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Maternal-fetal interface: immunopathogenesis and vaccinal intervention in viral infections

Abstract

Pregnancy is considered an active period of operative regulatory mechanisms for fetal development, but inflammatory disorders associated with viral infections may alter its outcome. This project addresses Human Immunodeficiency Virus (HIV) and Zika Virus (ZIKV) infection during pregnancy, both capable of congenital transmission with impact in the public health and do not yet have vaccine coverage. In HIV-1 infection with the advent of antiretrovirals, there has been a considerable reduction in vertical transmission and an increase in the number of HIV-exposed uninfected children who are more vulnerable to infectious processes in the first years of life. ZIKV infection can cause serious consequences such as ZIKV-associated Congenital Syndrome, and also to cause adverse effects in the postnatal period. Our project will investigate (I) microRNA profile at the maternal-fetal interface in HIV or ZIKV infection; (II) the influence of placental inflammation with a translational approach in mice in ZIKV infection; (III) immunological aspects of neutrophils of neonates in these infections and (V) the maternal DNA vaccine strategy for the prevention of congenital ZIKV. Understanding the occurrences at the maternal-fetal interface and strategies for preventing gestational viral infections, with anti-inflammatory and/or antiviral effects for congenital and perinatal anomalies, are essential attributes for maternal-child health quality. (AU)

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
GOZZI-SILVA, SARAH CRISTINA; OLIVEIRA, LUANA DE MENDONCA; ALBERCA, RICARDO WESLEY; PEREIRA, NATALLI ZANETE; YOSHIKAWA, FABIO SEITI; PIETROBON, ANNA JULIA; YENDO, TATIANA MINA; DE SOUZA ANDRADE, MILENA MARY; LEUZZI RAMOS, YASMIM ALEFE; BRITO, CYRO ALVES; et al. Generation of Cytotoxic T Cells and Dysfunctional CD8 T Cells in Severe COVID-19 Patients. CELLS, v. 11, n. 21, p. 18-pg., . (19/25119-7, 19/22448-0)
MANFRERE, KELLY CRISTINA GOMES; TORREALBA, MARINA PASSOS; FERREIRA, FREDERICO MORAES; DE SOUSA, EMANUELLA SARMENTO ALHO; MIYASHIRO, DENIS; TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; CUSTODIO, RICARDO WESLEY ALBERCA; NAKAYA, HELDER I.; RAMOS, YASMIN ALEFE LEUZZI; SOTTO, MIRIAN NACAGAMI; et al. Imbalanced IL-1B and IL-18 Expression in Sezary Syndrome. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 5, p. 13-pg., . (20/02190-5, 19/25119-7)
BEZERRA, WALLACE PITANGA; SALMERON, AMANDA COSTA AYRES; BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; MORAIS, INGRYD CAMARA; SALES, VALERIA SORAYA DE FARIAS; MACHADO, PAULA RENATA LIMA; SOUTO, JANEUSA TRINDADE; DE ARAUJO, JOSELIO MARIA GALVAO; GUEDES, PAULO MARCOS DA MATTA; SATO, MARIA NOTOMI; et al. Low CCL2 and CXCL8 Production and High Prevalence of Allergies in Children with Microcephaly Due to Congenital Zika Syndrome. Viruses-Basel, v. 15, n. 9, p. 14-pg., . (19/25119-7)
TEIXEIRA, FRANCIANE MOURADIAN EMIDIO; OLIVEIRA, LUANA DE MENDONCA; PIETROBON, ANNA JULIA; DE SALLES, ERIKA MACHADO; D'IMPERIO LIMA, MARIA REGINA; VIANA, ISABELLE FREIRE TABOSA; LINS, ROBERTO DIAS; RIGATO, PAULA ORDONHEZ; MARQUES, ERNESTO TORRES DE AZEVEDO; DA SILVA DUARTE, ALBERTO JOSE; et al. LAMP-1 Chimeric to HIV-1 p55Gag in the Immunization of Neonate Mice Induces an Early Germinal Center Formation and AID Expression. VACCINES, v. 10, n. 8, p. 14-pg., . (19/25119-7, 18/18230-6, 17/18199-9)
ALBERCA, RICARDO WESLEY; RAMOS, YASMIM ALEFE LEUZZI; PEREIRA, NATALLI ZANETE; BESERRA, DANIELLE ROSA; BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; ORFALI, RAQUEL LEAO; AOKI, VALERIA; DUARTE, ALBERTO JOSE DA SILVA; SATO, MARIA NOTOMI. Long-term effects of COVID-19 in diabetic and non-diabetic patients. FRONTIERS IN PUBLIC HEALTH, v. 10, p. 5-pg., . (20/13148-0, 19/02679-7, 19/25119-7)
BRANCO, ANNA CLAUDIA CALVIELLI CASTELO; DE OLIVEIRA, EMILY ARAUJO; PEREIRA, NATALLI ZANETE; ALBERCA, RICARDO WESLEY; DUARTE-NETO, AMARO NUNES; DA SILVA, LUIZ FERNANDO FERRAZ; LUIZ, FERNANDA GUEDES; PEREIRA, NAIURA VIEIRA; SOTTO, MIRIAN NACAGAMI; DEJANI, NAIARA NAIANA; et al. Obesity Induces an Impaired Placental Antiviral Immune Response in Pregnant Women Infected with Zika Virus. Viruses-Basel, v. 15, n. 2, p. 15-pg., . (15/03333-6, 19/26928-6, 19/25119-7, 17/07143-2)

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