Study of the humoral immune response in recurrent infections by Plasmodium vivax in pregnant women from Amazon region

• Grant number: 20/06747-4
• Support Opportunities: Regular Research Grants
• Start date: April 01, 2021
• End date: March 31, 2023
• Field of knowledge: Biological Sciences - Parasitology - Protozoology of Parasites
• Principal Investigator: Cláudio Romero Farias Marinho
• Grantee: Cláudio Romero Farias Marinho
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• City of the host institution: São Paulo
• Associated researchers: Gerhard Wunderlich ; Lígia Antunes Gonçalves ; Paulo Afonso Nogueira ; Rodrigo Medeiros Martorano ; Sabrina Epiphanio ; Susana Gomes Campino ; Taane Clark

Abstract

Malaria in pregnancy is characterized by the presence of Plasmodium spp. in the peripheral blood or placenta, being one of the main causes of mortality in tropical regions, which causes maternal anemia, abortion, intrauterine growth restriction, preterm delivery and low birth weight. Plasmodium (P.) vivax is the dominant malaria species outside the African continent, accounting for about 40% of total malaria cases worldwide. In Brazil, the species with the highest prevalence is also P. vivax, and despite the significant reduction in numbers in recent years, more than 170,000 cases of this parasite are still reported annually. Due to high prevalence and the possible association with major complications during pregnancy, this project aims to study the profile of the humoral immune response by identifying the impact of multiple P. vivax infections during pregnancy. Knowledge of the mechanisms involved in the immunopathogenesis of infection during pregnancy will make an important contribution not only to the understanding of the immunobiology of the disease, but also in opening new paths of study that may result in a positive prognosis for both, mother and child. (AU)

Scientific publications

(15)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

IBRAHIM, AMY; MANKO, EMILIA; DOMBROWSKI, JAMILLE G.; CAMPOS, MONICA; BENAVENTE, ERNEST DIEZ; NOLDER, DEBBIE; SUTHERLAND, COLIN J.; NOSTEN, FRANCOIS; FERNANDEZ, DIANA; VELEZ-TOBON, GABRIEL; et al. Population-based genomic study of Plasmodium vivax malaria in seven Brazilian states and across South America. LANCET REGIONAL HEALTH-AMERICAS, v. 18, p. 21-pg., 2023-02-01. (20/06747-4, 16/13465-0, 19/12068-5)

HOLM, ANNA ENGELL; GOMES, LAURA CORDEIRO; LIMA, KARINE O.; WEGENER, ALMA; MATOS, LUAN O.; VIEIRA, ISABELLE V. M.; KAAGAARD, MOLLY D.; PAREEK, MANAN; DE SOUZA, RODRIGO MEDEIROS; FARIAS MARINHO, CLAUDIO ROMERO; et al. Tropical diseases and risk of hypertension in the Amazon Basin: a cross-sectional study. JOURNAL OF HUMAN HYPERTENSION, NOV 2021. (20/06747-4)

SANTIAGO, VERONICA FEIJOLI; DOMBROWSKI, JAMILLE GREGORIO; KAWAHARA, REBECA; ROSA-FERNANDES, LIVIA; MULE, SIMON NGAO; MURILLO, OSCAR; SANTANA, THAIS VIGGIANI; PACCINI COUTINHO, JOAO VICTOR; MACEDO-DA-SILVA, JANAINA; LAZARI, LUCAS CARDOSO; et al. Complement System Activation Is a Plasma Biomarker Signature during Malaria in Pregnancy. GENES, v. 14, n. 8, p. 20-pg., 2023-08-01. (21/14751-4, 18/15549-1, 20/06747-4, 20/04923-0, 17/04032-5, 21/00140-3, 19/12068-5, 18/20468-0)

GOMES, VINICIUS DE MORAIS; SANTOS, DEIVID MARTINS; MACEDO-DA-SILVA, JANAINA; LAZARI, LUCAS C.; MACHADO, RAFAEL RAHAL GUARAGNA; DOS SANTOS, ANCELY FERREIRA; ARAUJO, DANIELLE BASTOS; COUTINHO, JOAO VITOR PACCINI; ARINI, GABRIEL SANTOS; ANGELI, CLAUDIA B.; et al. P.1 and P.2 SARS-CoV-2 Brazilian variants activate the unfolded protein response with a time and pathway specificity. JOURNAL OF PROTEOMICS, v. 315, p. 17-pg., 2025-02-21. (20/06747-4, 16/04676-7, 15/26722-8, 19/09517-2, 22/13150-0, 21/14179-9, 20/06409-1, 18/15549-1, 18/07142-9, 18/18257-1, 17/24769-2, 16/20045-7, 20/04923-0, 21/00140-3)

WEGENER, ALMA; KAAGAARD, MOLLY D.; GOMES, LAURA CORDEIRO; HOLM, ANNA ENGELL; MATOS, LUAN O.; LIMA, KARINE O.; VIEIRA, ISABELLE V. M.; DE SOUZA, RODRIGO MEDEIROS; OLSEN, FLEMMING JAVIER; FARIAS MARINHO, CLAUDIO ROMERO; et al. Reference values for left ventricular dimensions, systolic and diastolic function: a study from the Amazon Basin of Brazil. INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING, NOV 2021. (20/06747-4)

PANDYA, YASH; MARTA, ALEXANDER; BARATEIRO, ANDRE; BANDEIRA, CARLA LETICIA; DOMBROWSKI, JAMILLE GREGORIO; COSTA, JOAO; FARIAS MARINHO, CLAUDIO ROMERO; PENHA-GONCALVES, CARLOS. TLR4-Endothelin Axis Controls Syncytiotrophoblast Motility and Confers Fetal Protection in Placental Malaria. Infection and Immunity, v. 89, n. 8, AUG 2021. (19/12068-5, 16/07030-0, 12/04755-3, 14/09964-5, 17/03939-7, 20/06747-4)

DOMBROWSKI, JAMILLE GREGORIO; BARATEIRO, ANDRE; MACHADO PEIXOTO, ERIKA PAULA; CLAUDIO DA SILVA BARROS, ANDRE BOLER; DE SOUZA, RODRIGO MEDEIROS; CLARK, TAANE GREGORY; CAMPINO, SUSANA; WRENGER, CARSTEN; WUNDERLICH, GERHARD; PALMISANO, GIUSEPPE; et al. Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon. PLoS Neglected Tropical Diseases, v. 15, n. 4, APR 2021. (17/03966-4, 17/03939-7, 18/18257-1, 19/12068-5, 15/26722-8, 17/24267-7, 20/06747-4, 18/20468-0, 20/04923-0, 18/15549-1, 17/05782-8)

KAAGAARD, MOLLY D.; MATOS, LUAN O.; HOLM, ANNA ENGELL; GOMES, LAURA CORDEIRO; WEGENER, ALMA; LIMA, KARINE O.; VIEIRA, ISABELLE V. M.; DE SOUZA, RODRIGO MEDEIROS; MARINHO, CLAUDIO ROMERO FARIAS; HVIID, LARS; et al. requency of Electrocardiographic Alterations and Pericardial Effusion in Patients With Uncomplicated Malari. AMERICAN JOURNAL OF CARDIOLOGY, v. 165, p. 116-123, FEB 15 2022. (20/06747-4)

SERCUNDES, MICHELLE K.; ORTOLAN, LUANA S.; JULIO, VIVIANE DA SILVA; BELLA, LEONARDO M.; QUIRINO, THATYANE DE CASTRO; DEBONE, DANIELA; CARNEIRO-RAMOS, MARCELA S.; CHRISTOFFOLETE, MARCELO A.; MARTINS, JOILSON O.; D'IMPERIO LIMA, MARIA REGINA; et al. lockade of caspase cascade overcomes malaria-associated acute respiratory distress syndrome in mic. CELL DEATH & DISEASE, v. 13, n. 2, FEB 10 2022. (20/03163-1, 13/20718-3, 15/06106-0, 20/06747-4, 20/03175-0)

WEGENER, ALMA; LIMA, KARINE O.; HOLM, ANNA E.; GOMES, LAURA C.; MATOS, LUAN O.; VIEIRA, ISABELLE V. M.; SOUZA, RODRIGO MEDEIROS; FARIAS MARINHO, CLAUDIO ROMERO; VESTERGAARD, LASSE S.; BIERING-SORENSEN, TOR; et al. Cardiopulmonary alterations by ultrasound in a patient with uncomplicated mixed malaria infection: a case report from the Amazon Basin. Malaria Journal, v. 20, n. 1, JUL 28 2021. (20/06747-4)

HOLM, ANNA ENGELL; GOMES, LAURA CORDEIRO; WEGENER, ALMA; LIMA, KARINE O.; MATOS, LUAN O.; VIEIRA, ISABELLE V. M.; KAAGAARD, MOLLY D.; PAREEK, MANAN; DE SOUZA, RODRIGO MEDEIROS; FARIAS MARINHO, CLAUDIO ROMERO; et al. Is self-rated health associated with cardiovascular risk factors and disease in a low-income setting? A cross-sectional study from the Amazon Basin of Brazil. BMJ OPEN, v. 12, n. 8, p. 9-pg., 2022-08-01. (20/06747-4)

SILVA-SANTOS, YASMIN; PAGNI, ROBERTA LIBERATO; GAMON, THAIS HELENA MARTINS; DE AZEVEDO, MARCELA SANTIAGO PACHECO; BIELAVSKY, MONICA; DARIDO, MARIA LAURA GOUSSAIN; DE OLIVEIRA, DANIELLE BRUNA LEAL; DE SOUZA, EDMARCIA ELISA; WRENGER, CARSTEN; DURIGON, EDSON LUIZ; et al. Lisinopril increases lung ACE2 levels and SARS-CoV-2 viral load and decreases inflammation but not disease severity in experimental COVID-19. FRONTIERS IN PHARMACOLOGY, v. 15, p. 14-pg., 2024-07-12. (20/06409-1, 15/26722-8, 23/05478-8, 20/06747-4, 22/13150-0, 20/12277-0)

NGWANA-JOSEPH, GABRIELLE C.; PHELAN, JODY E.; MANKO, EMILIA; DOMBROWSKI, JAMILLE G.; SANTOS, SIMONE DA SILVA; SUAREZ-MUTIS, MARTHA; VELEZ-TOBON, GABRIEL; TOBON CASTANO, ALBERTO; MACHADO, RICARDO LUIZ DANTAS; MARINHO, CLAUDIO R. F.; et al. Genomic analysis of global Plasmodium vivax populations reveals insights into the evolution of drug resistance. NATURE COMMUNICATIONS, v. 15, n. 1, p. 13-pg., 2024-12-30. (19/12068-5, 20/06747-4, 22/02771-3, 22/13150-0)

DE SOUZA, RODRIGO MEDEIROS; DOS SANTOS, MARIA INES; GOMES, LAURA CORDEIRO; DE MELO, BRUNA BEATRIZ PEDROZA; SEPAROVIC, ERIKA PAULA MACHADO; MURILLO, OSCAR; WUNDERLICH, GERHARD; CLARK, TAANE GREGORY; CAMPINO, SUSANA; EPIPHANIO, SABRINA; et al. Association of the humoral immune response with the inflammatory profile in Plasmodium vivax infections in pregnant women. PLoS Neglected Tropical Diseases, v. 18, n. 11, p. 15-pg., 2024-11-01. (20/03163-1, 20/06747-4, 21/13950-3, 21/07170-5, 19/12068-5, 22/13150-0)

ROSA-FERNANDES, LIVIA; SANTIAGO, VERONICA FEIJOLI; SILVA-SANTOS, YASMIN DA; LOPES, TISSIANE TAROSSO; PEIXOTO, ERIKA PAULA MACHADO; RODRIGUES, STEFANI APARECIDA MINCHIO; MARINHO, CLAUDIO ROMERO FARIAS; PALMISANO, GIUSEPPE; EPIPHANIO, SABRINA. Serum Proteomics of Experimental Malaria-Associated ARDS Reveals a Regulation of Acute-Phase Response Proteins. JOURNAL OF IMMUNOLOGY RESEARCH, v. 2025, n. 1, p. 13-pg., 2025-01-01. (20/03163-1, 18/15549-1, 22/08582-8, 20/04923-0, 20/06747-4, 23/05478-8, 22/13150-0, 18/20468-0)