Abstract
Raw materials from renewable sources, as well as agro-industrial waste, represent an attractive source of useful chemical functionalities, which to date is still largely untapped in terms of their application in the fine chemicals industry. Our research group has already identified continuous flow processing as a fundamental technology for the valorization of such materials, so that any designed methods can be rapidly scaled to manufacture. Many of the principles of Green Chemistry and Sustainability can be met by embracing new technologies that are inherently cleaner when compared to the current status quo. By designing new synthetic methods that take full advantage of the capabilities of different enabling technologies, one will inevitably end up with greener, cleaner processes.In this proposal, reactions will be explored in continuous flow regime, under microwave irradiation or under mechanochemical conditions in the processing of compounds derived from an extremely rich and abundant feedstock in Brazil: the biomass. The project comprises 3 strategic research axes, whose main objective is to explore the benefits of these three enabling technologies in the chemical conversion of biomass-derived compounds to obtaining platform molecules (Axis 1) and new chemicals or building blocks (Axis 2), as well as in the synthesis of bioactive compounds such as APIs and other relevant bioactive compounds (Axis 3).Analytical tools, such as design of experiments (DoE) will be employed in order to quickly map reaction conditions and assess the effect of various parameters, minimizing the time needed to optimizing processes. Likewise, continuous flow systems combined with in-line analytical tools and optimization algorithms will also be adopted in the development of new automated synthetic processes (so-called 'self-optimization'). The ability of self-optimization to efficiently identify optimal operating conditions in a multivariate parameter space has presented many opportunities for more efficient process development. Such advantages align with the rising interest in continuous flow chemistry towards the 'greener' synthesis of active pharmaceutical ingredients (APIs), and offer the potential to reduce the drug development timeline. Thus, the adoption of these tools is very timely. (AU)
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