Factors determining susceptibility to panic attacks: sex differences and search for novel pharmacotherapies

• Grant number: 21/14609-3
• Support Opportunities: Research Grants - Visiting Researcher Grant - International
• Start date: January 18, 2023
• End date: March 17, 2023
• Field of knowledge: Biological Sciences - Pharmacology - Neuropsychopharmacology
• Principal Investigator: Hélio Zangrossi Júnior
• Grantee: Hélio Zangrossi Júnior
• Visiting researcher: Thelma Lovick
• Visiting researcher institution: University of Bristol , England
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• City of the host institution: Ribeirão Preto

Abstract

Anxiety-related disorders are the most prevalent class of mental illnesses and twice as common in women compared to men. Early life adversity can significantly increase the risk of developing panic psychopathology in adulthood. At present, one-third of patients are refractory to treatment; there is a pressing need for further research to identify effective treatments. The project focuses on panic behavior. We will utilize two behavioral tests in rats, which have been designed to model respiratory and non-respiratory forms of panic in humans. We will compare responsiveness of males and females, paying particular attention to responsiveness at different stages of the estrous cycle in females, and whether early life stress as a consequence of maternal deprivation increases susceptibility to panic and whether there is differential sensitivity to respiratory and non-respiratory panicogenic challenge. The second part of the study will investigate the effectiveness of two novel potential anti-panic drugs, which our preliminary data indicate may be particularly effective in females. These are low dose fluoxetine (subthreshold for effects on 5-HTsystems) and cannabidiol. (AU)

Scientific publications

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

VILELA-COSTA, HELOISA HELENA; HERNANDES, PALOMA MOLINA; NASCIMENTO-SILVA, JEFFERSON MANOEL; FRIAS, ALANA TERCINO; ALMADA, RAFAEL CARVALHO; LOVICK, THELMA ANDERSON; ZANGROSSI JR, HELIO. Neonatal limited bedding and nesting experience may lead to a sex-dependent increase in panic-like defensive behaviours in adult mice. European Journal of Neuroscience, v. N/A, p. 12-pg., 2024-09-08. (21/14609-3)

HERNANDES, PALOMA MOLINA; BATISTELA, MATHEUS FITIPALDI; NASCIMENTO-SILVA, JEFFERSON MANOEL; FRIAS, ALANA TERCINO; MATTHIESEN, MELINA; CAMPOS, ALLINE CRISTINA; LOVICK, THELMA ANDERSON; ZANGROSSI JR, HELIO. Sex and estrous cycle-linked differences in the effect of cannabidiol on panic-like responding in rats and mice. Behavioural Brain Research, v. 455, p. 8-pg., 2023-09-20. (21/14609-3)