Synthesis of nanostructured copper and silver complexes for replacement of growth-promoting antibiotics in swine and poultry production

• Grant number: 22/00208-0
• Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE
• Start date: July 01, 2022
• End date: June 30, 2024
• Field of knowledge: Agronomical Sciences - Animal Husbandry - Animal Nutrition and Feeding
• Principal Investigator: Camila Neves Lange
• Grantee: Camila Neves Lange
• Company: Brazilian Nano Feed Pesquisa e Desenvolvimento de Aditivos Ltda
• CNAE: Pesquisa e desenvolvimento experimental em ciências físicas e naturais
• City: Santo André
• Pesquisadores principais: Hebert Silveira
• Associated research grant: 20/00766-7 - Synthesis of copper and silver nanostructured complexes to replace growth-promoting antibiotics in swine and poultry production, AP.PIPE
• Associated scholarship(s): 23/13360-7 - Determination of copper and silver in tissues of poultry and swine fed diets containing complexes nanostructured copper and silver, BP.TT; 22/10619-7 - Synthesis of nanostructured copper and silver complexes to replace growth promoting antibiotics in swine and poultry production, BP.TT; 22/08618-2 - Synthesis of nanostructured copper and silver complexes for replacement of growth-promoting antibiotics in swine and poultry production, BP.PIPE

Abstract

The productive sector of animal proteins is growing rapidly. Poultry and pork are cheaper sources of protein when compared to beef, contributing to reduce food insecurity through the population's access to meat products. In addition, the sector offers millions of jobs to diverse people. The success of swine and poultry production has been vastly enhanced by the provision of antimicrobial agents in therapeutic underdoses, known as growth-promoting antibiotics (APC). However, the use of antibiotics in this way can lead to microbial resistance and it is estimated that by 2050 microbial resistance will be the leading cause of death in the world, therefore, a ban on APC is an inevitable path. As alternative additives to APC are rare on the market, and the vast majority do not have the same effectiveness in preventing diseases and promoting growth, nanostructured composites based on copper and silver were developed in Phase I of this project, as they have great potential for the replacement of APCs in pork and poultry production. Since the viability of the synthesis and antimicrobial action of these nanostructured composites was confirmed on a laboratory scale by the results of Phase I of this project, it is proposed in Phase II to obtain these composites on a pilot scale (semi-industrial) and to evaluate the technical feasibility of these applications, through in vivo evaluations of efficacy, safety and residues in poultry and pigs. (AU)