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Solutions for emerging diseases in fish farming: diagnosis, vaccines and breeding

Grant number: 21/11955-8
Support Opportunities:Research Grants - Science Centers for Development
Duration: June 01, 2022 - May 31, 2027
Field of knowledge:Agronomical Sciences - Fishery Resources and Fishery Engineering - Aquaculture
Principal Investigator:Maria José Tavares Ranzani de Paiva
Grantee:Maria José Tavares Ranzani de Paiva
Host Institution: Instituto de Pesca. Agência Paulista de Tecnologia dos Agronegócios (APTA). Secretaria de Agricultura e Abastecimento (São Paulo - Estado). São Paulo , SP, Brazil
Pesquisadores principais:
Diogo Teruo Hashimoto ; Fabiana Pilarski ; Leonardo Tachibana ; Ricardo Luiz Moro de Sousa
Associated researchers:Antônio Fernando Gervásio Leonardo ; Carlos Massatoshi Ishikawa ; Cláudia Maris Ferreira Mostério ; Daniela Castellani ; Danielle de Carla Dias ; Eduardo Makoto Onaka ; Fernando Stopato da Fonseca ; Izabela Dutra Alvim ; Leonardo Susumu Takahashi ; Rafael Vilhena Reis Neto ; Silvia Helena Seraphin de Godoy ; Vander Bruno dos Santos
Associated scholarship(s):23/04314-1 - Vaccines development for Nile tilapia, BP.PD
23/04794-3 - Nile Tilapia Rapid Disease Diagnosis Kit and Vaccination Assessment Evaluation, BP.TT
23/01889-3 - Genetic selection for tilapia (Oreochromis niloticus) production resistant to diseases, BP.TT
23/01942-1 - Genomic selection for production of tilapia (Oreochromis niloticus) resistant to Francisella noatunensis, BP.PD
22/11636-2 - Solutions to combat emerging diseases in fish farming: Diagnostics, vaccines and genetic selection, BP.TT


Tilapia, Oreochromis ssp, is the second most cultivated fish in the world and the main specie produced in Brazil. The tilapia health is the main concern of the fish culture chain, and it has been significantly affected by emerging diseases caused by Francisella noatunensis subsp. orientalis (FNO) and, more recently, by the Infectious Necrosis of the Spleen and Kidney virus (ISKNV). The Fish Farming Health Center creation is necessary for the sustainable development of fish production in the State of São Paulo, to improve the technological knowledgments about national fish farming health problems. The objective of this Center will be development a diagnostic kits for emerging diseases, vaccines for these diseases and breeding to disease-related of tilapia. The project will be divided into three subprojects: 1) develop rapid diagnostic kits for FNO, and ISKNV detection based on chromatographic immunoassay test with monoclonal antibodies labeled with nanogold. An ELISA test will be developed to detect and quantify the IgM and identify the fish titration antibody after vaccination; 2) develop new vaccines for Nile tilapia against emerging fish farming diseases (Francisella noatunensis subsp. orientalis and the ISKNV virus); 3) genetic improvement for resistant/tolerant to diseases, with the objective of implementing a genetic selection program through genomics for the tilapia production chain. The potential impact of this study is to enable a technological package to boost the tilapia production chain in the aquaculture industry, with food safety, high genetic quality, added value and improvement in aquaculture health. (AU)

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