Multi-user equipment approved in grant 2017/15850-0: Synergy-S

• Grant number: 21/02522-0
• Support Opportunities: Multi-user Equipment Program
• Duration: May 01, 2021 - April 30, 2028
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Convênio/Acordo: CNPq - Pronex
• Principal Investigator: Eduardo Ernesto Castellano
• Grantee: Eduardo Ernesto Castellano
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Pesquisadores principais: Alzir Azevedo Batista ; Javier Alcides Ellena
• Associated researchers: Denise Crispim Tavares Barbosa ; Diogo Rodrigo de Magalhães Moreira ; Fernando Rogério Pavan ; Fillipe Vieira Rocha ; Gustavo von Poelhsitz ; Marcelo Barbosa de Andrade ; Milena Botelho Pereira Soares ; Regina Celia Galvao Frem ; Rodrigo de Souza Corrêa ; Silvana Guilardi
• Associated research grant: 17/15850-0 - X-ray diffraction as a tool in potential drug development, AP.TEM
• EMU web page: Página do Equipamento Multiusuário não informada
• Type of equipment: Caracterização de Materiais - Difração - Raios-X (inclui SAXS)
• Manufacturer: Fabricante não informado
• Model: Modelo não informado

Abstract

The present project aims the study of intermolecular interactions in transition metal complexes with organic ligands, with the objective of establishing the mechanism of action of these compounds as potential anticancer drugs, antituberculosis, antichagasic or antimalarial drugs. These studies consist of several steps that include the synthesis of the compounds, their spectroscopic characterizations (Raman, infrared, UV and occasionally EPR), the determination of their biological activities at specific targets, their crystallization to allow the determination of three-dimensional geometry by single crystal x-ray diffraction and fundamentally perform their structural determination. This last stage is fundamental to the understanding of the intermolecular interactions among the species and assumes a character of paramount importance. Therefore, it is necessary to acquire a single crystal X-ray diffractometer to be use as a tool for the structural determination of the compounds to be obtained by the team of researchers (physicists, chemists and biologists) that form the group involved in the project. In this way, the main investment of the project is the acquisition of a last generation single crystal X-ray diffractometer. This equipment is intended to replace the former Enraf-Nonius diffractometer acquired in the Thematic Project Process no. 98/12151-1 in 1998 (coordinated by the same researcher of the present request), which reached the limit of its useful life, not before allowing more than 300 published works in magazines with excellent impact parameters. The original CCD detector is currently out of line and last year we had to replace it with a used one kindly provided, at no cost, by Enraf-Nonius (currently absorbed by Bruker) and whose efficiency has already shown signs of irreversible obsolescence. Moreover, its outdated technology does not allow measurements with the precision and speed of the most modern equipment, which are fundamental to conducting competitive research in the modern world. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE ARAUJO-NETO, JOAO HONORATO; GUEDES, ADRIANA P. M.; LEITE, CELISNOLIA M.; MORAES, CARLOS ANDR E F.; SANTOS, ANDRESSA L.; BRITO, RAFAELLA DA S.; ROCHA, THIAGO L.; MELLO-ANDRADE, FRANCYELLI; ELLENA, JAVIER; BATISTA, ALZIR A.. ?Half-Sandwich? Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies. Inorganic Chemistry, v. 62, n. 18, p. 15-pg., 2023-04-26. (21/04876-4, 17/15850-0, 21/02522-0)

ALVES, KAMILLA M.; HONORATO, JOAO; LIAO, LUCIANO M.; VELOZO-SA, VIVIANNE S.; GUEDES, ADRIANA P. M.; DUTRA, JOCELY DE L.; AYALLA, ALEJANDO P.; ELLENA, JAVIER; BATISTA, ALZIR A.; GONCALVES, PABLO J.. meso-Tetra-(4-pyridyl)porphyrin/palladium(ii) complexes as anticancer agents. DALTON TRANSACTIONS, v. 50, n. 44, SEP 2021. (21/02522-0, 21/04876-4, 18/19342-2, 17/15850-0)

COLINA-VEGAS, LEGNA; SILVA, MARIANA DA CRUZ B.; DE SOUZA PEREIRA, CAROLINE; BARROS, ARIANE ISIS; NOBREGA, JOAQUIM ARAUJO; NAVARRO, MARIBEL; ROTTMANN, MATTHIAS; D'ALESSANDRO, SARAH; BASILICO, NICOLETTA; BATISTA, ALZIR AZEVEDO; et al. Antimalarial Agents Derived from Metal-Amodiaquine Complexes with Activity in Multiple Stages of the Plasmodium Life Cycle. CHEMISTRY-A EUROPEAN JOURNAL, v. N/A, p. 15-pg., 2023-08-18. (16/23130-5, 17/15850-0, 21/02522-0)

SOUSA, CAROLINE C.; DZIWORNU, GODWIN AKPEKO; QUADROS, HELENITA C.; ARAUJO-NETO, JOAO HONORATO; CHIBALE, KELLY; MOREIRA, DIOGO R. M.. Antimalarial Pyrido[1,2-a]benzimidazoles Exert Strong Parasiticidal Effects by Achieving High Cellular Uptake and Suppressing Heme Detoxification. ACS INFECTIOUS DISEASES, v. 8, n. 8, p. 11-pg., 2022-07-18. (21/02522-0, 21/04876-4)

CAIRO, RAUL RAMOS; PLUTIN, ANA MARIA; CASTELL, RAUL OSCAR MOCELO; CASTELLANO, EDUARDO E.; CORREA, RODRIGO S.; GONZALEZ, DIANA L. NOSSA; ERBEN, MAURICIO F.; COMINETTI, MARCIA REGINA; LEITE, CELISNOLIA MORAIS; DE OLIVEIRA, TAMIRES DONIZETH; et al. Dynamics of Formation of Binuclear Metal Complexes: A New Cu(I) Compound with N-(2-thiophenecarbonyl)-N'-(3-Cl, 4-F-phenyl)thiourea as Ligand. CHEMISTRYSELECT, v. 7, n. 29, p. 8-pg., 2022-08-05. (20/14561-8, 21/02522-0, 17/15850-0)