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Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas

Grant number: 22/12760-9
Support Opportunities:Regular Research Grants
Duration: April 01, 2023 - March 31, 2025
Field of knowledge:Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
Principal Investigator:Jorge Esquiche León
Grantee:Jorge Esquiche León
Host Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated researchers:Alexandre Todorovic Fabro ; Andreia Bufalino ; Estela Kaminagakura Tango ; Fernando Chahud

Abstract

Head and neck squamous cell carcinoma (HNSCC) represents 95% of cancers in this anatomical region. Several studies evaluating the interrelationship of the immune system and cancer have demonstrated the ability of cancer cells to evade the immune response and promote a pro-tumor microenvironment. In addition to new markers of angiogenesis, proliferation and cell differentiation, recent studies show that transcription factors could efficiently determine the profile of tumor-infiltrating lymphocytes (TILs), in the context of stimulatory or inhibitory immune mechanisms (PD-1/PD-L1 axis). Cancer cells often reprogram metabolic pathways for survival, proliferation and metastasis. Although dependence on glycolysis is well studied, the role of "tumor-associated adipocytes (TAAs)" and lipid metabolic reprogramming in supporting cancer growth and proliferation, especially metastases, is less understood. Considering the human papillomavirus (HPV), several studies suggest that transcriptionally active HPV (in the HPV-driven context) is necessary to strictly associate a causal relationship of HPV in HNSCC. Thus, the present project intends to analyze through immunohistochemistry, in situ hybridization and molecular genetics a large series of HNSCC (n=500). The results will help to elucidate the immune and molecular mechanisms involved in the pathogenesis of HNSCC, in addition to providing data on lipid metabolism in tumor growth and metastasis, correlating them with the prevalence of transcriptionally active HPV and survival rates, in order to support therapeutic planning and prognosis. (AU)

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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SILVA, EVANIO VILELA; DE ANDRADE, BRUNO AUGUSTO BENEVENUTO; SILVEIRA, HEITOR ALBERGONI; ROCHA, EDUARDO MELANI; CHAHUD, FERNANDO; BRUNALDI, MARIANGELA OTTOBONI; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE. Characterization of ectopic germinal centers in Sjogren's syndrome (SS) and non-SS non-sicca patients. ORAL DISEASES, v. N/A, p. 5-pg., . (16/14636-2, 15/22586-2, 16/11419-0, 22/12760-9)
JAVARONI, JULIA BILIATO; SILVEIRA, HEITOR ALBERGONI; REYES, MAGDALENA RAQUEL TORRES; MESQUITA, ANA TEREZINHA MARQUES; ROCHA, GABRIELA FONSECA; LEON, JORGE ESQUICHE. Lip Granular Cell Tumor (GCT) in a Pediatric Patient: Critical Literature Review on Pediatric Intraoral GCT and Acquired and Congenital Intraoral Non-Neural GCT. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. N/A, p. 5-pg., . (16/11419-0, 22/12760-9)
SILVA, EVANIO VILELA; SILVEIRA, HEITOR ALBERGONI; CANDIDO MOREIRA, THALES PERES; AUGUSTO, JEFFERSON; RAGUSA SILVA, PAULA VERONA; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE. Non-Ulcerated and Ulcerated Necrotizing Sialometaplasia: Report of an Additional Case and Literature Review. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. 75, n. 3, p. 4-pg., . (18/12734-2, 16/11419-0, 17/01438-0, 22/12760-9)
SILVEIRA, HEITOR ALBERGONI; SILVA-SOUSA, YARA TERESINHA CORREA; REYES, MAGDALENA RAQUEL TORRES; BERNARDINI, VANESSA DA ROCHA; FLORIAM, LUIS JOSE; LEON, JORGE ESQUICHE. Pedunculated, papillary giant cell fibroma in a pediatric patient: An immunohistochemical and in situ hybridization study. PEDIATRIC DENTAL JOURNAL, v. 33, n. 1, p. 6-pg., . (16/11419-0, 18/12734-2, 22/12760-9)
AMARAL, ELOISA COSTA; JAVARONI, JULIA BILIATO; SILVEIRA, HEITOR ALBERGONI; TRIVELLATO, ALEXANDRE ELIAS; SVERZUT, CASSIO EDVARD; LEON, JORGE ESQUICHE. Pseudocarcinomatous Squamous Hyperplasia After Surgical Management Of Pediatric Ameloblastoma: An Immunohistochemical Study. JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, v. 22, n. 3, p. 5-pg., . (16/11419-0, 22/12760-9)
REYES, MAGDALENA RAQUEL TORRES; JAVARONI, JULIA BILIATO; NOGUEIRA, GUSTAVO MILHOMENS; ZELAYA, FLORENCE JUANA MARIA CUADRA; DE LEON, ANYELI SORAYA ALAS; SILVEIRA, HEITOR ALBERGONI; LEON, JORGE ESQUICHE. Resolution of blood eosinophilia and limited mouth opening after short-term follow-up in a pediatric Langerhans cell histiocytosis case. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. 75, n. 3, p. 4-pg., . (16/11419-0, 22/12760-9)
REYES, MAGDALENA RAQUEL; LOPES DOMINGUETE, MATHEUS HENRIQUE; JAVARONI, JULIA BILIATO; DA SILVEIRA, HEITOR ALBERGONI; SILVA, EVANIO VILELA; LEON, JORGE ESQUICHE. Lingual Actinomycosis Clinically Simulating Nodular Median Rhomboid Glossitis: Literature Review and Report of Additional Case. INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, v. N/A, p. 4-pg., . (16/11419-0, 22/12760-9)
SILVEIRA, HEITOR ALBERGONI; JAVARONI, JULIA BILIATO; FERREIRA DA SILVA, ANDERSON TANGERINO; TORRES REYES, MAGDALENA RAQUEL; HASHIMOTO, JENNIFER MAYUMI; CUADRA-ZELAYA, FLORENCE JUANA MARIA; LOPES DOMINGUETE, MATHEUS HENRIQUE; MARQUES MESQUITA, ANA TEREZINHA; BRUNALDI, MARIANGELA OTTOBONI; BUFALINO, ANDREIA; et al. Lipometaplasia in fibrous hyperplasia and inflammatory fibrous hyperplasia of the oral cavity. JOURNAL OF CUTANEOUS PATHOLOGY, v. N/A, p. 6-pg., . (16/11419-0, 22/12760-9)
SILVEIRA, HEITOR ALBERGONI; RAGUSA SILVA, PAULA VERONA; PIMENTEL, BRUNA GONCALVES; NOGUEIRA, GUSTAVO MILHOMENS; CHAHUD, FERNANDO; BRUNALDI, MARIANGELA OTTOBONI; LEON, JORGE ESQUICHE. Lymphomatoid Papulosis "Type E" Affecting the Palate: A Detailed Case Report and Review of Literature. AMERICAN JOURNAL OF DERMATOPATHOLOGY, v. 45, n. 5, p. 4-pg., . (18/12734-2, 16/11419-0, 22/12760-9)

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