (Food) (30/Mar/2021)
Biotech Asia News (Índia): High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
iHealthyZone: High-fiber diet may play a role in controlling the inflammation associated with COVID-19 (30/Mar/2021)
Today's Practitioner (EUA): Lab Study: High-fiber Short Chain Fatty Acids May Control COVID-19 Related Gut Tissue Inflammation (30/Mar/2021)
Cofemac: Dieta rica em fibras pode ajudar pacientes com covid (28/Mar/2021)
Portal Correio: Dieta rica em fibras pode ter papel no controle de inflamação associada à Covid-19 (28/Mar/2021)
Rede SIC - Sistema Independente de Comunicação: Dieta rica em fibras pode ter papel no controle da inflamação associada à Covid-19 (17/Mar/2021)
A Cidade On (Campinas, SP): Estudo da Unicamp indica dieta para controle de inflamação associada à covid (09/Mar/2021)
Jornal do Sudoeste : Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (09/Mar/2021)
Folha do ABC online: Dieta rica em fibras pode controlar inflamação associada à Covid (08/Mar/2021)
Blog Jornal da Mulher: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (08/Mar/2021)
A Cidade On (São Carlos, SP): Dieta rica em fibras pode ter papel no controle da inflamação associada à Covid-19 (08/Mar/2021)
Saense: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (08/Mar/2021)
O Estado do Maranhão online: Dieta rica em fibras pode ter papel no controle da inflamação associada à Covid-19 (07/Mar/2021)
Aparecidanet: Dieta rica em fibras pode ajudar no controle da inflamação associada à COVID-19 (07/Mar/2021)
Plantão News (MT): Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (06/Mar/2021)
Meio Norte online (Piauí): Dieta rica em fibras pode ter papel no controle da inflamação da Covid (05/Mar/2021)
Jornal da Unicamp online: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
UNICAMP - Universidade Estadual de Campinas: Dieta rica em fibras pode ter papel no controle na inflamação associada à Covid-19 (05/Mar/2021)
A Crítica (MS) online: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Paranashop: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Diário da Saúde: Dieta rica em fibras ajuda a controlar inflamação da covid-19 (05/Mar/2021)
Investe São Paulo: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Espaço Ecológico no Ar: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Revista Amazônia: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Galileu online: Fibras podem ajudar a controlar inflamação intestinal ligada à Covid-19 (05/Mar/2021)
SB 24 horas: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Saber Atualizado: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Portal da Enfermagem: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Refugo: Fibras podem ajudar a controlar inflamação intestinal ligada à Covid-19 (05/Mar/2021)
Quimiweb: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)
Doutor Jairo Bouer: Covid-19: dieta rica em fibras talvez seja útil contra inflamação (05/Mar/2021)
Tubão: Dieta rica em fibras pode ter papel no controle da inflamação associada à COVID-19 (05/Mar/2021)