58S Bioglass scaffolds constructed from self-assembled cellulose nanocrystals and sol-gel

• Grant number: 21/11019-0
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2022 - January 31, 2024
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Celso Aparecido Bertran
• Grantee: Celso Aparecido Bertran
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Bioglasses represent a very promising class of biomaterials for the repair of bone tissue damage, due to their biocompatibility, bioactivity and osteoconductivity. They can be synthesized by two methods: melting and quenching and by Sol-Gel. The Sol-Gel is more versatile, allowing to prepare, in addition to monoliths, particles and porous structures called scaffolds, which have interconnected pores and with dimensions suitable for cellular invasion and permeation of body fluids, decisive processes for rapid bone regeneration. In this project, the use of cellulose nanocrystals functionalized with phosphate groups and Sol-Gel, will be explored for the preparation of 58S bioglass scaffolds (58% SiO2, 33% CaO, 9% P2O5, w / w%). Dispersions of cellulose nanocrystals functionalized with charged groups, undergo self-organization in structures called "Castle of Cards", when subjected to controlled conditions of zeta potential, centrifugation and freezing, followed by lyophiolization. These structures can be used as template to build bioglass scaffolds, through the association of self-organization and the "Sol", originated from Sol-Gel. The calcination of the self-organized structure resulting from the association of these two processes, at controlled temperatures and for a short period of time, burns the cellulose nanocrystals, consolidating and sintering the bioglass particles and giving rise to the scaffold. (AU)