Serum vitamin D levels in COVID-19 patients: prevalence of hypovitaminosis and associated factors

• Grant number: 20/06725-0
• Support Opportunities: Regular Research Grants
• Start date: May 01, 2021
• End date: April 30, 2023
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Fábio Fernandes Neves
• Grantee: Fábio Fernandes Neves
• Host Institution: Centro de Ciências Biológicas e da Saúde (CCBS). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
• Associated researchers: Alceu Afonso Jordão Junior ; Anderson Ferreira da Cunha ; Caio César de Melo Freire ; Henrique Pott Junior ; Lucimar Retto da Silva de Avó ; Márcia Regina Cominetti ; Regina Vincenzi Oliveira ; Sigrid De Sousa dos Santos

Abstract

In December 2019, a new coronavirus was identified in Wuhan, China, as the agent of respiratory infections, including cases of respiratory failure and death. The virus called SARS-CoV-2 spread rapidly to more than 180 countries, including Brazil, causing an international alarm and pandemic declaration by the World Health Organization. However, despite the epidemiological importance, additional information on SARS-CoV- 2 are necessary to better understand the transmission, pathophysiology, disease severity factors and risks for the general population. Vitamin D has immunomodulatory properties, including the regulation of inflammatory cytokines, and may have a preventive role in the evolution of acute lung injury. It is plausible that vitamin D may have a protective role against SARS-CoV-2, reducing the severity of pneumonia and the progression to acute respiratory distress syndrome. However, there are no studies on the prevalence of hypovitaminosis D and the factors associated with this condition in the population of people infected with SARS-CoV-2. Considering this knowledge gap, the present study aims to assess serum vitamin D levels in hospitalized patients with SARS-CoV-2 infection, as well as to identify factors associated with this deficiency, especially inflammatory and oxidative stress variables. The project is an observational, cross-sectional study with patients of both sexes, aged 18 years or older and hospitalized with suspected SARS-CoV-2 infection. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NEVES, FABIO FERNANDES; POTT-JUNIOR, HENRIQUE; YAMASHITA, KAORI MARIA CAROLINA; SANTOS, SIGRID DE SOUSA; COMINETTI, MARCIA REGINA; FREIRE, CAIO CESAR DE MELO; DA CUNHA, ANDERSON FERREIRA; JORDAO, ALCEU AFONSO. Do the oxidative stress biomarkers predict COVID-19 outcome? An in-hospital cohort study. Free Radical Biology and Medicine, v. 207, p. 6-pg., 2023-10-01. (20/06725-0)

NEVES, FABIO FERNANDES; POTT-JUNIOR, HENRIQUE; SANTOS, SIGRID DE SOUSA; COMINETTI, MARCIA REGINA; DE MELO FREIRE, CAIO CESAR; DA CUNHA, ANDERSON FERREIRA; JORDAO, ALCEU AFONSO, JR.. Vitamin D deficiency predicts 30-day hospital mortality of adults with COVID-19. CLINICAL NUTRITION ESPEN, v. 50, p. 4-pg., 2022-07-21. (20/06725-0)