AC Biosusceptometry: models, instrumentation and applications

• Grant number: 21/09829-4
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2022 - January 31, 2024
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: José Ricardo de Arruda Miranda
• Grantee: José Ricardo de Arruda Miranda
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Applying non-invasive, low cost and harmless techniques into biological studies is an old and still current translational challenge. Biomagnetic techniques, such as the AC Biosusceptometry (ACB) system, allow us to investigate these biological properties with unique features. The ACB technique, consolidated over the last years, provides several setups, which can be applied to different studies and models, including pharmacological analyses, influence of diseases on physiological properties and, recently, in vivo detection and characterization of magnetic nanoparticles. Dynamically monitoring and imaging nano-structures perfusion over gastrointestinal tract, kidneys, liver, brain and also blood stream is another aspect we intent to explore, since our method provides unique temporal resolution.In this context, another stage developed recently, with the international partnership of a PTB-Berlin group, was the process of solving the inverse problem. Through a detected signal, we sought to know, through physical/mathematical and computational methods, which is the geometry of the material that generated the signal. From these mathematical manipulations and through simulations in certain software, mainly Python, it was possible to obtain a higher quality image with quantitative information about the accumulation of magnetic material. Another point that the inverse problem affects is the improvement of the spatial resolution value of the system, influencing the image quality and being able to present a quantitative magnetic image, that is, expressed in the amount of magnetic material.Summarizing, in this project, we propose a multidisciplinary study, relating instrumentation development, biophysics, pharmacotechniques and also nanoparticles detection and monitoring, which will consolidate the AC Biosusceptometry technique as a valuable alternative tool to assess physiological and clinical parameters on biological systems. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SOARES, GUILHERME A.; FARIA, JOAO V. C.; PINTO, LEONARDO A.; PROSPERO, ANDRE G.; PEREIRA, GABRIELE M.; STOPPA, ERICK G.; BURANELLO, LAIS P.; BAKUZIS, ANDRIS F.; BAFFA, OSWALDO; MIRANDA, JOSE R. A.. Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry. MATERIALS, v. 15, n. 6, p. 14-pg., 2022-03-01. (19/11277-0, 13/07699-0, 21/09829-4)

BURANELLO, LAIS PEREIRA; DE ALBUQUERQUE BIASOTTI, GABRIEL GUSTAVO; PROSPERO, ANDRE GONCALVES; STOPPA, ERICK GUILHERME; SOARES, GUILHERME AUGUSTO; BAFFA, OSWALDO; WIEKHORST, FRANK; DE ARRUDA MIRANDA, JOSE RICARDO. Development and implementation of a tomographic system for the quantitative reconstruction of magnetic microparticles based on AC biosusceptometry sensors. Journal of Magnetism and Magnetic Materials, v. 579, p. 12-pg., 2023-06-01. (21/09829-4)

SOARES, GUILHERME; PINTO, LEONARDO; LIEBL, MAIK; BIASOTTI, GABRIEL; PROSPERO, ANDRE; STOPPA, ERICK; BAKUZIS, ANDRIS; BAFFA, OSWALDO; WIEKHORST, FRANK; ARRUDA MIRANDA, JOSE RICARDO. Quantitative imaging of magnetic nanoparticles in an unshielded environment using a large AC susceptibility array. JOURNAL OF BIOLOGICAL ENGINEERING, v. 16, n. 1, p. 11-pg., 2022-10-11. (21/09829-4, 19/11277-0, 13/07699-0)

SOARES, GUILHERME A.; PEREIRA, GABRIELE M.; ROMUALDO, GUILHERME R.; BIASOTTI, GABRIEL G. A.; STOPPA, ERICK G.; BAKUZIS, ANDRIS F.; BAFFA, OSWALDO; BARBISAN, LUIS F.; MIRANDA, JOSE R. A.. Biodistribution Profile of Magnetic Nanoparticles in Cirrhosis-Associated Hepatocarcinogenesis in Rats by AC Biosusceptometry. PHARMACEUTICS, v. 14, n. 9, p. 19-pg., 2022-09-01. (21/06405-9, 19/11277-0, 21/09829-4, 13/07699-0)