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Autonomic (sympathetic and parasympathetic) modulation of cardiovascular and inflammatory responses under physiopathological clinical and experimental conditions

Grant number: 20/06043-7
Support Opportunities:Research Projects - Thematic Grants
Duration: May 01, 2021 - April 30, 2026
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Helio Cesar Salgado
Grantee:Helio Cesar Salgado
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Cláudia Helena Lovato da Silva ; Michel Reis Messora ; Rubens Fazan Junior
Associated researchers:Adriana Barbosa Ribeiro ; Adriana Campos Passanezi Santana ; Alexandre Kanashiro ; Aline Barbosa Ribeiro ; Carlos Augusto Fernandes Molina ; Carlos Ferreira dos Santos ; Elen Rizzi Sanchez ; Fábio Nelson Gava ; Heloísa Della Coletta Francescato ; José Carlos Farias Alves Filho ; Juliana Pfrimer Falcão ; Marcus Vinicius Simões ; Marina de Toledo Durand ; Michel Reis Messora ; Minna Moreira Dias Romano ; Renata Maria Lataro ; Sandra Yasuyo Fukada Alves ; Silvia Carolina Guatimosim Fonseca ; Terezila Machado Coimbra
Associated scholarship(s):22/07579-3 - Experimental periodontitis in genetically modified mice (VAChT and Super VAChT): cardiovascular and inflammatory aspects, BP.PD
22/05983-1 - Autonomic modulation - sympathy and parasympathic in: chronic Periodontitis investigated by variations in cardiac frequency, BP.DD
+ associated scholarships 22/04995-6 - Relationship of prevalence, microbial load of Candida species and degree of denture-related stomatitis with heart risk, BP.IC
22/00203-8 - Effect of doxycycline on cardiocirculatory autonomic control in heart failure induced by myocardial infarction in rats, BP.IC
21/08622-7 - Inflammatory and cardiovascular responses in Experimental Periodontitis, using the bilateral ligation of the first mandibular molar, in Spontaneously Hypertensive Rats (SHR), BP.PD
21/06988-4 - Relation of the Denture Stomatits (DRS) with cardiovascular risk and the effect of denture disinfection compared to local treatment on DRS remission and cardiac risk: controlled, randomized, double-blind clinical trial, BP.PD - associated scholarships


The Autonomic Nervous System (ANS) - Sympathetic and Parasympathetic - plays a role in the physiopathogenesis of cardiovascular diseases. Overall, there is a Sympathetic Overactivity contrasting with the Attenuation of Parasympathetic Function. It has also been demonstrated an interaction between the ANS and the Immune Systems (Innate and Adaptive), despite the mechanisms involved require more conspicuous examination. Besides, the interaction between the ANS and the Immune Systems (Innate and Adaptive) in the physiopathogenesis of Stomatitis and Periodontitis remains uncertain. To develop Experimental (Myocardial Infarction, Arterial Hypertension, Heart Failure, Periodontitis, and Stomatitis) and Clinical (Periodontitis and Stomatitis) protocols, with the purpose to better characterize the interaction of the ANS and the Immune Systems (Innate and Adaptive), and their causal relationship. Experimentally, it will be used rats (Wistar, Sprague-Dawley and Spontaneously Hypertensive Rats (SHR) and mice with attenuation (VAChT KD) or overexpression (Super VAChT) of the vesicular acetylcholine transporter. Clinically, it will be studied Patients with Periodontitis or Stomatitis. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
BROGNARA, FERNANDA; CASTANIA, JACI AIRTON; RIBEIRO, ALINE BARBOSA; SANTOS-JUNIOR, NILTON NASCIMENTO; SALGADO, HELIO CESAR. The Bezold-Jarisch Reflex and The Inflammatory Response Modulation in Unanesthetized Endotoxemic Rats. FRONTIERS IN PHYSIOLOGY, v. 12, . (13/20549-7, 20/06043-7, 18/10455-9, 18/20939-3, 17/05163-6)
RIBEIRO, ALINE BARBOSA; DA SILVA, THAIS MARQUES; SANTOS-JUNIOR, NILTON NASCIMENTO; CASTANIA, JACI AIRTON; FAZAN, JR., RUBENS; SALGADO, HELIO CESAR. Short-term effect of ligature-induced periodontitis on cardiovascular variability and inflammatory response in spontaneously hypertensive rats. BMC ORAL HEALTH, v. 21, n. 1, . (18/20939-3, 18/10455-9, 20/06043-7)

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