Cancer Theranostics Innovation Center (CancerThera)

• Grant number: 21/10265-8
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• Start date: May 01, 2023
• End date: April 30, 2028
• Field of knowledge: Health Sciences - Medicine
• Principal Investigator: Carmino Antonio de Souza
• Grantee: Carmino Antonio de Souza
• Host Institution: Centro de Hematologia e Hemoterapia (HEMOCENTRO). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Pesquisadores principais: Carmen Silvia Passos Lima ; Celso Darío Ramos ; Elba Cristina Sá de Camargo Etchebehere ; José Barreto Campello Carvalheira ; Luciana Malavolta Quaglio ; Pedro Paulo Corbi ; Victor Marcelo Deflon
• Associated researchers: ALLAN DE OLIVEIRA SANTOS ; Ana Lúcia Tasca Gois Ruiz ; Andrea Paula Bruno Von Zuben ; Bárbara Juarez Amorim ; Bruno Kosa Lino Duarte ; Carlos Takahiro Chone ; Daniel Massaro Onusic ; Daniela Maira Cardozo ; Denise Engelbrecht Zantut Wittmann ; Edna Marina de Souza ; Fabiano Reis ; Fernando Rodrigues Goulart Bergamini ; Fernando Vieira Pericole de Souza ; Gilberto Carlos Franchi Junior ; Gislaine Oliveira Duarte ; Guilherme Brasil Duffles Amarante ; Guilherme Rossi Assis de Mendonça ; Gustavo Jacob Lourenço ; João Ernesto de Carvalho ; José Vassallo ; Jun Takahashi ; Katia Borgia Barbosa Pagnano ; Leonardo Lima Fuscaldi ; Ligia Traldi Macedo ; Ludmila Santiago Almeida ; Maria Carolina Santos Mendes ; Maria Cristina Cintra Gomes Marcondes ; Maria Emilia Seren Takahashi ; Mariana da Cunha Lopes de Lima ; Maurício Etchebehere ; Pedro Ivo da Silva Maia ; Samuel de Souza Medina ; Sergio Querino Brunetto ; Sergio San Juan Dertkigil ; Sibila Roberta Marques Grallert ; Thiago Ferreira de Souza ; Vânia Pereira de Castro Rodrigues
• Associated research grant(s): 24/07433-4 - Multi-user equipment (EMU) granted in process 2021/10265-8: SPECT/CT for dosimetry and theranostic applications, AP.EMU; 23/13788-7 - Multi-user equipment approved in grant 2021/10265-8: upgrade do PET/CT, AP.EMU; 23/13673-5 - Multi-user equipment approved in grant 2021/10265-8: nCounter® Pro analysis system, AP.EMU
• Associated scholarship(s): 25/01875-8 - Validation and supervision of in house synthesis methodology for the application of the radiopharmaceutical Pentixafor for theranostic of neoplasms, BP.PD; 25/00681-5 - Validation and supervision of in house synthesis methodology for the application of the radiopharmaceutical 68Ga-PSMA for theranostic of neoplasms., BP.DR; 24/11009-3 - Liver-to-brain ratio in the prognosis of patients with multiple myeloma, BP.IC; + associated scholarships 24/15854-0 - Validation and supervision of in house synthesis methodology for the application of the radiopharmaceutical FAPI for theranostic of neoplasms, BP.PD; 24/15448-1 - Assessment of the association of body composition and GDF-15 levels in patients with gastric and colorectal cancer., BP.MS; 24/15549-2 - Cell biology models for the evaluation of new metallo(radio)pharmaceuticals as diagnostic agents and potential chemotherapeutic drugs., BP.TT; 24/00467-0 - Scientific Dissemination of the Theranostic Approach to Cancer based on the Activities Developed by CEPID - CancerTher, BP.JC; 24/06333-6 - Evaluation of in vitro antiproliferative activity of AuDMAP complex on melanoma skin tumors, BP.IC; 24/00489-4 - Scientific Dissemination of the Theranostic Approach to Cancer based on the Activities Developed by CEPID - CancerThera, BP.JC; 24/05373-4 - Synthesis, characterization and purification of peptide complexes with the chelating agent DOTA for future radiolabeling processes with Ga-68., BP.IC; 24/03958-5 - Evaluation of the association of glucose uptake from visceral and subcutaneous adipose tissues and chemotherapy toxicity in patients with gastric and colorectal cancer., BP.IC; 24/01746-0 - Evaluation ofthe associationof bodycomposition,metabolism,systemicinflammation, andglucoseuptake,neoangiogenesis and fibroblastic remodeling ofthe extracellularmatrix ofvisceral andsubcutaneous adiposetissues in patients with gastricand colorectal cancer, BP.DR; 24/01501-8 - Cell lines for the evaluation of new metallo(radio)pharmaceuticals as potential diagnostic and therapeutic drugs., BP.TT; 23/12810-9 - Evaluation of radiolabeled anti-integrin peptide modified by conventional chelator as a theranostic agent in glioblastoma, BP.PD; 23/11857-1 - Metal complexes and nucleotide analogs: a proposal for the treatment of skin squamous cell carcinomas, BP.MS; 23/09854-4 - Evaluation of new silver complexes as innovative therapeutic strategies for treatment of Skin Squamous Cell Carcinoma, BP.DR - associated scholarships

Abstract

Cancer is a major public health problem worldwide and ranks among the leading causes of death. Identifying new agents for the diagnosis and treatment of patients with cancer is highly desirable. For many centuries, metals have been used empirically to treat various diseases. Nowadays, metals and their compounds - stable or radioactive - are rationally applied in both the diagnosis and treatment of neoplasms. A new type of cancer approach has gained worldwide prominence, the theranostic approach, a deriving term from "therapy" and "diagnosis". The overall theranostics concept involves identifying an active molecule related to a treatable target and subsequently radiolabeling the molecule for diagnosis (gamma or positron emitters) and therapeutic purposes (alpha or beta emitters). By reuniting researchers from a wide range of fields of expertise including such as Clinical Oncology, Onco-Hematology, Chemistry, Nuclear Medicine, Pharmacy, Statistics, Biology, and Physics, the effort aims to produce a Cancer Theranostics Innovation Center (CancerThera). CancerThera's goal is to develop an internationally competitive research center with qualified human resources for the creation and manipulation of pharmaceuticals and radiopharmaceuticals ((radio)pharmaceuticals) for the diagnosis and treatment of cancer in a theranostics approach. CancerThera will be divided into two interconnected teams - Basic Research and Clinical Research - which will develop converging projects. CancerThera Basic Research: Bioactive molecules will serve to synthesize new Metallo(radio)pharmaceuticals with potential action in diagnosis and blockage of tumor cell replications. Compounds and chelators will be conjugated with various tumor microenvironment-related peptides. The compounds will be radiolabeled with the pair gallium-68 and lutetium-177, which, respectively, allow the diagnosis and treatment of neoplasms, in addition to other radioisotopes. The biodistribution and/or antitumor action of the compounds will be evaluated in various preclinical studies. Investigations will include gamma counter analysis, micro-PET/SPECT/CT imaging, antiproliferative activity and cell death assays in tumor cell lines, and conventional evaluation. Further, inflammation/gene expression assays of toxicity and efficacy will be performed in animal tumor models. CancerThera Clinical Research: Possible new uses for already known molecules will be studied. The existing radiopharmacy at the host institution will be further set up and developed by the International Atomic Energy Agency project in force. The current radiopharmacy infrastructure will label various diagnostic oncology-based radioisotopes for possible cancer treatments. Investigations will be conducted on various cancer types (such as multiple myeloma, indolent lymphomas, colorectal and gastric cancers, glioblastoma multiforme, head, and neck cutaneous squamous cell carcinoma, Ph1-negative chronic myeloproliferative diseases, etc.). Genetic analysis of the radioactive-avid lesions will be performed. Continuous interaction between the CancerThera Basic and Clinical Research teams will take place in an unprecedented model in the country in this area. Thus, the radiopharmaceuticals successfully produced in Basic Research will be used in phase 1 and, eventually, phase 2 clinical studies. Likewise, new applications of known drugs will have their radiolabeling monitored by the Basic Research investigators. To ensure appropriation of the results of CancerThera by the society, different players from several institutions will be interconnected including investigators, scholars, research organizations, national and international funding agencies, micro-enterprises and large business corporations, governments (state and municipal), press, and ultimately the Brazilian society. (AU)

Scientific publications

(24)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DOUGLAS H. NAKAHATA; CARLOS E. S. P. CORSINO; GUILHERME C. DE MORAIS; GABRIELE M. PEREIRA; ÁLLEFE B. CRUZ; DOUGLAS HENRIQUE PEREIRA; NATASHA M. CASSANI; URIEL ENRIQUE A. RUIZ; IGOR A. SANTOS; ANA CAROLINA G. JARDIM; et al. Synthesis, Characterization and in vitro Evaluation of 4-(2-Aminoethyl)benzenesulfonamide Schiff Bases against Arboviruses. Journal of the Brazilian Chemical Society, v. 35, n. 11, 2024-05-10. (13/08293-7, 17/11485-6, 15/20882-3, 21/10265-8)

SILVA, LAURA BARROS; CRUZ, ALLEFE BARBOSA; PEREIRA, DOUGLAS HENRIQUE; CASSANI, NATASHA MARQUES; RUIZ, URIEL ENRIQUE AQUINO; SANTOS, IGOR ANDRADE; MARTINS, DANIEL OLIVEIRA SILVA; NAKAHATA, DOUGLAS HIDEKI; SIMONI, DEBORAH DE ALENCAR; KANAVOS, IOANNIS; et al. Antiviral Activity of Pd(II) Complexes with Aminoadamantanes Against Arboviruses. CHEMISTRYSELECT, v. 9, n. 37, p. 11-pg., 2024-10-01. (21/10265-8, 22/08320-3, 21/08717-8, 17/11485-6, 13/08293-7, 23/14245-7)

MARINHO, MIKAELA DOS SANTOS; ZHANG, YA-NAN; CASSANI, NATASHA MARQUES; SANTOS, IGOR ANDRADE; OLIVEIRA, ANA LAURA COSTA; PEREIRA, ANNA KARLA DOS SANTOS; CORBI, PEDRO PAULO; ZHANG, BO; JARDIM, ANA CAROLINA GOMES. Development and validation of Mayaro virus with luciferase reporter genes as a tool for antiviral assays. HELIYON, v. 10, n. 13, p. 11-pg., 2024-07-15. (18/12062-4, 21/10265-8)

NOGUEIRA-LIMA, ELLEN; ALVES, THIAGO; ETCHEBEHERE, ELBA. 18 F-Fluoride PET/CT-Updates. SEMINARS IN NUCLEAR MEDICINE, v. 54, n. 6, p. 15-pg., 2024-11-01. (21/10265-8)

ETCHEBEHERE, E.; SILVA, M.; TOBAR, N.; SANTOS, A. O.; BARBOSA, G. O.; LIMA, M. C. L.; CARVALHEIRA, J. B.; ETCHEBEHERE, M.. Comparison of PET/CT images with ¹⁸F-FDG and ¹⁸F-PSMA-1007 in musculoskeletal tumors to evaluate the potential of theranostics approach. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v. 51, p. 1-pg., 2024-09-01. (21/10265-8)

GENARO, LIVIA MOREIRA; CARRON, JULIANA; DE CASTRO, MARINA MOREIRA; FRANCESCHINI, ANA PAULA MENEZES DE FREITAS; LOURENCO, GUSTAVO JACOB; DA CRUZ, CRISTIANE KIBUNE NAGASAKO VIEIRA; REIS, GLAUCIA FERNANDA SOARES RUPERT; PASCOAL, LIVIA BITENCOURT; MELLO, JULIANA DELGADO CAMPOS; PEREIRA, ISABELA MACHADO; et al. Therapeutic drug monitoring and immunogenetic factors associated with the use of adalimumab in Crohn's disease patients. INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY, v. 39, p. 21-pg., 2025-01-01. (21/04349-4, 21/10265-8, 23/12810-9, 20/01924-5)

AMARAL, THAENY COSTA; SILVA, ADILSON D. DA; PEREIRA, GABRIELE DE M.; CORBI, PEDRO P.; CANALES, CHRISTIAN S. C.; PAVAN, FERNANDO R.; CUIN, ALEXANDRE. Synthesis, spectroscopic and structural characterizations and in vitro antimycobacterial activity of silver(I) complexes with sulfapyridine (SPY) and sulfamerazine (SM). Journal of Molecular Structure, v. 1300, p. 8-pg., 2023-12-12. (21/10265-8, 21/08717-8)

GONCALVES, ANA C. R.; LIBARDI, SILVIA H.; BORGES, JULIO C.; OLIVEIRA, RONALDO J.; GOTZMANN, CARLA; BLACQUE, OLIVIER; DE ALBUQUERQUE, SERGIO; LOPES, CARLA D.; ALBERTO, ROGER; MAIA, PEDRO I. S.. Rhenium(i) and technetium(i) complexes with megazol derivatives: towards the development of a theranostic platform for Chagas disease. DALTON TRANSACTIONS, v. N/A, p. 13-pg., 2024-11-06. (18/05576-1, 21/10265-8, 17/07335-9)

PEREIRA, GABRIELE DE MENEZES; NUNES, JULIA H. BORMIO; MACEDO, VINICIUS SOUZA; PEREIRA, DOUGLAS HENRIQUE; BUGLIO, KAIO EDUARDO; AFFONSO, DANIELE D.; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; FRAJACOMO, SILMARA CRISTINA L.; LUSTRI, WILTON R.; et al. Antibacterial profile and antiproliferative activities over human tumor cells of new silver(I) complexes containing two distinct trifluoromethyl uracil isomers. Journal of Inorganic Biochemistry, v. 262, p. 10-pg., 2024-10-04. (21/10265-8, 21/08717-8)

SILVA, AMANDA A.; FRAJACOMO, SILMARA C. L.; CRUZ, ALLEFE B.; BUGLIO, KAIO EDUARDO; AFFONSO, DANIELE DAIANE; PORTES, MARCELO CECCONI; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; LUSTRI, WILTON R.; PEREIRA, DOUGLAS H.; et al. Copper(II) and Platinum(II) Naproxenates: Insights on Synthesis, Characterization and Evaluation of Their Antiproliferative Activities. INORGANICS, v. 11, n. 8, p. 21-pg., 2023-08-01. (13/07937-8, 18/12062-4, 21/07458-9, 21/10265-8, 11/01114-4, 14/23950-7, 21/08717-8)

ETCHEBEHERE, E.; MENDANHA, D. M.; TOBAR, N.; MACEDO, L. T.; SANTOS, A. O.; LIMA, M. C. L.; LIMA, C. S. P.. Comparison of PET/CT images with ¹⁸F-FDG and ¹⁸F-PSMA-1007 in metastatic acral melanoma: a case report.. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v. 51, p. 2-pg., 2024-09-01. (21/10265-8)

PEREIRA, GABRIELE DE MENEZES; NUNES, JULIA HELENA BORMIO; FRAJACOMO, SILMARA CRISTINA LAZARINI; LUSTRI, WILTON ROGERIO; BERGAMINI, FERNANDO RODRIGUES GOULART; MOREIRA, JOSELIA CRISTINA DE OLIVEIRA; PONTES, ROBSON; RUIZ, ANA LUCIA T. G.; DE CARVALHO, JOAO ERNESTO; BARROS, WDESON PEREIRA; et al. Investigating the Antibacterial and Antitumoral Activities of New Copper(II) Complexes with Trifluoromethyluracil Isomers. CHEMISTRYSELECT, v. 10, n. 6, p. 8-pg., 2025-02-01. (21/10265-8)

LIMA, HELENA; ETCHEBEHERE, MARINA; BOGONI, MATEOS; TORRICELLI, CAROLINE; NOGUEIRA-LIMA, ELLEN; DEFLON, VICTOR M.; LIMA, MARIANA; ETCHEBEHERE, ELBA. Theranostics Nuclear Medicine in Prostate Cancer. PHARMACEUTICALS, v. 17, n. 11, p. 24-pg., 2024-11-01. (21/10265-8)

NAKAHATA, DOUGLAS H.; CORSINO, CARLOS E. S. P.; DE MORAIS, GUILHERME C.; PEREIRA, GABRIELE M.; CRUZ, ALLEFE B.; PEREIRA, DOUGLAS HENRIQUE; CASSANI, NATASHA M.; RUIZ, URIEL ENRIQUE A.; SANTOS, IGOR A.; JARDIM, ANA CAROLINA G.; et al. Synthesis, Characterization and in vitro Evaluation of 4-(2-Aminoethyl)benzenesulfonamide Schiff Bases against Arboviruses. Journal of the Brazilian Chemical Society, v. 35, n. 11, p. 12-pg., 2024-01-01. (21/10265-8, 13/08293-7, 15/20882-3, 17/11485-6)

REZENDE, WALLACE S.; NETO, ANTONIO MARCAL; CORBI, JULIANO J.; CORBI, PEDRO P.; DE PAIVA, RAPHAEL E. F.; BERGAMINI, FERNANDO R. G.. Coordination Compounds as Antivirals against Neglected Tropical Diseases. CHEMMEDCHEM, v. N/A, p. 18-pg., 2024-12-09. (21/10265-8, 20/09912-6)

MACHADO, RAIANE APARECIDA DOS SANTOS; SIQUEIRA, RAONI PAIS; DA SILVA, FERNANDA CARDOSO; DE MATOS, ANDRE CARLOS PEREIRA; BORGES, DAYANNE SILVA; ROCHA, GISLAINE GONCALVES; DE SOUZA, THAIS CRISTINA PRADO; SOUZA, RAFAEL APARECIDO CARVALHO; DE OLIVEIRA, CLAYTON RODRIGUES; FERREIRA, ANTONIO G.; et al. A New Heteroleptic Zn(II) Complex with Schiff Bases Sensitizes Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel. PHARMACEUTICS, v. 16, n. 12, p. 17-pg., 2024-12-01. (21/10265-8)

ETCHEBEHERE, E.; SOUSA, H. S. V.; TOBAR, N.; MACEDO, L. T.; KUBA, S.; SANTOS, A. O.; AMORIM, B. J.; LIMA, C. S. P.. Comparison of PET/CT images with ¹⁸F-FDG and ¹⁸F-PSMA-1007 in relapsed adenoid cystic carcinoma. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v. 51, p. 1-pg., 2024-09-01. (21/10265-8)

PADILHA, DANIELA M. H.; MENDES, MARIA C. S.; TAKAHASHI, MARIA E. S.; LASCALA, FABIANA; SILVEIRA, MARINA N.; POZZUTO, LARA; CARRILHO, LARISSA A. O.; GUERRA, LIVIA D.; MOREIRA, RAFAELLA C. L.; BRANBILLA, SANDRA R.; et al. Subcutaneous adipose tissue radiodensity: An emerging risk factor for severe COVID-19. NUTRITION, v. 128, p. 7-pg., 2024-09-14. (21/10265-8, 22/06239-4)

IGOR HENRIQUE CERQUEIRA; MARIA JULIA MIELI; ANNA KARLA DOS SANTOS PEREIRA; PEDRO PAULO CORBI; FLAVIA APARECIDA RESENDE. EVALUATION OF THE CYTOTOXICITY AND GENOTOXICOLOGICAL SAFETY PROFILE OF BIOACTIVE SILVER(I) COMPLEXES WITH AMINOADAMANTANE LIGANDS. Química Nova, v. 47, n. 6, 2024-03-11. (21/08717-8, 21/10265-8, 17/16278-9)

RODRIGUES TOLEDO, CIBELE; TANTAWY, AHMED A.; LIMA FUSCALDI, LEONARDO; MALAVOLTA, LUCIANA; DE AGUIAR FERREIRA, CAROLINA. EGFR- and Integrin α_Vβ₃-Targeting Peptides as Potential Radiometal-Labeled Radiopharmaceuticals for Cancer Theranostics. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 25, n. 15, p. 28-pg., 2024-08-01. (21/10265-8)

CANDIDO, TUANY ZAMBROTI; QUINTANILHA, MARIANA MAZZO; SCHIMITD, BIANCA ALVES; SIMONI, DEBORAH DE ALENCAR; NAKAHATA, DOUGLAS HIDEKI; DE PAIVA, RAPHAEL ENOQUE FERRAZ; CERQUEIRA, IGOR HENRIQUE; RESENDE, FLAVIA APARECIDA; CARVALHO, JOAO ERNESTO; RUIZ, ANA LUCIA TASCA GOIS; et al. Crystal Structure and Anti-Proliferative and Mutagenic Evaluation of the Palladium(II) Complex of Deoxyalliin. INORGANICS, v. 12, n. 7, p. 11-pg., 2024-07-01. (21/10265-8, 18/09860-6, 16/07729-4, 18/12062-4, 18/09856-9)

FERREIRA, HELEN SOARES VALENCA; RAMOS, LUANA MUNIQUE SOUSA; SILVA, FERNANDA CARDOSO; ALVES, DANIEL LIMA; PEREIRA, GABRIELE DE MENEZES; SANTIAGO, PEDRO HENRIQUE DE OLIVEIRA; DE ALMEIDA, ANGELINA MARIA; ELLENA, JAVIER; CORBI, PEDRO PAULO; OLIVEIRA, CAROLINA GONCALVES; et al. A new copper(II) complex containing long-chain aliphatic hydrazide and 1,10-phenanthroline upregulates ADP hydrolysis in triple-negative breast cancer cells. Journal of Inorganic Biochemistry, v. 255, p. 10-pg., 2024-03-19. (21/10265-8, 19/12219-3, 21/08717-8)

SILVA, AMANDA CRISTINA RIBEIRO; ANTUNES-CORREA, LIGIA DE MORAES; JULIANI, FABIANA LASCALA; CARRILHO, LARISSA ARIEL OLIVEIRA; OSO, FELIPE; MARTINEZ, CARLOS AUGUSTO REAL; MENDES, MARIA CAROLINA SANTOS; CARVALHEIRA, JOSE BARRETO CAMPELLO. Assessing the role of prognostic nutritional index in predicting outcomes for rectal cancer surgery. CLINICAL NUTRITION ESPEN, v. 63, p. 7-pg., 2024-08-07. (21/10265-8, 22/06239-4)

NUNES, JULIA HELENA BORMIO; NAKAHATA, DOUGLAS HIDEKI; CORBI, PEDRO PAULO; PAIVA, RAPHAEL ENOQUE FERRAZ DE. Beyond silver sulfadiazine: A dive into more than 50 years of research and development on metal complexes of sulfonamides in medicinal inorganic chemistry. Coordination Chemistry Reviews, v. 490, p. 45-pg., 2023-05-22. (21/10265-8, 21/08717-8)