Exposure of diabetic children to high intensity sweeteners through the diet: an integrated approach on health risks and food regulation

• Grant number: 21/02387-6
• Support Opportunities: Regular Research Grants
• Start date: October 01, 2021
• End date: September 30, 2023
• Field of knowledge: Agronomical Sciences - Food Science and Technology - Food Science
• Principal Investigator: Adriana Pavesi Arisseto Bragotto
• Grantee: Adriana Pavesi Arisseto Bragotto
• Host Institution: Faculdade de Engenharia de Alimentos (FEA). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated researchers: Alline Artigiani Lima Tribst ; Regina Esteves Jordão ; Ricardo Manuel Abreu de Assunção
• Associated research grant(s): 24/06581-0 - 22nd World Congress of Food Science and Technology - IUFoST, AR.EXT
• Associated scholarship(s): 22/04679-7 - Validation of an analytical method for the determination of sweeteners in foods, beverages and table top sweeteners by LC-MS/MS, BP.TT

Abstract

Sweeteners are food additives commonly used as sugar substitutes in the diet of diabetic patients. The consumption of sweeteners is considered safe when their intake is below the Acceptable Daily Intake (ADI). National data on the intake of sweeteners are scarce, and there is no information on the exposure of diabetic children to these additives. Thus, this project aims to assess the intake of sweeteners (potassium acesulfame, aspartame, sodium cyclamate, saccharin, sucralose, steviol glycosides, neotame and advantame) by diabetic children aged 2 to 12 years and to verify the understanding of the labels of diet/light foods by their parents/guardians. The Estimated Daily Intake (EDI) of sweeteners will be calculated by deterministic and probabilistic models in Tier 3, using: i) food consumption information from a Food Frequency Questionnaire and ii) analytical data on the occurrence of sweeteners in commercial products, which will be obtained through a method to be developed and validated using high performance liquid chromatography coupled to mass spectrometry (LC-MS/MS). The EDI will be used to characterize the risk of sweetener consumption through its comparison with ADI. The understanding of labels will be assessed through an online questionnaire. It is expected that the data generated by this research can contribute to the establishment of regulatory and risk management actions in order to ensure the consumer's safety regarding the intake of sweeteners through the diet. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

TAKEHARA, CAROLINA T.; NICOLUCI, ICARO G.; ANDRADE, TALITA F. S.; ARISSETO-BRAGOTTO, ADRIANA P.. A comprehensive database of declared high-intensity sweeteners in Brazilian commercial products and updated exposure assessment. Food Research International, v. 161, p. 9-pg., 2022-09-08. (21/02387-6)

NICOLUCI, ICARO GOUVEA; DA SILVA, BEATRIZ SCARDUA; DE CAMPOS BRAGA, PATRICIA APARECIDA; BRAGOTTO, ADRIANA PAVESI ARISSETO. Simultaneous determination of nine high-intensity sweeteners in liquid and powder tabletop sweeteners. Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure, v. 40, n. 10, p. 9-pg., 2023-09-10. (21/02387-6)