Understanding the causes of obstructive sleep apnoea (OSA) in co-morbid insomnia and obstructive sleep apnoea (COMISA) and assessing its impact on treatment management

• Grant number: 22/03564-1
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2022
• End date: July 31, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Agreement: Monash University
• Principal Investigator: Pedro Rodrigues Genta
• Grantee: Pedro Rodrigues Genta
• Principal researcher abroad: Bradley Edwards
• Institution abroad: Monash University, Australia
• Host Institution: Instituto do Coração Professor Euryclides de Jesus Zerbini (INCOR). Hospital das Clínicas da Faculdade de Medicina da USP (HCFMUSP). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated researchers: Geraldo Lorenzi Filho
• Associated research grant: 18/20612-4 - Pathophysiology of Obstructive Sleep Apnea applied to therapeutic improvement, AP.JP

Abstract

Co-morbid insomnia and obstructive sleep apnoea (COMISA) is common, with up to 40% of individuals with obstructive sleep apnoea (OSA) or insomnia meeting diagnostic criteria for both conditions. Cognitive behavioural therapy for insomnia (CBT-I) reduces OSA severity in COMISA patients, suggesting that these conditions may have some underlying shared cause(s). This project will be the first to identify the physiological mechanism(s) causing OSA in COMISA patients and how either treatment of insomnia (CBT-I) or OSA (CPAP) may influence these mechanism(s). This study will provide the critical information required to better target treatment interventions for these highly vulnerable patients. (AU)