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The role of Chemistry in holobiont adaptation

Grant number: 19/17721-9
Support Opportunities:Research Projects - Thematic Grants
Duration: March 01, 2022 - February 28, 2027
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Roberto Gomes de Souza Berlinck
Grantee:Roberto Gomes de Souza Berlinck
Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Pesquisadores principais:
Igor Dias Jurberg ; Rafael Victorio Carvalho Guido ; Solange Oliveira Rezende
Associated researchers:Antonio Gilberto Ferreira ; Camila Manoel Crnkovic ; Danilo Ciccone Miguel ; Diego Furtado Silva ; EDUARDO CARLOS MEDUNA HAJDU ; Fernanda Fernandes Cavalcanti ; Fernanda Ramos Gadelha ; Gustavo Enrique de Almeida Prado Alves Batista ; Leandro Manzoni Vieira ; Marcelo Brocchi ; Raquel Alves dos Santos ; Ricardo Marcondes Marcacini ; Ronaldo Aloise Pilli ; Rosana Moreira da Rocha ; Severino Matias de Alencar ; Simone Possedente de Lira ; Taicia Pacheco Fill ; Tiago Venancio ; Vinicius Padula Anderson
Associated scholarship(s):24/04949-0 - Discovery of natural products isolated from fungal lineages as lead candidates for Malaria, BP.PD
23/17676-9 - Biodiscovery and biosynthesis of secondary metabolites from bacteria and marine fungi, BP.DD
23/09209-1 - Desing and development of Plasmodium falciparum PI4K and PKG dual inhibitors as lead candidates for Malaria, BP.PD
+ associated scholarships 23/07721-7 - Screening of a library of synthetic and natural compounds for antibacterial activity to ESKAPE group bacterial strains, BP.IC
23/07611-7 - Studies Aiming at the Synthesis of Guanidines with Potential Antiplasmodial Activity, BP.IC
23/03907-9 - Conctruction of a library of secondary metabolites from microoganisms and marine organisms for the discovery of bioactive molecules, BP.TT
23/02821-3 - Chemical and biological study of secondary metabolites of the sponge Aplysina alcicornis, BP.IC
23/03479-7 - Hyperparameter Optimization in Deep Learning, BP.IC
22/13198-2 - Preparation of Guanidine Derivatives for SAR Studies against Parasitic Diseases, BP.PD
22/10471-0 - Databank of Microbial Images for the Development of Recognition by Artificial Intelligence, BP.TT
22/16075-9 - Investigation of Explanation Methods for Deep Learning, BP.IC
22/01529-4 - Bioactivity of secondary metabolites produced by actinobacteria from the bulk soil of Paullinia cupana Mart. against soybean phytopathogens, BP.DR
22/14278-0 - Construction of a Library of Secondary Metabolites of Micro-Organisms and Marine Organisms for the Discovery of Bioactive Molecules, BP.TT
22/12360-0 - Preparation of guanidine derivatives for sar studies against parasitic diseases, BP.DD
22/03594-8 - Understanding the chemical warfare and the virulence strategies of Penicillium digitatum involved in the pathogen- host interaction, BP.PD
22/01750-2 - Synthesis of guanidine derivatives exhibiting potential biological activities, BP.PD
21/07343-7 - Isolation and identification of hidrossoluble bioactive peptaibols from produced by the fungus Hypodrea sp., BP.IC
22/02176-8 - Deep learning feature extraction with limited data and processing, BP.PD
21/09852-6 - Evaluation of the antiproliferative potential of trichokonin VI and VIII peptaibols in MCF-7 and MDA-MB-231 breast Cancer cell lines, BP.IC
22/01066-4 - Discovery of natural products isolated from fungal lineages as lead candidates for Malaria, BP.PD
22/01063-5 - Characterization of the antiplasmodial activity of natural products isolated from fungal metabolites as lead candidates for Malaria, BP.DD
21/14554-4 - Screening of secondary metabolites from marine sponges from the south coastline of Bahia state, BP.IC
21/13089-6 - Semi-synthesis of heteroaromatic derivatives of (-)-palitantin for obtaining bioactive analogues, BP.IC
21/12629-7 - Descoberta de metabólitos fúngicos bioativos, BP.IC
20/12564-0 - Investigation of the biosynthesis of fungal terpenes, BP.DD - associated scholarships


A holobiont is constituted by a host and its whole ecological community of associated microbes. It is a unit of evolution, and the holobiont selection is a major evolutionary force. One feature which it is still poorly addressed is the role of secondary metabolites in microbes-host relationships, as well as in chemically mediated interactions between holobionts (the microbes-host ensemble) and the environment. In this proposal, we aim to investigate: selected aspects of marine sponge holobiont Chemistry and how the Chemistry is implied in marine sponge success; how microbes are involved in chemistry transfer from preys to predators in the marine environment; the Chemistry of selected groups of marine invertebrates and of microbes associated with invertebrates and plants, aiming to obtain novel bioactive chemicals; to further explore the Chemistry and Biology of already obtained lead compounds, in order to design more active and structurally less complex bioactive scaffolds, aiming to further explore the Pharmacology of these compounds; to investigate the biosynthesis of two selected groups of microbial metabolites, in order to unveil gene clusters and enzymes involved in biosynthetic steps and to envisage Bioengineered structural modifications to improve biological activity; to develop an unprecedented approach for the automated selection of microorganisms. The ultimate aim is to answer selected challenging questions, in order to advance the knowledge of holobionts adaptation, and to explore useful chemicals that influence holobionts adaptation and that result from holobionts success in Nature. (AU)

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Scientific publications (16)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LEAL, CAMILLE, V; AVELINO-ALVES, DHARA; SALAZAR, VINICIUS; OMACHI, CLAUDIA; THOMPSON, CRISTIANE; BERLINCK, ROBERTO G. S.; HAJDU, EDUARDO; THOMPSON, FABIANO. Sponges present a core prokaryotic community stable across Tropical Western Atlantic. Science of The Total Environment, v. 835, p. 15-pg., . (19/17721-9, 15/01017-0, 13/50228-8)
GALLO, RAFAEL D. C.; CARIELLO, GUILHERME; GOULART, TALES A. C.; JURBERG, IGOR D.. Visible light-mediated photolysis of organic molecules: the case study of diazo compounds. CHEMICAL COMMUNICATIONS, v. 59, n. 48, p. 15-pg., . (22/01104-3, 20/00144-6, 22/01750-2, 19/17721-9)
DE AMORIM, MARCELO R.; BARBOSA, CAMILA DE S.; PAZ, TIAGO A.; IOCA, LAURA P.; NICACIO, KAREN J.; DE OLIVEIRA, LUCIANNE F. P.; GOULART, MIRIAN O.; PAULINO, JULIA M.; DA CRUZ, MATEUS O.; FERREIRA, ANTONIO G.; et al. Polyketide- and Terpenoid-Derived Metabolites Produced by a Marine-Derived Fungus, Peroneutypa sp.. Journal of Natural Products, v. 86, n. 6, p. 11-pg., . (19/17721-9, 16/05133-7, 15/01017-0, 20/12904-5, 20/01229-5)
PEREZ-VARGAS, JIMENA; SHAPIRA, TIROSH; OLMSTEAD, ANDREA D.; VILLANUEVA, IVAN; THOMPSON, CONNOR A. H.; ENNIS, SIOBHAN; GAO, GUANG; DE GUZMAN, JOSHUA; WILLIAMS, DAVID E.; WANG, MENG; et al. Discovery of lead natural products for developing pan-SARS-CoV-2 therapeutics. Antiviral Research, v. 209, p. 13-pg., . (19/17721-9)
FREIRE, VITOR F.; GUBIANI, JULIANA R.; SPENCER, TARA M.; HAJDU, EDUARDO; FERREIRA, ANTONIO G.; FERREIRA, DAYANA A. S.; DE CASTRO LEVATTI, ERICA, V; BURDETTE, JOANNA E.; CAMARGO, CARLOS HENRIQUE; TEMPONE, ANDRE G.; et al. Feature-Based Molecular Networking Discovery of Bromopyrrole Alkaloids from the Marine Sponge Agelas dispar. Journal of Natural Products, v. 85, n. 5, p. 11-pg., . (19/17721-9, 17/06014-4, 20/03637-3, 13/50228-8, 21/04464-8)
FRANCHIN, MARCELO; SALIBA, ANA SOFIA MARTELLI CHAIB; SARTORI, ALAN GIOVANINI DE OLIVEIRA; NETO, SEBASTIAO ORESTES PEREIRA; BENSO, BRUNA; IKEGAKI, MASAHARU; WANG, KAI; ALENCAR, SEVERINO MATIAS DE; GRANATO, DANIEL. Food-grade delivery systems of Brazilian propolis from Apis mellifera: From chemical composition to bioactivities in vivo. Food Chemistry, v. 432, p. 14-pg., . (19/11248-0, 19/17721-9, 19/17426-7)
BARROS, ELCIO DANIEL SOUSA; MONCAO FILHO, EVALDO DOS SANTOS; PIO, YARA POLIANNA FONSECA; DE AMORIM, MARCELO RODRIGUES; BERLINCK, ROBERTO G. S.; MOURA, RITA DE CASSIA; FONSECA, MARILUCE GONCALVES; DANTAS, CLECIO; COELHO, RONALDO CUNHA; DA SILVA, GUILHERME RAMOS; et al. Comparative study of composition of methanolic extracts of the paratoid gland secretions (PGS) of Rhinella jimi (cururu toad) from northeastern Brazil: Gender, seasonality and geographic occurrence. Toxicon, v. 214, p. 10-pg., . (19/17721-9, 20/01229-5, 13/50228-8, 15/01017-0)
GUBIANI, JULIANA R.; BERNARDI, DARLON I.; DE PAULA, CAIO C. P.; SELEGHIM, MIRNA H. R.; FERREIRA, ANTONIO G.; BATISTA, ANDREA N. L.; BATISTA, JOAO M.; OLIVEIRA, LUCIANNE F. P.; LIRA, SIMONE P.; BURDETTE, JOANNA E.; et al. Absolute configuration of cytotoxic anthraquinones from a Brazilian cave soil-derived fungus, Aspergillus sp. SDC28. ARCHIV DER PHARMAZIE, v. 355, n. 4, p. 8-pg., . (17/12436-9, 17/06014-4, 19/17721-9, 19/22319-5, 13/50228-8, 16/21341-9)
XAVIER, EVERTHON A.; ALMEIDA, ANA C. S.; NOGUEIRA, MARCOS M.; VIEIRA, LEANDRO M.. Effects of substratum type and orientation on the recruitment of bryozoans in an artificial area of the Western Atlantic. BIOFOULING, v. N/A, p. 15-pg., . (19/17721-9)
MAIMONE, NAYDJA MORALLES; POZZA JR, MARIO CEZAR; DE OLIVEIRA, LUCIANNE FERREIRA PAES; ROJAS-VILLALTA, DORIAN; DE LIRA, SIMONE POSSEDENTE; BARRIENTOS, LETICIA; NUNEZ-MONTERO, KATTIA. Metabologenomics analysis of Pseudomonas sp. So3.2b, an Antarctic strain with bioactivity against Rhizoctonia solani. FRONTIERS IN MICROBIOLOGY, v. 14, p. 13-pg., . (22/01529-4, 19/17721-9)
OLIVEIRA, LEANDRO DA SILVA; CRNKOVIC, CAMILA M. M.; DE AMORIM, MARCELO R. R.; NAVARRO-VAZQUEZ, ARMANDO; PAZ, TIAGO A. A.; FREIRE, VITOR F. F.; TAKAKI, MIRELLE; VENANCIO, TIAGO; FERREIRA, ANTONIO G. G.; SAITO, RENATA DE FREITAS; et al. Phomactinine, the First Nitrogen-Bearing Phomactin, Produced by Biatriospora sp. CBMAI 1333. Journal of Natural Products, v. N/A, p. 8-pg., . (13/50228-8, 19/00447-1, 20/01229-5, 19/17721-9)
PISSINATI, EMANUELE F.; DELGADO, JOSE A. C.; MORO, PEDRO A. M.; CORREIA, JOSE T. M.; BERLINCK, ROBERTO G. S.; PAIXAO, MARCIO W.. Expanding the Chemical Space of Non-Proteinogenic N-4-Substituted Asparagine: Racemic, Enantioenriched, and Deuterated Derivatives. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, v. 26, n. 21, p. 7-pg., . (17/10015-6, 15/01017-0, 21/06099-5, 19/17721-9)
BARBOSA, CAMILA S.; AHMAD, ANEES; MALUF, SARAH EL CHAMY; MOURA, IGOR M. R.; SOUZA, GUILHERME E.; GUERRA, GIOVANNA A. H.; BARROS, ROBERTO R. MORAES; GAZARINI, MARCOS L.; AGUIAR, ANNA C. C.; BURTOLOSO, ANTONIO C. B.; et al. Synthesis, Structure-Activity Relationships, and Parasitological Profiling of Brussonol Derivatives as New Plasmodium falciparum Inhibitors. PHARMACEUTICALS, v. 15, n. 7, p. 21-pg., . (13/07600-3, 21/03977-1, 20/14429-2, 19/17721-9, 19/19708-0, 20/12904-5, 18/06219-8, 15/20084-0, 18/07287-7, 13/18009-4, 21/14319-5)
ORR, RUSSELL J. S.; DI MARTINO, EMANUELA; RAMSFJELL, MALI H.; GORDON, DENNIS P.; BERNING, BJORN; CHOWDHURY, ISMAEL; CRAIG, SEAN; CUMMING, ROBYN L.; FIGUEROLA, BLANCA; FLORENCE, WAYNE; et al. Paleozoic origins of cheilostome bryozoans and their parental care inferred by a new genome-skimmed phylogeny. SCIENCE ADVANCES, v. 8, n. 13, p. 11-pg., . (19/17721-9)
TAKAKI, MIRELLE; WILLIAMS, DAVID E.; FREIRE, VITOR F.; SARTORI, SERGIO B.; LIRA, SIMONE P.; BIZARRIA JR, RODOLFO; RODRIGUES, ANDRE; DA COSTA, DANIELLE R. GONCALVES; AMORIM, MARCELO R. .; FERREIRA, ANTONIO G.; et al. Metabolomics Reveals a 26-Membered Macrolactone Produced by Endophytic Colletotrichum spp. from Alcatrazes Island, Brazil. ORGANIC LETTERS, v. N/A, p. 5-pg., . (20/01229-5, 13/50228-8, 18/03679-8, 15/14114-3, 19/17721-9)

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