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The role of Chemistry in holobiont adaptation

Grant number: 19/17721-9
Support type:Research Projects - Thematic Grants
Duration: March 01, 2022 - February 28, 2027
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Roberto Gomes de Souza Berlinck
Grantee:Roberto Gomes de Souza Berlinck
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Pesquisadores principais:
Igor Dias Jurberg ; Rafael Victorio Carvalho Guido ; Solange Oliveira Rezende
Assoc. researchers:Antonio Gilberto Ferreira ; Camila Manoel Crnkovic ; Danilo Ciccone Miguel ; Eduardo Carlos Meduna Hajdu ; Fernanda Fernandes Cavalcanti ; Fernanda Ramos Gadelha ; Gustavo Enrique de Almeida Prado Alves Batista ; Leandro Manzoni Vieira ; Marcelo Brocchi ; Raquel Alves dos Santos ; Ricardo Marcondes Marcacini ; Ronaldo Aloise Pilli ; Rosana Moreira da Rocha ; Severino Matias de Alencar ; Simone Possedente de Lira ; Taicia Pacheco Fill ; Tiago Venancio ; Vinicius Padula Anderson
Associated scholarship(s):22/12360-0 - Preparation of guanidine derivatives for sar studies against parasitic diseases, BP.DD
22/03594-8 - Understanding the chemical warfare and the virulence strategies of Penicillium digitatum involved in the pathogen- host interaction, BP.PD
22/01750-2 - Synthesis of guanidine derivatives exhibiting potential biological activities, BP.PD
+ associated scholarships 21/07343-7 - Isolation and identification of hidrossoluble bioactive peptaibols from produced by the fungus Hypodrea sp., BP.IC
22/02176-8 - Deep learning feature extraction with limited data and processing, BP.PD
21/09852-6 - Evaluation of the antiproliferative potential of trichokonin VI and VIII peptaibols in MCF-7 and MDA-MB-231 breast Cancer cell lines, BP.IC
22/01066-4 - Discovery of natural products isolated from fungal lineages as lead candidates for Malaria, BP.PD
22/01063-5 - Characterization of the antiplasmodial activity of natural products isolated from fungal metabolites as lead candidates for Malaria, BP.DD
21/14554-4 - Screening of secondary metabolites from marine sponges from the south coastline of Bahia state, BP.IC
21/12629-7 - Descoberta de metabólitos fúngicos bioativos, BP.IC
21/13089-6 - Semi-synthesis of heteroaromatic derivatives of (-)-palitantin for obtaining bioactive analogues, BP.IC
20/12564-0 - Investigation of the biosynthesis of fungal terpenes, BP.DD - associated scholarships


A holobiont is constituted by a host and its whole ecological community of associated microbes. It is a unit of evolution, and the holobiont selection is a major evolutionary force. One feature which it is still poorly addressed is the role of secondary metabolites in microbes-host relationships, as well as in chemically mediated interactions between holobionts (the microbes-host ensemble) and the environment. In this proposal, we aim to investigate: selected aspects of marine sponge holobiont Chemistry and how the Chemistry is implied in marine sponge success; how microbes are involved in chemistry transfer from preys to predators in the marine environment; the Chemistry of selected groups of marine invertebrates and of microbes associated with invertebrates and plants, aiming to obtain novel bioactive chemicals; to further explore the Chemistry and Biology of already obtained lead compounds, in order to design more active and structurally less complex bioactive scaffolds, aiming to further explore the Pharmacology of these compounds; to investigate the biosynthesis of two selected groups of microbial metabolites, in order to unveil gene clusters and enzymes involved in biosynthetic steps and to envisage Bioengineered structural modifications to improve biological activity; to develop an unprecedented approach for the automated selection of microorganisms. The ultimate aim is to answer selected challenging questions, in order to advance the knowledge of holobionts adaptation, and to explore useful chemicals that influence holobionts adaptation and that result from holobionts success in Nature. (AU)

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