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Salivary biomarkers of COVID-19 and other viral respiratory infections

Grant number: 21/07490-0
Support type:Regular Research Grants
Duration: March 01, 2022 - February 29, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Paulo Henrique Braz da Silva
Grantee:Paulo Henrique Braz da Silva
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers: Bengt Olof Valter Hasséus ; Camila Malta Romano ; Giuseppe Palmisano ; Herculano da Silva Martinho ; José Angelo Lauletta Lindoso ; Keity Souza Santos ; Kelvin To ; Louise Zanella Martins ; Luiz Fernando Ferraz da Silva ; Simone Giannecchini ; Vanessa Salete de Paula

Abstract

COVID-19 is an emerging disease caused by the coronavirus SARS-CoV-2, which was first identified in China and then spread over other countries, thus being considered a pandemic by the World Health Organization (WHO). The disease is mainly characterised by fever, dry cough, myalgia and arthralgia, and may take a mild, moderate or severe form depending on the clinical involvement. Its diagnosis is mainly based on detecting viral RNA in nasopharyngeal specimens collected by swab. Saliva has been shown to be a less invasive alternative for detecting SARS-CoV-2, in addition to allowing the analysis of biomarkers which may be related to both diagnosis and prognosis of the disease. In this study project, we will evaluate the use of saliva for diagnosis and follow-up of COVID-19, as well as possible coinfections with other respiratory viruses. The saliva specimens will be used for evaluation not only of the immune-inflammatory response in patients diagnosed with COVID-19 regarding the mild, moderate and severe forms, but also of the viral excretion kinetics at different times by means of weekly collections until the outcome was achieved (i.e. hospital discharge or death). The immune-humoral response will be also evaluated by detecting IgM, IgG and IgA antibodies at the different experimental times. The metabolomic and proteomic profiles will be also determined by using vibrational spectroscopic techniques (Raman, SERS and FT-IR) and MALDI-TOF-MS. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LAZARI, LUCAS C.; ZERBINATI, RODRIGO M.; ROSA-FERNANDES, LIVIA; SANTIAGO, VERONICA FEIJOLI; ROSA, KLAISE F.; ANGELI, CLAUDIA B.; SCHWAB, GABRIELA; PALMIERI, MICHELLE; SARMENTO, DMITY J. S.; MARINHO, CLAUDIO R. F.; et al. ALDI-TOF mass spectrometry of saliva samples as a prognostic tool for COVID-1. OURNAL OF ORAL MICROBIOLOG, v. 14, n. 1, . (18/15549-1, 20/06409-1, 20/04923-0, 18/18257-1, 15/26722-8, 17/03966-4, 21/07490-0, 18/20468-0)

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