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Untargeted metabolomics of inflammatory neuropathies: search for diagnostic and prognostic biomarkers

Abstract

Inflammatory neuropathies (IN) are serious autoimmune disease that affect the peripheral nerves through demyelination and axonal degeneration, causing a series of symptoms involving loss of sensitivity and motor ability. Two general types of INs will be focused in this project. The Guillan Barré Syndrome (GBS) as a group of acute NI, and the variants of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), which presents prolonged or recurrent course. Since such NIs are heterogeneous and variable, the diagnostic, prognostic and treatment response monitoring is not a straightforward task. Nowadays, the diagnostic of such neuropathies is based mainly on symptoms evidences, electrophysiological studies and laboratory tests. Therefore, the scientific and medical communities have expressed the necessity to find biomarkers to comprehend these neuropathies, aiming a more appropriate diagnostic, prognostic and effective treatment. However, NIs have been scarcely investigated by a metabolomic approach, and no study concerning the metabolic profile of GBS and CIDP have been performed. Furthermore, literature still lacks on studies about GBS prognostic biomarker's investigation, and none about CIDP. Such NIs research by a metabolomic approach would allow comprehension of underlying metabolic processes, as well as determination of potential differences on the beginning and during disease progress, providing information for future diagnosis and more specific treatment tools. Therefore, this project proposes an in-depth metabolomic analysis of serum from recently diagnosed NIs subjects, using samples collected upon diagnosis and along the patient treatment, as well as from healthy subjects. Metabolomic analyses will be performed by LC-MS/MS and GC-MS in order to find potential diagnosis and prognostic biomarkers. For this reason, this project represents an outstanding relevance due to clinical metabolomics application and contribution to public health sector, besides contributing to biochemical mechanisms' comprehension involved in such neuropathies. (AU)

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