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Brazilian high-risk cohort for psychiatric disorders: 10 years follow-up

Grant number: 21/05332-8
Support Opportunities:Research Projects - Thematic Grants
Duration: February 01, 2022 - January 31, 2027
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal Investigator:Rodrigo Affonseca Bressan
Grantee:Rodrigo Affonseca Bressan
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Pesquisadores principais:
João Ricardo Sato ; Síntia Iole Nogueira Belangero
Associated researchers: André Zugman ; Arthur Caye ; Ary Gadelha de Alencar Araripe Neto ; Carolina Cappi ; Carolina Muniz Felix de Carvalho ; Douglas Teixeira Leffa ; Eurípedes Constantino Miguel Filho ; Giovanni Abrahão Salum Júnior ; Jair de Jesus Mari ; Luis Augusto Paim Rohde ; Marcelo Camargo Batistuzzo ; Marcelo Queiroz Hoexter ; Marcos Leite Santoro ; Mauricio Scopel Hoffmann ; Nicolas Andres Crossley Karmelic ; Pedro Mario Pan Neto ; Roseli Gedanke Shavitt ; Síntia Iole Nogueira Belangero ; Vanessa Kiyomi Ota Kuniyoshi
Associated grant(s):23/00437-1 - Multi-user equipment approved in grant 2021/05332-8: Biomek i5 Automated Workstation, AP.EMU
Associated scholarship(s):23/02616-0 - Use of Graph convolutional neural networks in fMRI data for characterization of psychiatric disorders., BP.MS
22/15880-5 - Impact of genetic variants on structural neuroimaging: a longitudinal approach in psychiatric disorders, BP.DD
22/07782-3 - Assessment of child neurodevelopment through neuroimages and deep neural network models, BP.DD

Abstract

Psychiatric disorders are among the main causes of socio-occupational disability in western countries and their impact grows every year. Most of these psychiatric disorders begin in childhood or adolescence, with about one in ten children worldwide diagnosed with a psychiatric disorder. However, little investment in research is devoted to the study of mental disorders in this age group. Very little is known about the risk and protective factors in the trajectories related to the origin and course of these disorders. The investigation of these trajectories can bring important advances in the treatment and, mainly, in the prevention of these disorders. A total of 9,957 families from 57 schools in Porto Alegre and São Paulo were interviewed. Of these families, 2,511 participants were selected at the baseline (2010-2011), when information about them and their families was collected, especially parents and siblings. About 2,000 participants were reassessed three years later and 1,800 six years later. The present project plans to present the objectives, methods and justification for the reassessment of these participants in the 10-year follow-up. The main objective of this project is to seek environmental, genetic, neuropsychological and neuroimaging information from the aforementioned cohort in order to investigate the normal and abnormal trajectory of neurodevelopment, in addition to investigating risk and protective factors that may be related to mental health-related outcomes in childhood, adolescence and early adulthood. The aim of this project is to generate knowledge about neurobiological pathways of typical and atypical development and to identify and validate predictors capable of informing risk criteria to advance mental health prevention strategies. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS SANTOS, PEDRO MACHADO NERY; MENDES, SERGIO LEONARDO; BIAZOLI, CLAUDINEI; GADELHA, ARY; SALUM, GIOVANNI ABRAHAO; MIGUEL, EURIPEDES CONSTANTINO; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Assessing atypical brain functional connectivity development: An approach based on generative adversarial networks. FRONTIERS IN NEUROSCIENCE, v. 16, p. 12-pg., . (22/07782-3, 18/04654-9, 20/04119-6, 14/50917-0, 21/05332-8, 18/21934-5)
GRACCIELLE R. CUNHA; ARTHUR CAYE; PEDRO PAN; HELEN L. FISHER; RIVKA PEREIRA; CAROLINA ZIEBOLD; RODRIGO BRESSAN; EURÍPEDES CONSTANTINO MIGUEL; GIOVANNI A. SALUM; LUIS AUGUSTO ROHDE; et al. Identifying Depression Early in Adolescence: assessing the performance of a risk score for future onset of depression in an independent Brazilian sample. Revista Brasileira de Psiquiatria, v. 45, n. 3, p. 242-248, . (14/50917-0, 21/05332-8)
HONORATO-MAUER, JESSICA; XAVIER, GABRIELA; OTA, VANESSA KIYOMI; CHEHIMI, SAMAR NASSER; MAFRA, FERNANDA; CUOCO, CASSIA; ITO, LUCAS TOSHIO; ORMOND, RAFAELLA; ASPRINO, PAULA FONTES; OLIVEIRA, ADRIELLE; et al. Alterations in microRNA of extracellular vesicles associated with major depression, attention-deficit/hyperactivity and anxiety disorders in adolescents. TRANSLATIONAL PSYCHIATRY, v. 13, n. 1, p. 9-pg., . (17/25016-8, 17/05339-7, 21/09584-1, 08/57896-8, 20/02247-7, 14/50917-0, 21/05332-8, 16/19462-2)
SATO, JOAO RICARDO; PEREIRA, TIAGO DUARTE; MARTINS, CLARICE MARIA DE LUCENA; BEZERRA, THAYNA ALVES; QUEIROZ, MARIA EDUARDA; COSTA, LARISSA PEREIRA; ANDRADE, SUELLEN MARINHO; BIAZOLI, CLAUDINEI EDUARDO. A Novel Exploratory Graph-Based Analytical Tool for Functional Near-Infrared Spectroscopy in Naturalistic Experiments: An Illustrative Application in Typically Developing Children. BRAIN SCIENCES, v. 13, n. 6, p. 9-pg., . (18/04654-9, 19/27250-3, 18/21934-5, 21/05332-8)
REBELLO, KEILA; MOURA, LUCIANA MONTEIRO; ARANTES BUENO, ANA PAULA; PICON, FELIPE ALMEIDA; PAN, PEDRO MARIO; GADELHA, ARY; MIGUEL, EURIPEDES CONSTATINO; BRESSAN, RODRIGO AFFONSECA; ROHDE, LUIS AUGUSTO; SATO, JOAO RICARDO. Associations between Family Functioning and Maternal Behavior on Default Mode Network Connectivity in School-Age Children. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 10, p. 10-pg., . (21/05332-8, 18/04654-9, 14/50917-0, 16/19376-9, 18/21934-5)
MENDES, SERGIO LEONARDO; PINAYA, WALTER HUGO LOPEZ; PAN, PEDRO MARIO; JACKOWSKI, ANDREA PAROLIN; BRESSAN, RODRIGO AFFONSECA; SATO, JOAO RICARDO. Generalizability of 3D CNN models for age estimation in diverse youth populations using structural MRI. SCIENTIFIC REPORTS, v. 13, n. 1, p. 12-pg., . (18/04654-9, 22/07782-3, 18/21934-5, 21/05332-8)
SATO, JOAO RICARDO; BIAZOLI, CLAUDINEI EDUARDO; BUENO, ANA PAULA ARANTES; CAYE, ARTHUR; PAN, PEDRO MARIO; SANTORO, MARCOS; HONORATO-MAUER, JESSICA; SALUM, GIOVANNI ABRAHAO; HOEXTER, MARCELO QUEIROZ; BRESSAN, RODRIGO AFFONSECA; et al. Polygenic risk score for attention-deficit/hyperactivity disorder and brain functional networks segregation in a community-based sample. GENES BRAIN AND BEHAVIOR, v. N/A, p. 9-pg., . (18/04654-9, 16/13737-0, 13/08531-5, 21/05332-8, 16/04983-7, 18/21934-5)
AYAZ, HASAN; BAKER, WESLEY B.; BLANEY, GILES; BOAS, DAVID A.; BORTFELD, HEATHER; BRADY, KENNETH; BRAKE, JOSHUA; BRIGADOI, SABRINA; BUCKLEY, ERIN M.; CARP, STEFAN A.; et al. Optical imaging and spectroscopy for the study of the human brain: status report. NEUROPHOTONICS, v. 9, p. 65-pg., . (18/04654-9, 19/21962-1, 16/22990-0, 13/07559-3, 21/05332-8, 18/21934-5)
FERNANDA ROHRSETZER; JOANA BISOL BALARDIN; FELIPE PICON; JOÃO RICARDO SATO; LUCAS BATTEL; ANNA VIDUANI; PEDRO HENRIQUE MANFRO; LEEHYUN YOON; BRANDON A. KOHRT; HELEN L. FISHER; et al. A magnetic resonance imaging-based morphometric and structural covariance network study of Brazilian adolescents stratified by depression risk. Revista Brasileira de Psiquiatria, v. 45, n. 4, p. 318-326, . (18/04654-9, 21/05332-8, 18/21934-5)
PRISCILA BENITEZ; CAMILA DOMENICONI; AMANDA YUMI AMBRIOLA OKU; RAIMUNDO DA SILVA SOARES JUNIOR; FERNANDA YUMI RIBEIRO MORI; LINCOLN SASSAKI; THAINÁ LETÍCIA DOURADO MOURA; THARINY OLIVEIRA; LIZBETH CONTI DE CARVALHO OLIVEIRA; GIOVANA DA SILVA; et al. Análise da Viabilidade de Uso do FNIRS em Atividades Educacionais com Crianças e Jovens com Deficiência Intelectual e Autismo. Rev. bras. educ. espec., v. 29, . (18/21934-5, 20/04777-3, 19/25795-2, 21/05332-8, 08/57705-8)

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