Understanding the charge transfer mechanisms in biological and biomimetic systems using in-situ and operando techniques: from fundamental science to energy application

• Grant number: 22/09164-5
• Support Opportunities: Regular Research Grants
• Duration: February 01, 2023 - January 31, 2025
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Frank Nelson Crespilho
• Grantee: Frank Nelson Crespilho
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated grant(s): 23/01529-7 - Bioengineering of bifunctional metalloproteins applied in the production of added value products, AP.R

Abstract

Redox processes play a critical role in maintaining life on Earth, and they are facilitated by biomolecules. In 2020, we described in Nature Communications how and why the copper-containing bilirubin oxidase (BOD) is an exceptional biocatalyst for the O2 reduction reaction (ORR). A longstanding goal of our research group is the establishment of new frontiers in in-situ techniques for the characterization of bioelectrocatalyst and the elucidation of the mechanism underlying the complex electrochemical reactions in which they are employed. Success in this endeavor would be ground-breaking in electrochemistry, as it would allow the further development of fuel cells sustainable batteries and thus contribute to the current efforts towards realizing clean energy. However, the synthesis of catalysts with three-dimensional organization remains challenging, and it opposes the prevailing trend which focuses on single atoms and two-dimensional materials. Here we propose an advance in the use of in-situ techniques and also in the preparation of mimetic batteries through the knowledge acquired in bioelectrocatalysis studies. For this, we propose 3 specific aims; the first two being for the realization of in-situ techniques to study biological and mimetic redox systems, and the last one for the development of bioinspired organic batteries, that can be applied in ingestible and wearable devices. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDES, GIOVANA ROSSI; MODENEZ, IAGO DE ASSIS; CAGNANI, GIOVANA ROSSO; COLOMBO, RAFAEL N. P.; CRESPILHO, FRANK NELSON. Exploring Enzymatic Conformational Dynamics at Surfaces through μ-FTIR Spectromicroscopy. Analytical Chemistry, v. 95, n. 30, p. 9-pg., 2023-07-17. (20/10724-0, 21/05665-7, 19/15333-1, 19/12053-8, 18/22214-6, 22/09164-5)

SEDENHO, GRAZIELA C.; COLOMBO, RAFAEL N. P.; CRESPILHO, FRANK N.. Insights from Enzymatic Catalysis: A Path towards Bioinspired High-Performance Electrocatalysts. CHEMCATCHEM, v. N/A, p. 18-pg., 2023-07-06. (21/05665-7, 22/09164-5, 18/22214-6, 20/04796-8)

MELO, ANTONIO F. A. A.; SINGH, SALAM J.; CHINNAMUTHU, PAULSAMY; CRESPILHO, FRANK N.; RYDZEK, GAULTHIER. Magnetically Stimulated Bio- and Electrochemical Systems: State-of-the-Art, Applications, and Future Directions. HEMNANOMA, v. N/A, p. 22-pg., 2023-07-19. (20/12404-2, 18/22214-6, 22/09164-5)

CASTRO, KARLA P. R.; COLOMBO, RAFAEL N. P.; IOST, RODRIGO M. M.; DA SILVA, BEATRIZ G. R.; CRESPILHO, FRANK N. N.. Low-dimensionality carbon-based biosensors: the new era of emerging technologies in bioanalytical chemistry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 17-pg., 2023-02-09. (22/09164-5, 21/05665-7, 18/22214-6)